Journal
NUTRIENTS
Volume 15, Issue 18, Pages -Publisher
MDPI
DOI: 10.3390/nu15183913
Keywords
glucagon; glucose; lipid; amino acid; hyperglucagonemia
Categories
Ask authors/readers for more resources
Glucagon has a broad role in metabolism, affecting glucose, amino acids, and lipid metabolism. Its secretion is regulated by nutrient intake, especially amino acids, and non-nutrient components. Recent research has shown the positive impact of glucagon agonists on lipid metabolism and energy homeostasis. The interaction between glucagon and other hormones, as well as the dysregulation of glucagon secretion in diseases like type 2 diabetes, is examined.
Glucagon was initially regarded as a hyperglycemic substance; however, recent research has revealed its broader role in metabolism, encompassing effects on glucose, amino acids (AAs), and lipid metabolism. Notably, the interplay of glucagon with nutrient intake, particularly of AAs, and non-nutrient components is central to its secretion. Fasting and postprandial hyperglucagonemia have long been linked to the development and progression of type 2 diabetes (T2DM). However, recent studies have brought to light the positive impact of glucagon agonists on lipid metabolism and energy homeostasis. This review explores the multifaceted actions of glucagon, focusing on its regulation, signaling pathways, and effects on glucose, AAs, and lipid metabolism. The interplay between glucagon and other hormones, including insulin and incretins, is examined to provide a mechanistic understanding of its functions. Notably, the liver-alpha-cell axis, which involves glucagon and amino acids, emerges as a critical aspect of metabolic regulation. The dysregulation of glucagon secretion and its impact on conditions such as T2DM are discussed. The review highlights the potential therapeutic applications of targeting the glucagon pathway in the treatment of metabolic disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available