Non-adherence to non-insulin glucose-lowering drugs: Prevalence, predictors and impact on glycemic control and insulin initiation. A longitudinal cohort study in a large primary care database in Spain

Article Endocrinology & Metabolism

9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes-2022

Summary: The American Diabetes Association's Standards of Medical Care in Diabetes provides clinical practice recommendations and tools to evaluate quality of care. It is updated regularly by a committee of experts.

DIABETES CARE (2022)

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Article Health Care Sciences & Services

Deprivation index by enumeration district in Spain, 2011

Ignacio Duque et al.

Summary: This study presented the methodology used in designing and implementing a deprivation index by enumeration district in Spain in 2011. Through analyzing census data, a deprivation index based on six indicators was constructed, showing a gradient of decreasing deprivation across Spain from southwest to northeast.

GACETA SANITARIA (2021)

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Review Endocrinology & Metabolism

Real-world adherence, persistence, and in-class switching during use of dipeptidyl peptidase-4 inhibitors: a systematic review and meta-analysis involving 594,138 patients with type 2 diabetes

Oyepeju Ogundipe et al.

Summary: Adherence to and persistence with DPP4 inhibitors among patients with type 2 diabetes mellitus is suboptimal but consistent across medications within the class. In-class switching is rare, with saxagliptin and alogliptin being the most commonly switched DPP4 inhibitors. Interventions to improve treatment adherence and persistence for this patient population may be needed.

ACTA DIABETOLOGICA (2021)

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Review Health Care Sciences & Services

An Adaptable Framework for Factors Contributing to Medication Adherence: Results from a Systematic Review of 102 Conceptual Frameworks

Kai Qi Elizabeth Peh et al.

Summary: This study identified and classified conceptual models for factors contributing to medication adherence based on the WHO's five dimensions, identified patient groups, and presented an adaptable conceptual model. The study highlighted the importance of patient-related factors and the varying representation of other factors across different patient groups. The conceptual models can be a useful guide for clinicians and researchers in developing interventions to improve medication adherence.

JOURNAL OF GENERAL INTERNAL MEDICINE (2021)

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Article Endocrinology & Metabolism

Adherence to antidiabetic treatment and impaired hypoglycemia awareness in type 2 diabetes mellitus assessed in Spanish community pharmacies: the ADHIFAC study

Fernando Gomez-Peralta et al.

Summary: The study conducted in community pharmacies in Spain assessed the prevalence of low adherence to antidiabetic treatments and impaired hypoglycemia awareness in patients with type 2 diabetes mellitus. Results showed that lack of adherence to antidiabetic treatments and impaired hypoglycemia awareness are common in patients with type 2 diabetes mellitus.

BMJ OPEN DIABETES RESEARCH & CARE (2021)

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Article Environmental Sciences

Factors Associated with Non-Adherence to Drugs in Patients with Chronic Diseases Who Go to Pharmacies in Spain

Carmen Valdes y Llorca et al.

Summary: The study findings revealed a high rate of non-adherence to pharmacological treatment among patients visiting pharmacies in Spain, with 48.4% found to be non-adherent. Factors such as difficulty in taking medication, self-medication, desire for more information, smoking, lower physical activity, younger age, and number of chronic treatments were significantly associated with non-adherence. The study highlights the concerning relationship between non-adherence, self-medication, and poor lifestyle choices in patients with multiple chronic diseases.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Pharmacology & Pharmacy

Alignment between outcomes and minimal clinically important differences in the Dutch type 2 diabetes mellitus guideline and healthcare professionals' preferences

Marloes Dankers et al.

Summary: Through an online questionnaire survey, healthcare professionals generally consider important outcomes in the treatment of type 2 diabetes including mortality, vascular diseases, and HbA1c, while weight and hypoglycemia are considered less important. They have stricter standards for the importance of HbA1c and hospital admissions, as well as the MCIDs for mortality and other hypoglycemia compared to the guideline committee.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2021)

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Article Endocrinology & Metabolism

Analysis of the Adherence and Safety of Second Oral Glucose-Lowering Therapy in Routine Practice From the Mediterranean Area: A Retrospective Cohort Study

Bogdan Vlacho et al.

Summary: The study aimed to compare adherence, time until discontinuation, and adverse events after adding DPP-4i, SGLT-2i, or SU to metformin in a primary care population. Results showed that the combination of SGLT-2i with metformin had better adherence and longer time until discontinuation compared to DPP-4i or SU groups.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Endocrinology & Metabolism