Volumetrically tracking retinal and choroidal structural changes in central serous chorioretinopathy

Central serous chorioretinopathy (CSCR) leads to the accumulation of subretinal fluid and retinal thickness change, which can be readily detected in clinics using optical coherence tomography (OCT). However, current quantification methods usually require sophisticated processing such as retinal layer segmentations, and volumetric visualization of structural changes is generally challenging, which can hinder fast and accurate assessment of disease progression and/or treatment efficacy. In this study, we developed an algorithm that can register the OCT scans acquired from different visits without requiring prior layer segmentation and calculated the three-dimensional (3-D) structural change maps for patients with CSCR. Our results demonstrate that this tool can be useful in monitoring the progression of CSCR and revealing the resolution of pathologies following treatment automatically with minimal pre-processing.(c) 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement

Automated summary

In this study, an algorithm was developed to register OCT scans of patients with CSCR without the need for prior layer segmentation, and to calculate three-dimensional structural change maps. This tool can aid in monitoring disease progression and treatment efficacy.