Heterogeneous receptor expression underlies non-uniform peptidergic modulation of olfaction in Drosophila

Sensory systems are dynamically adjusted according to the animal's ongoing needs by neuromodulators, such as neuropeptides. Neuropeptides are often widely-distributed throughout sensory networks, but it is unclear whether such neuropeptides uniformly modulate network activity. Here, we leverage the Drosophila antennal lobe (AL) to resolve whether myoinhibitory peptide (MIP) uniformly modulates AL processing. Despite being uniformly distributed across the AL, MIP decreases olfactory input to some glomeruli, while increasing olfactory input to other glomeruli. We reveal that a heterogeneous ensemble of local interneurons (LNs) are the sole source of AL MIP, and show that differential expression of the inhibitory MIP receptor across glomeruli allows MIP to act on distinct intraglomerular substrates. Our findings demonstrate how even a seemingly simple case of modulation can have complex consequences on network processing by acting non-uniformly within different components of the overall network.

Automated summary

Neuromodulators like neuropeptides dynamically adjust sensory systems in response to the animal's needs, but it is unclear whether their modulation is uniform in sensory networks. In a study using the fly olfactory system, researchers found that myoinhibitory peptide (MIP) decreases olfactory input to some regions while increasing it in others, revealing that MIP acts non-uniformly via differential expression of inhibitory MIP receptors in different regions.