Bi-enzymatic chemo-mechanical feedback loop for continuous self-sustained actuation of conducting polymers

Artificial actuators have been extensively studied due to their wide range of applications from soft robotics to biomedicine. Herein we introduce an autonomous bi-enzymatic system where reversible motion is triggered by the spontaneous oxidation and reduction of glucose and oxygen, respectively. This chemo-mechanical actuation is completely autonomous and does not require any external trigger to induce self-sustained motion. The device takes advantage of the asymmetric uptake and release of ions on the anisotropic surface of a conducting polymer strip, occurring during the operation of the enzymes glucose oxidase and bilirubin oxidase immobilized on its surface. Both enzymes are connected via a redox polymer at each extremity of the strip, but at the opposite faces of the polymer film. The time-asymmetric consumption of both fuels by the enzymatic reactions produces a double break of symmetry of the film, leading to autonomous actuation. An additional break of symmetry, introduced by the irreversible overoxidation of one extremity of the polymer film, leads to a crawling-type motion of the free-standing polymer film. These reactions occur in a virtually unlimited continuous loop, causing long-term autonomous actuation of the device.

Automated summary

This study introduces an autonomous bi-enzymatic system that utilizes the spontaneous oxidation and reduction of glucose and oxygen to trigger reversible motion. The system operates without the need for any external trigger, relying on the asymmetric uptake and release of ions on a conducting polymer strip that houses glucose oxidase and bilirubin oxidase enzymes. The time-asymmetric consumption of both fuels by the enzymatic reactions leads to the autonomous actuation of the device.