4.8 Article

Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Quantification of Antisense Oligonucleotides by Splint Ligation and Quantitative Polymerase Chain Reaction

Minwook Shin et al.

Summary: This study presents a method for detecting and quantifying various types of chemically modified ASOs in biological samples, without the need for probe modifications. The method is fast, sensitive, reliable, and can be widely applied for therapeutic oligonucleotide detection.

NUCLEIC ACID THERAPEUTICS (2022)

Article Biochemistry & Molecular Biology

DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)

Brad T. Sherman et al.

Summary: DAVID, a popular bioinformatics resource system, has undergone updates in 2021, including the rebuilding of the DAVID Gene system, increasing the number of gene-term records for annotation types, adding new annotations, assigning specific subgroups, and adding a species parameter for improved user experience.

NUCLEIC ACIDS RESEARCH (2022)

Article Medicine, Research & Experimental

MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling

Jiangbin Wu et al.

Summary: The study reveals that miR-574 plays a crucial role in cardiac diseases by regulating FAM210A expression and modulating mitochondrial-encoded protein expression, affecting cardiac remodeling.

EMBO MOLECULAR MEDICINE (2021)

Article Multidisciplinary Sciences

Disrupting upstream translation in mRNAs is associated with human disease

David S. M. Lee et al.

Summary: The study investigates genetic variants in upstream open reading frames, finding that they are under high evolutionary constraint and may contribute to disease.

NATURE COMMUNICATIONS (2021)

Article Medicine, Research & Experimental

DDX3X deficiency alleviates LPS-induced H9c2 cardiomyocytes pyroptosis by suppressing activation of NLRP3 inflammasome

Dandan Feng et al.

Summary: Increasing evidence suggests that DDX3X plays a vital role in the formation of the NLRP3 inflammasome and regulates cardiomyocyte injury induced by LPS. Knockdown of DDX3X significantly attenuates pyroptosis and cell damage in LPS-treated cardiomyocytes. Thus, DDX3X may serve as a potential therapeutic target for sepsis-induced cardiomyopathy.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Article Endocrinology & Metabolism

Knock-Out of DHTKD1( )Alters Mitochondrial Respiration and Function, and May Represent a Novel Pathway in Cardiometabolic Disease Risk

Chuan Wang et al.

Summary: This study identified the central role of the DHTKD1 gene in the 2-AAA pathway in Type 2 Diabetes and cardiometabolic disease. Knocking out this gene resulted in impaired mitochondrial structure and function, yet normal cell proliferation rate was maintained through compensatory mechanisms. These findings suggest DHTKD1-mediated mitochondrial dysfunction as a potential novel pathway in cardiometabolic disease.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Biochemistry & Molecular Biology

From embryogenesis to adulthood: Critical role for GATA factors in heart development and function

Jamieson Whitcomb et al.

IUBMB LIFE (2020)

Article Cardiac & Cardiovascular Systems

Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-Fibrotic Protein Synthesis During Cardiac Fibrosis

Jiangbin Wu et al.

CIRCULATION RESEARCH (2020)

Article Biochemistry & Molecular Biology

Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells

Jonathan Bohlen et al.

MOLECULAR CELL (2020)

Article Multidisciplinary Sciences

Structure of a human 48S translational initiation complex

Jailson Brito Querido et al.

SCIENCE (2020)

Article Cardiac & Cardiovascular Systems

Novel Therapies for Prevention and Early Treatment of Cardiomyopathies Now and in the Future

Giuliana G. Repetti et al.

CIRCULATION RESEARCH (2019)

Article Biochemistry & Molecular Biology

The Translational Landscape of the Human Heart

Sebastiaan van Heesch et al.

Article Biochemistry & Molecular Biology

DDX3X and specific initiation factors modulate FMR1 repeat-associated non-AUG-initiated translation

Alexander E. Linsalata et al.

EMBO REPORTS (2019)

Article Cardiac & Cardiovascular Systems

Monitoring Cell-Type-Specific Gene Expression Using Ribosome Profiling In Vivo During Cardiac Hemodynamic Stress

Shirin Doroudgar et al.

CIRCULATION RESEARCH (2019)

Article Multidisciplinary Sciences

mRNA structure regulates protein expression through changes in functional half-life

David M. Mauger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Genetics & Heredity

A helicase links upstream ORFs and RNA structure

Eckhard Jankowsky et al.

CURRENT GENETICS (2019)

Review Cell Biology

Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them

Kathrin Leppek et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4-NKX2-5 Interaction

Sini M. Kinnunen et al.

SCIENTIFIC REPORTS (2018)

Article Multidisciplinary Sciences

The helicase Ded1p controls use of near-cognate translation initiation codons in 5′ UTRs

Ulf-Peter Guenther et al.

NATURE (2018)

Review Cell Biology

Translation deregulation in human disease

Soroush Tahmasebi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression

Pauline Adjibade et al.

SCIENTIFIC REPORTS (2017)

Article Biotechnology & Applied Microbiology

Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames

Xue-hai Liang et al.

NATURE BIOTECHNOLOGY (2016)

Article Biochemistry & Molecular Biology

DHX29 reduces leaky scanning through an upstream AUG codon regardless of its nucleotide context

Vera P. Pisareva et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Peripheral Vascular Disease

Translational Control Mechanisms in Angiogenesis and Vascular Biology

Peng Yao et al.

CURRENT ATHEROSCLEROSIS REPORTS (2015)

Article Multidisciplinary Sciences

DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth

Sibylle Schleich et al.

NATURE (2014)

Review Biochemistry & Molecular Biology

A perspective on mammalian upstream open reading frame function

Joanna Somers et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

RNAstructure: web servers for RNA secondary structure prediction and analysis

Stanislav Bellaousov et al.

NUCLEIC ACIDS RESEARCH (2013)

Review Genetics & Heredity

Gene Expression Regulation by Upstream Open Reading Frames and Human Disease

Cristina Barbosa et al.

PLOS GENETICS (2013)

Article Multidisciplinary Sciences

Heart repair by reprogramming non-myocytes with cardiac transcription factors

Kunhua Song et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

Stringency of start codon selection modulates autoregulation of translation initiation factor eIF5

Gary Loughran et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Cardiac & Cardiovascular Systems

Mitochondrial Fusion is Essential for Organelle Function and Cardiac Homeostasis

Yun Chen et al.

CIRCULATION RESEARCH (2011)

Article Biochemical Research Methods

RNAstructure: software for RNA secondary structure prediction and analysis

Jessica S. Reuter et al.

BMC BIOINFORMATICS (2010)

Article Biochemical Research Methods

A structural interpretation of the effect of GC-content on efficiency of RNA interference

Chi Yu Chan et al.

BMC BIOINFORMATICS (2009)

Article Multidisciplinary Sciences

Accurate SHAPE-directed RNA structure determination

Katherine E. Deigan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

Sarah E. Calvo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemical Research Methods

Semiautomated and rapid quantification of nucleic acid footprinting and structure mapping experiments

Alain Laederach et al.

NATURE PROTOCOLS (2008)

Article Multidisciplinary Sciences

A threshold of GATA4 and GATA6 expression is required for cardiovascular development

Mei Xin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemical Research Methods

Tricine-SDS-PAGE

Hermann Schaegger

NATURE PROTOCOLS (2006)

Article Biotechnology & Applied Microbiology

Evolutionarily conserved non-AUG translation initiation in NAT1/p97/DAP5 (EIF4G2)

K Takahashi et al.

GENOMICS (2005)

Review Cardiac & Cardiovascular Systems

GATA transcription factors in the developing and adult heart

S Pikkarainen et al.

CARDIOVASCULAR RESEARCH (2004)

Article Cardiac & Cardiovascular Systems

Upregulation of embryonic transcription factors in right ventricular hypertrophy

H Bär et al.

BASIC RESEARCH IN CARDIOLOGY (2003)

Article Biochemistry & Molecular Biology

The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo

QR Liang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)