4.8 Article

Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice

Related references

Note: Only part of the references are listed.
Article Cell Biology

Report Synaptotagmin-1 is a Ca2+sensor for somatodendritic dopamine release

Joseph J. Lebowitz et al.

Summary: In this study, mouse genetics and whole-cell electrophysiology were used to demonstrate that the fast calcium sensor Synaptotagmin-1 (Syt-1) plays a crucial role in somatodendritic dopamine release. Ablation of Syt-1 from dopamine neurons significantly reduced stimulus-evoked D2 receptor-mediated inhibitory postsynaptic currents (D2-IPSCs), while D2-IPSCs evoked by paired stimuli exhibited less depression and high-frequency trains restored dopamine release.

CELL REPORTS (2023)

Article Neurosciences

Molecular and functional architecture of striatal dopamine release sites

Aditi Banerjee et al.

Summary: Efficient release site architecture mediated by RIM, Munc13, and Liprin-alpha is crucial for fast dopamine exocytosis.

NEURON (2022)

Article Neurosciences

Synaptotagmins 1 and 7 Play Complementary Roles in Somatodendritic Dopamine Release

Takuya Hikima et al.

Summary: This study reveals the critical role of high-affinity Ca2+ sensor synaptotagmin 7 (Syt7) in somatodendritic dopamine (DA) release. Both Syt7 and Syt1 are involved in the release of DA.

JOURNAL OF NEUROSCIENCE (2022)

Article Biochemistry & Molecular Biology

Implication of synaptotagmins 4 and 7 in activity-dependent somatodendritic dopamine release in the ventral midbrain

Benoit Delignat-Lavaud et al.

Summary: This study uncovers clear differences in the mechanisms of somatodendritic (STD) and axonal dopamine release. STD dopamine release has low capacity and differs from axonal release in terms of molecular mechanisms.

OPEN BIOLOGY (2022)

Review Neurosciences

Spatial and temporal scales of dopamine transmission

Changliang Liu et al.

Summary: Dopamine is a prototypical neuromodulator that controls circuit function through G protein-coupled receptor signaling. While dopamine is often described as a diffusive and slow signaling molecule, recent studies suggest that certain functions of dopamine require spatiotemporal precision.

NATURE REVIEWS NEUROSCIENCE (2021)

Article Cell Biology

Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron

Takuya Hikima et al.

Summary: Research suggests that somatodendritic dopamine release in the substantia nigra pars compacta autoinhibits the neuron that releases it.

CELL REPORTS (2021)

Article Biology

An open-source device for measuring food intake and operant behavior in rodent home-cages

Bridget A. Matikainen-Ankney et al.

Summary: Understanding both food intake and food motivation is crucial for uncovering mechanisms underlying feeding disorders. While operant behavioral testing can measure the motivational component of feeding, the FED3 provides a new solution for monitoring both food intake and motivation in rodent home-cages, allowing for longitudinal studies with minimal intervention. The open-source design files of FED3 also enable researchers to customize the device to fit their specific needs.

ELIFE (2021)

Article Biochemistry & Molecular Biology

Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals

Charles Ducrot et al.

Summary: The study found that dopamine neurons establish a distinctive axonal arbor in vitro, with differences in size and terminal propensity compared to glutamatergic or GABAergic neurons. While most dopamine varicosities are active, only about 20% of these are synaptic. Proteins neurexin-1 alpha and neuroligin-1 play a critical role in synapse formation by dopamine neurons.

FASEB JOURNAL (2021)

Review Neurosciences

Cell-based therapy for Parkinson's disease: A journey through decades toward the light side of the Force

Malin Parmar et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2019)

Article Multidisciplinary Sciences

Differential regulation of striatal motor behavior and related cellular responses by dopamine D2L and D2S isoforms

Daniela Radl et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites

Changliang Liu et al.

Article Multidisciplinary Sciences

Structural absorption by barbule microstructures of super black bird of paradise feathers

Dakota E. McCoy et al.

NATURE COMMUNICATIONS (2018)

Article Anatomy & Morphology

Evidence for Sprouting of Dopamine and Serotonin Axons in the Pallidum of Parkinsonian Monkeys

Dave Gagnon et al.

FRONTIERS IN NEUROANATOMY (2018)

Article Biochemistry & Molecular Biology

Immunochemical localization of vesicular monoamine transporter 2 (VMAT2) in mouse brain

Rachel A. Cliburn et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2017)

Article Neurosciences

Trafficking of Kv2.1 Channels to the Axon Initial Segment by a Novel Nonconventional Secretory Pathway

Camilla Stampe Jensen et al.

JOURNAL OF NEUROSCIENCE (2017)

Article Biochemistry & Molecular Biology

Enhanced Dopamine Release by Dopamine Transport Inhibitors Described by a Restricted Diffusion Model and Fast-Scan Cyclic Voltammetry

Alexander F. Hoffman et al.

ACS CHEMICAL NEUROSCIENCE (2016)

Article Neurosciences

Effect of Motor Impairment on Analgesic Efficacy of Dopamine D2/3 Receptors in a Rat Model of Neuropathy

Margarida Dourado et al.

JOURNAL OF EXPERIMENTAL NEUROSCIENCE (2016)

Review Neurosciences

Striatal dopamine neurotransmission: Regulation of release and uptake

David Sulzer et al.

BASAL GANGLIA (2016)

Review Biology

Somatodendritic dopamine release: recent mechanistic insights

Margaret E. Rice et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2015)

Review Neurosciences

Dopaminergic modulation of striatal networks in health and Parkinson's disease

D. James Surmeier et al.

CURRENT OPINION IN NEUROBIOLOGY (2014)

Article Neurosciences

In Vivo Amphetamine Action is Contingent on αCaMKII

Thomas Steinkellner et al.

NEUROPSYCHOPHARMACOLOGY (2014)

Article Multidisciplinary Sciences

Dopamine transporters govern diurnal variation in extracellular dopamine tone

Mark J. Ferris et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

Somatodendritic Dopamine Release Requires Synaptotagmin 4 and 7 and the Participation of Voltage-gated Calcium Channels

Jose Alfredo Mendez et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Multidisciplinary Sciences

Dendritic SNAREs add a new twist to the old neuron theory

Saak V. Ovsepian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Neurosciences

Control of Extracellular Dopamine at Dendrite and Axon Terminals

Christopher P. Ford et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Neurosciences

Impact of D2 Receptor Internalization on Binding Affinity of Neuroimaging Radiotracers

Ningning Guo et al.

NEUROPSYCHOPHARMACOLOGY (2010)

Article Behavioral Sciences

Tonic dopamine modulates exploitation of reward learning

Jeff A. Beeler et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2010)

Review Neurosciences

The dynamics of dopamine in control of motor behavior

Mati Joshua et al.

CURRENT OPINION IN NEUROBIOLOGY (2009)

Article Neurosciences

The Time Course of Dopamine Transmission in the Ventral Tegmental Area

Christopher P. Ford et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Multidisciplinary Sciences

Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior

Larry S. Zweifel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Behavioral Sciences

Food demand functions in mice

Melissa A. Chaney et al.

APPETITE (2008)

Article Multidisciplinary Sciences

Dopamine signaling in the dorsal striatum is essential for motivated behaviors - Lessons from dopamine-deficient mice

Richard D. Palmiter

MOLECULAR AND BIOPHYSICAL MECHANISMS OF AROUSAL, ALERTNESS, AND ATTENTION (2008)

Review Neurosciences

Glutamate in dopamine neurons:: Synaptic versus diffuse transmission

Laurent Descarries et al.

BRAIN RESEARCH REVIEWS (2008)

Article Multidisciplinary Sciences

Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis

Anton Maximov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Neurosciences

Presynaptic regulation of dendrodendritic dopamine transmission

Michael J. Beckstead et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2007)

Review Neurosciences

The debate over dopamine's role in reward: the case for incentive salience

Kent C. Berridge

PSYCHOPHARMACOLOGY (2007)

Article Neurosciences

Dopamine scales performance in the absence of new learning

Barbara Cagniard et al.

NEURON (2006)

Article Biochemistry & Molecular Biology

Basal somatodendritic dopamine release requires snare proteins

GD Fortin et al.

JOURNAL OF NEUROCHEMISTRY (2006)

Review Neurosciences

Mechanisms of neurotransmitter release by amphetamines: A review

D Sulzer et al.

PROGRESS IN NEUROBIOLOGY (2005)

Article Multidisciplinary Sciences

Dopamine transporters depolarize neurons by a channel mechanism

L Carvelli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Neurosciences

The synaptic vesicle cycle

TC Sudhof

ANNUAL REVIEW OF NEUROSCIENCE (2004)

Review Neurosciences

Presymptomatic compensation in Parkinson's disease is not dopamine-mediated

E Bezard et al.

TRENDS IN NEUROSCIENCES (2003)

Article Neurosciences

Effects of long-term treatment with dopamine receptor agonists and antagonists on terminal arbor size

CL Parish et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2002)

Article Neurosciences

Postnatal development of the dopaminergic system of the striatum in the rat

J Antonopoulos et al.

NEUROSCIENCE (2002)

Article Neurosciences

The role of dopamine receptors in regulating the size of axonal arbors

CL Parish et al.

JOURNAL OF NEUROSCIENCE (2001)