Journal
NATURE COMMUNICATIONS
Volume 14, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-023-40643-w
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The value of SARS-CoV-2 lateral flow immunoassay tests for estimating individual disease risk is unclear. The authors linked testing data from the REACT-2 study in England to hospital and death records and found that vaccinated individuals with a negative LFIA test were at a higher risk of hospitalisation and death.
The value of SARS-CoV-2 lateral flow immunoassay tests for estimating individual disease risk is unclear. Here, the authors link testing data from the REACT-2 study in England to hospital and death records and show that vaccinated individuals with a negative LFIA test were at a higher risk of hospitalisation and death. The value of SARS-CoV-2 lateral flow immunoassay (LFIA) tests for estimating individual disease risk is unclear. The REACT-2 study in England, UK, obtained self-administered SARS-CoV-2 LFIA test results from 361,801 adults in January-May 2021. Here, we link to routine data on subsequent hospitalisation (to September 2021), and death (to December 2021). Among those who had received one or more vaccines, a negative LFIA is associated with increased risk of hospitalisation with COVID-19 (HR: 2.73 [95% confidence interval: 1.15,6.48]), death (all-cause) (HR: 1.59, 95% CI:1.07, 2.37), and death with COVID-19 as underlying cause (20.6 [1.83,232]). For people designated at high risk from COVID-19, who had received one or more vaccines, there is an additional risk of all-cause mortality of 1.9 per 1000 for those testing antibody negative compared to positive. However, the LFIA does not provide substantial predictive information over and above that which is available from detailed sociodemographic and health-related variables. Nonetheless, this simple test provides a marker which could be a valuable addition to understanding population and individual-level risk.
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