Journal
EPIGENOMICS
Volume -, Issue -, Pages -Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2023-0214
Keywords
Barrett's esophagus; bisulfite pyrosequencing; DNA methylation; esophageal adenocarcinoma; long-segment Barrett's esophagus; magnifying narrow-band imaging; short-segment Barrett's esophagus
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This study examined the microarchitectures of non-neoplastic Barrett's esophagus (BE) associated with DNA methylation status using magnifying narrow-band imaging (NBI) endoscopy. The results showed that the magnifying NBI endoscopic features of non-neoplastic BE were correlated with DNA methylation as an independent factor. Conclusion: Microarchitectures of BE visualized by magnifying NBI endoscopy correlated with DNA methylation.
Aim: DNA methylation is involved in esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE). Microarchitectures of on-neoplastic BE associated with DNA methylation status were examined using magnifying narrow-band imaging (NBI) endoscopy. Patients and methods: Using biopsies from non-neoplastic BE without cancer (n = 66; N group), with EAC (n = 27; ADJ group) and EAC tissue (n = 22; T group), methylation of N33, DPYS, SLC16A12, miR124a3 and miR34bc genes were quantified. Magnifying NBI features of non-neoplastic BE were classified according to their morphologies. Results: The ADJ and T groups presented higher DNA methylation compared with the N group. Magnifying NBI endoscopic features of non-neoplastic BE also correlated with DNA methylation as an independent factor. Conclusion: Microarchitectures of BE visualized by magnifying NBI endoscopy correlated with DNA methylation.
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