☆ 4.5 Article

Tetraphenylethylene-Based Photoluminescent Self-Assembled Nanoparticles: Preparation and Biological Evaluation

ACS MEDICINAL CHEMISTRY LETTERS (2023)

Related references

Note: Only part of the references are listed.

Article Biochemistry & Molecular Biology

Cannabidiol as Self-Assembly Inducer for Anticancer Drug-Based Nanoparticles

Eleonora Colombo et al.

Summary: Cannabidiol (CBD), a compound found in Cannabis plants, is shown to be an effective inducer in the formation of nanoparticles. These nanoparticles, formed through solvent displacement, exhibit monodisperse and stable structures. They show low micromolar range cytotoxicity on human tumor cell lines, with the involvement of paclitaxel confirmed in the most effective nanoparticle (NP 8B) through further biological assays.

MOLECULES (2023)

Add to Collection

Review Biochemistry & Molecular Biology

Recent Advances in Aggregation-Induced Emission Active Materials for Sensing of Biologically Important Molecules and Drug Delivery System

Geeta A. Zalmi et al.

Summary: The emergence and development of aggregation induced emission (AIE) have attracted worldwide attention due to its unique photophysical phenomenon and for removing the obstacle of aggregation-caused quenching (ACQ). AIE has become an important aspect in various fields such as fluorescent material, sensing, bioimaging, optoelectronics, drug delivery system, and theranostics. This review focuses on AIE active materials and their applications, and also explores the potential of AIE active fluorescent material in supramolecular chemistry.

MOLECULES (2022)

Add to Collection

Article Pharmacology & Pharmacy

Squalene-Based Nano-Assemblies Improve the Pro-Autophagic Activity of Trehalose

Giulia Frapporti et al.

Summary: This study focuses on the rational design and synthesis of nano-lipid-trehalose conjugates for enhanced therapeutic application. The nanoassemblies, characterized by small diameter and high stability, exhibit improved pharmacokinetic profile.

PHARMACEUTICS (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Fatty Acids/Tetraphenylethylene Conjugates: Hybrid AIEgens for the Preparation of Peptide-Based Supramolecular Gels

Elisa Impresari et al.

Summary: Aggregation-induced emissive materials, composed of tetraphenylethylene scaffold combined with fatty acids of different lengths, have been synthesized and characterized for their ability to self-assemble into supramolecular emissive structures depending on chemical composition and water content. These compounds have also been utilized as N-terminus capping agents in peptide-based materials development, leading to the creation of luminescent fibrillary materials that are non-cytotoxic and capable of forming supramolecular gels in aqueous environments.

FRONTIERS IN CHEMISTRY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Folic acid functionalization for targeting self-assembled paclitaxel-based nanoparticles

Eleonora Colombo et al.

Summary: This study reports the self-assembly of hetero-nanoparticles composed of a conjugate with folic acid as the targeting agent and another conjugate with paclitaxel as the active agent. The hetero-nanoparticles with varying percentages of folic acid conjugates are characterized, and their biological activity is determined.

RSC ADVANCES (2022)

Add to Collection

Review Medicine, Research & Experimental

Recent Progress in Polymeric AIE-Active Drug Delivery Systems: Design and Application

Yang Pei et al.

Summary: Aggregation-induced emission (AIE) provides a new opportunity to overcome the drawbacks of traditional aggregation-induced quenching of chromophores, with applications spreading across various fields. In particular, the use of AIE-active fluorophores in drug delivery systems (DDSs) allows for imaging-guided therapy and pharmacodynamic monitoring, which has potential social importance. Polymeric AIE-active DDSs are gaining attention for their advantages in easy fabrication and tunable optical properties, and are promising for improving the effectiveness of cancer therapy, antibacterial treatment, and pharmacodynamic monitoring.

MOLECULAR PHARMACEUTICS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Self-Assembly Nanoparticles of Natural Bioactive Abietane Diterpenes

Epole Ntungwe et al.

Summary: Different approaches to enhance drug penetration through physiological barriers, such as self-assembly drug conjugates, have shown to be promising in improving drug activity and penetration, and reducing side effects. In this study, three molecules derived from natural products were synthesized as lead molecules for self-assembled nanoparticles, which demonstrated lower cytotoxicity compared to their individual form when tested on different cell lines. The nanoparticles showed potential as prodrugs for the release of cytotoxic lead molecules based on their size, zeta potential, and low release of drug at physiological pH.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Engineering, Biomedical

Aggregation-Induced Emission (AIE) Nanoparticles-Assisted NIR-II Fluorescence Imaging-Guided Diagnosis and Surgery for Inflammatory Bowel Disease (IBD)

Xiaoxiao Fan et al.

Summary: AIE NPs-assisted NIR-II fluorescence imaging is utilized for accurately tracing inflammatory lesions, monitoring inflammation severity, and detecting responses to drug interventions in IBD mouse models. This study highlights the great potential value of AIE NPs-assisted NIR-II fluorescence imaging for future diagnosis and imaging-guided surgery in IBD.

ADVANCED HEALTHCARE MATERIALS (2021)

Add to Collection

Article Chemistry, Medicinal

New Class of Betulinic Acid-Based Nanoassemblies of Cabazitaxel, Podophyllotoxin, and Thiocolchicine

Eleonora Colombo et al.

ACS MEDICINAL CHEMISTRY LETTERS (2020)

Add to Collection

Article Nanoscience & Nanotechnology

Programmed Self-Assembly of Protein-Coated AIE-Featured Nanoparticles with Dual Imaging and Targeted Therapy to Cancer Cells

Jie Li et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Add to Collection

Review Chemistry, Multidisciplinary

Progress, challenges, and future of nanomedicine

Chenyang Zhang et al.

NANO TODAY (2020)

Add to Collection

Article Pharmacology & Pharmacy

Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers

Eleonora Colombo et al.

PHARMACEUTICS (2019)

Add to Collection

Article Chemistry, Medicinal

Self-assembling Releasable Thiocolchicine Diphenylbutenylaniline Conjugates

Gaia Fumagalli et al.

ACS MEDICINAL CHEMISTRY LETTERS (2019)

Add to Collection

Article Chemistry, Medicinal

Heteronanoparticles by Self-Assembly of Ecdysteroid and Doxorubicin Conjugates To Overcome Cancer Resistance

Gaia Fumagalli et al.

ACS MEDICINAL CHEMISTRY LETTERS (2018)

Add to Collection

Review Chemistry, Multidisciplinary

Macrocycles and cages based on tetraphenylethylene with aggregation-induced emission effect

Hai-Tao Feng et al.

CHEMICAL SOCIETY REVIEWS (2018)

Add to Collection

Article Chemistry, Organic

Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks

Gaia Fumagalli et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Functionalized AIE nanoparticles with efficient deep-red emission, mitochondrial specificity, cancer cell selectivity and multiphoton susceptibility

Alexander Nicol et al.

CHEMICAL SCIENCE (2017)

Add to Collection

Article Chemistry, Medicinal

Heteronanoparticles by self-Assembly of Doxorubicin and Cyclopamine Conjugates

Gaia Fumagalli et al.

ACS MEDICINAL CHEMISTRY LETTERS (2017)

Add to Collection

Article Chemistry, Medicinal

4-(1,2-diarylbut-1-en-1-yl)isobutyranilide derivatives as inhibitors of topoisomerase II

Michael S. Christodoulou et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)

Add to Collection

Article Polymer Science

Light-responsive AIE nanoparticles with cytosolic drug release to overcome drug resistance in cancer cells

Youyong Yuan et al.

POLYMER CHEMISTRY (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Cyclopamine-Paclitaxel-Containing Nanoparticles: Internalization in Cells Detected by Confocal and Super-Resolution Microscopy

Gaia Fumagalli et al.

CHEMPLUSCHEM (2015)

Add to Collection

Article Chemistry, Multidisciplinary

Self-Assembled Squalene-based Fluorescent Heteronanoparticles

Stella Borrelli et al.

CHEMPLUSCHEM (2015)

Add to Collection

Article Chemistry, Medicinal

New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A

Stella Borrelli et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Synthesis and biological evaluation of novel tamoxifen analogues

Michael S. Christodoulou et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2013)

Add to Collection

Review Chemistry, Analytical

Fluorescent nanoparticles for intracellular sensing: A review

Maria J. Ruedas-Rama et al.

ANALYTICA CHIMICA ACTA (2012)

Add to Collection

Article Chemistry, Multidisciplinary

Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole

JD Luo et al.

CHEMICAL COMMUNICATIONS (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.