4.4 Review

Hantavirus infections in the South-Eastern European countries: A study of two cases and literature review

Journal

EXPERIMENTAL AND THERAPEUTIC MEDICINE
Volume 26, Issue 3, Pages -

Publisher

SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2023.12129

Keywords

Hantavirus; hemorrhagic fever; acute kidney injury; interstitial hemorrhage

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This study reported two cases of hemorrhagic fever with renal syndrome diagnosed in Romania, where the role of kidney needle biopsy in establishing the diagnosis was emphasized. The rarity of this infection in South-Eastern Europe and the difficulties encountered in diagnosing the disease were also highlighted. Furthermore, the key literature data on the epidemiology, pathogenesis, and management of this infection were reviewed.
Hantavirus infection is a rare zoonosis in South-Eastern Europe. Depending on the serotype involved, the virus can cause hemorrhagic fever with renal syndrome which is also known as endemic nephropathy, and cardiopulmonary syndrome. Prompt diagnosis of the disease is essential for reducing the risk of severe manifestations and complications like chronic kidney disease, secondary hypertension or even death because there is no specific treatment or vaccine approved. The present study reported two cases of hemorrhagic fever with renal syndrome diagnosed in the Department of Nephrology of The Fundeni Clinical Institute (Romania). In both patients, kidney needle biopsy played a major role in establishing the diagnosis. The difficulties encountered in diagnosing this disease were also emphasized, taking into consideration the rarity of this infection in South-Eastern Europe. The key literature data on the epidemiology, pathogenesis and management of this infection were further reviewed.

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