4.7 Article

SCF and IL-33 regulate mouse mast cell phenotypic and functional plasticity supporting a pro-inflammatory microenvironment

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Mast cells inhibit colorectal cancer development by inducing ER stress through secreting Cystatin C

Feifei Song et al.

Summary: This study reveals the anti-tumor function of mast cells (MCs) in colorectal cancer (CRC) progression and their ability to induce endoplasmic reticulum stress (ERS) in CRC cells. It highlights the potential of MC-targeted immunotherapy for CRC.

ONCOGENE (2023)

Review Cell Biology

The Controversial Role of Intestinal Mast Cells in Colon Cancer

Rosa Molfetta et al.

Summary: Mast cells are tissue-resident sentinels involved in various physiological and pathological processes. They are frequently observed in tumor microenvironments, but their role in tumor initiation and growth is still controversial.

CELLS (2023)

Review Cell Biology

Mast Cell-Tumor Interactions: Molecular Mechanisms of Recruitment, Intratumoral Communication and Potential Therapeutic Targets for Tumor Growth

Deisy Segura-Villalobos et al.

Summary: This article reviews the recent evidence regarding the complex relationship between mast cells (MCs) and tumor cells, discussing the multifaceted role of MCs in tumor growth, the signaling pathways that regulate MC function and migration inside tumors, the possible phenotypic changes of MCs triggered by prevalent conditions in the tumor microenvironment, and the potential role of MCs in tumor fibrosis and metastasis. The article also discusses novel literature on molecular mechanisms related to phenotypic changes of MCs in the tumor microenvironment and therapeutic strategies targeting MC activation to limit tumor growth.

CELLS (2022)

Review Allergy

KIT as a master regulator of the mast cell lineage

Mindy Tsai et al.

Summary: The discovery of the cell surface receptor KIT and its ligand, stem cell factor (SCF), in 1987/1988 and 1990 has greatly contributed to our understanding of the development and function of various cell lineages. Mutations in KIT or SCF can have significant effects on the development and/or function of hematopoietic progenitors, melanocytes, germ cells, and mast cells. The biological importance of KIT in other cell types is still not well understood.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Article Oncology

Mast cell-T cell axis alters development of colitis-dependent and colitis-independent colorectal tumours: potential for therapeutically targeting via mast cell inhibition

Juliana Y. Sakita et al.

Summary: This study investigated the activity of mast cells (MCs) throughout the development of colorectal cancer (CRC) and found that MCs have a dual role in CRC development. MC activity promotes engraftment of tumor cells while inhibiting the infiltration of CD8+ cells. These findings suggest the potential of MCs as druggable targets for the treatment of CRC.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

Article Allergy

Regulation of the pleiotropic effects of tissue-resident mast cells

Michael Huber et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Review Biochemistry & Molecular Biology

Future Needs in Mast Cell Biology

Gilda Varricchi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Immunology

Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family

Corinne Cayrol et al.

IMMUNOLOGICAL REVIEWS (2018)

Article Oncology

Tumor-infiltrating tryptase+ mast cells predict unfavorable clinical outcome in solid tumors

Guoming Hu et al.

INTERNATIONAL JOURNAL OF CANCER (2018)

Review Allergy

Mast cells signal their importance in health and disease

Ana Olivera et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner

Abdulrahman M. Saadalla et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Immunology

Mast cells, basophils and eosinophils: From allergy to cancer

A. Rigoni et al.

SEMINARS IN IMMUNOLOGY (2018)

Article Allergy

IL-33 fine tunes mast cell degranulation and chemokine production at the single-cell level

Regis Joulia et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Article Biochemical Research Methods

Chemically induced mouse models of acute and chronic intestinal inflammation

Stefan Wirtz et al.

NATURE PROTOCOLS (2017)

Review Immunology

Are Mast Cells MASTers in Cancer?

Gilda Varricchi et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Pharmacology & Pharmacy

IL-33 and Thymic Stromal Lymphopoietin in mast cell functions

Rohit Saluja et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

Review Immunology

Interleukin 33 is a guardian of barriers and a local alarmin

Nikolas T. Martin et al.

NATURE IMMUNOLOGY (2016)

Review Immunology

Interleukin-33 in health and disease

Foo Yew Liew et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Editorial Material Gastroenterology & Hepatology

c-Kit as a Novel Potential Therapeutic Target in Colorectal Cancer

Yatrik M. Shah et al.

GASTROENTEROLOGY (2015)

Article Biochemistry & Molecular Biology

Mast cells as targets for immunotherapy of solid tumors

Sharon A. Oldford et al.

MOLECULAR IMMUNOLOGY (2015)

Article Multidisciplinary Sciences

IL-33 activates tumor stroma to promote intestinal polyposis

Rebecca L. Maywald et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Biochemistry & Molecular Biology

IL-33/ST2 pathway contributes to metastasis of human colorectal

Xuejian Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

Murine Mast Cells Secrete and Respond to Interleukin-33

Hui-Ying Tung et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2014)

Article Multidisciplinary Sciences

IL-33/ST2 axis promotes mast cell survival via BCLXL

Jun-Xia Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Immunology

Mast cell secretory granules: armed for battle

Sara Wernersson et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Article Immunology

IL-33 Induces a Hyporesponsive Phenotype in Human and Mouse Mast Cells

Mi-Yeon Jung et al.

JOURNAL OF IMMUNOLOGY (2013)

Review Immunology

Protective and pathological roles of mast cells and basophils

David Voehringer

NATURE REVIEWS IMMUNOLOGY (2013)

Review Biochemistry & Molecular Biology

Role of mast cells in colorectal cancer development, the jury is still out

J. Heijmans et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

Review Immunology

Developmental Origin and Functional Specialization of Mast Cell Subsets

Michael F. Gurish et al.

IMMUNITY (2012)

Article Immunology

Stem Cell Factor Programs the Mast Cell Activation Phenotype

Tomonobu Ito et al.

JOURNAL OF IMMUNOLOGY (2012)

Review Biochemistry & Molecular Biology

IgE and mast cells in allergic disease

Stephen J. Galli et al.

NATURE MEDICINE (2012)

Article Immunology

Mast Cells as Sensors of Cell Injury through IL-33 Recognition

Mattias Enoksson et al.

JOURNAL OF IMMUNOLOGY (2011)

Article Multidisciplinary Sciences

Protease phenotype of constitutive connective tissue and of induced mucosal mast cells in mice is regulated by the tissue

Wei Xing et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Oncology

Prevention of Colitis-Associated Carcinogenesis with Infliximab

Yoon Jae Kim et al.

CANCER PREVENTION RESEARCH (2010)

Article Biochemistry & Molecular Biology

Synovial Fibroblasts Promote the Expression and Granule Accumulation of Tryptase via Interleukin-33 and Its Receptor ST-2 (IL1RL1)

Shinjiro Kaieda et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Review Hematology

Mast cells and mastocytosis

Dean D. Metcalfe

BLOOD (2008)

Article Oncology

A protective role of mast cells in intestinal tumorigenesis

Mark J. Sinnamon et al.

CARCINOGENESIS (2008)

Article Multidisciplinary Sciences

Mast cells are an essential hematopoietic component for polyp development

Elias Gounaris et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Cell Biology

IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcεRI signals

Lien H. Ho et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2007)

Review Immunology

Development migration, and survival of mast cells

Yoshimichi Okayama et al.

IMMUNOLOGIC RESEARCH (2006)

Article Gastroenterology & Hepatology

Prognostic significance of cell infiltrations of immunosurveillance in colorectal cancer

Shi-Yun Tan et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2005)

Review Immunology

Regulation of mast-cell and basophil function and survival by IgE

T Kawakami et al.

NATURE REVIEWS IMMUNOLOGY (2002)