☆ 4.7 Article

UHRF1 inhibition epigenetically reprograms cancer stem cells to suppress the tumorigenic phenotype of hepatocellular carcinoma

CELL DEATH & DISEASE (2023)

Related references

Note: Only part of the references are listed.

Article Pharmacology & Pharmacy

Lenvatinib inhibited HCC cell migration and invasion through regulating the transcription and ubiquitination of UHRF1 and DNMT1

Ting Fang et al.

Summary: In this study, it was found that Lenvatinib can inhibit the metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma cells. This effect is achieved by negatively regulating the transcription of UHRF1 and DNMT1 through the ERK/MAPK pathway, as well as promoting their protein degradation through the ubiquitin-proteasome pathway. Consequently, the expression of E-Cadherin is upregulated and the adhesion and metastasis of Huh7 cells are attenuated in vivo.

BIOCHEMICAL PHARMACOLOGY (2023)

Add to Collection

Article Cell Biology

UHRF1 establishes crosstalk between somatic and germ cells in male reproduction

Yanqing Wu et al.

Summary: This study reveals the importance of UHRF1 in the epigenetic regulation of Sertoli cells during spermatogenesis. UHRF1 regulates the expression of extracellular matrix-related genes and establishes the crosstalk between Sertoli cells and germ cells.

CELL DEATH & DISEASE (2022)

Add to Collection

Review Cell Biology

Mechanism of cancer stemness maintenance in human liver cancer

Ning Liang et al.

Summary: Primary liver cancer consists of hepatocellular carcinoma, cholangiocarcinoma, hepatoblastoma, and combined hepatocellular carcinoma and cholangiocarcinoma. Recent studies have found differences in cancer stem cell properties among different liver cancer types. Liver cancer stem cells, also known as liver tumor-initiating cells, are considered to be drivers of tumor initiation and metastasis, and are regulated by various mechanisms and factors. This review presents an analysis of cancer stemness in different liver cancer types, evaluates the mechanisms of cancer stemness maintenance in liver cancer stem cells, and discusses potential treatments for eradicating liver cancer stem cells.

CELL DEATH & DISEASE (2022)

Add to Collection

Article Oncology

A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog-Dependent Tumor Growth

Fan Yang et al.

Summary: Dysregulation of SHH signaling contributes to the growth of cancer subtypes, and resistance to current SHH inhibitors is a common issue. A novel UHRF1/DNMT1/GLI complex has been identified as a potential target for regulating SHH-dependent tumor growth, with an FDA-approved drug capable of disrupting this complex to attenuate tumor growth.

MOLECULAR CANCER RESEARCH (2022)

Add to Collection

Article Cell Biology

Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia

Cheng-Long Hu et al.

Summary: Aberrant expression of UHRF1, an epigenetic regulator, in acute myeloid leukemia (AML) is associated with poor prognosis. UHRF1 is crucial for the self-renewal of leukemia initiation cells (LICs) and its interaction with SAP30 represses gene expression. Inhibition of UHRF1 or SAP30 leads to derepression of MXD4, an MYC antagonist, and suppresses leukemogenesis. Furthermore, a UHRF1 inhibitor, UF146, shows promising therapeutic efficacy in a myeloid leukemia model.

CELL RESEARCH (2022)

Add to Collection

Article Biochemistry & Molecular Biology

PGC7 promotes tumor oncogenic dedifferentiation through remodeling DNA methylation pattern for key developmental transcription factors

Qian Yan et al.

Summary: In poorly differentiated hepatocellular carcinoma (HCC), the maternal factor PGC7 is found to be closely associated with liver development and tumor differentiation. PGC7 plays a role in inducing promoter demethylation of genes related to development, leading to downstream effects on key developmental transcription factors. Inhibition of PGC7/GLI1/MYCN might reverse poorly differentiated HCCs and provide new therapeutic strategies.

CELL DEATH AND DIFFERENTIATION (2021)

Add to Collection

Article Gastroenterology & Hepatology

DNA Methylation Profiling of Human Hepatocarcinogenesis

Gabriela Hernandez-Meza et al.

Summary: This study identified DNA methylation changes during the transition from preneoplastic lesions to early HCC and potential epigenetic gatekeepers. Additionally, methylation changes in cirrhotic tissue were found to correlate with clinical outcomes.

HEPATOLOGY (2021)

Add to Collection

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Add to Collection

Article Immunology

uhrf1 and dnmt1 Loss Induces an Immune Response in Zebrafish Livers Due to Viral Mimicry by Transposable Elements

Elena Magnani et al.

Summary: The activation of transposable elements (TEs) can lead to cellular damage, where cytoplasmic nucleic acid sensing pathways play a role in not only detecting pathogens but also eliminating cells with inappropriate TE activation. DNA methylation plays a direct role in suppressing certain subclasses of TEs, while the induction of interferon response and tnfa activation in liver cells of mutant organisms mimics gene expression patterns seen in virally infected cells. Antiviral response induced by DNA hypomethylation and TE activation in the liver is mediated by signaling pathways activated by both cytoplasmic double stranded RNA and DNA, with tnfa potentially mediating cell death as a mechanism to eliminate damaged cells.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Gastroenterology & Hepatology

Cancer stem cells in hepatocellular carcinoma - from origin to clinical implications

Terence Kin-Wah Lee et al.

Summary: Hepatocellular carcinoma (HCC) is an aggressive disease with poor prognosis, powered by a subset of cancer stem cells (CSCs). Research on liver CSCs has revealed their heterogeneity and unique immunobiology, suggesting potential for new research directions and therapies for HCC.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets

Ming Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Targeted therapy for hepatocellular carcinoma

Ao Huang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Add to Collection

Article Cell & Tissue Engineering

Plasticity of Cancer Stem Cell: Origin and Role in Disease Progression and Therapy Resistance

Plabon Kumar Das et al.

STEM CELL REVIEWS AND REPORTS (2020)

Add to Collection

Article Cell Biology

Epigenetic Compensation Promotes Liver Regeneration

Shuang Wang et al.

DEVELOPMENTAL CELL (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Guide Positioning Sequencing identifies aberrant DNA methylation patterns that alter cell identity and tumor-immune surveillance networks

Jin Li et al.

GENOME RESEARCH (2019)

Add to Collection

Review Gastroenterology & Hepatology

Wnt-β-catenin signalling in liver development, health and disease

Maria J. Perugorria et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Add to Collection

Article Cell Biology

FOXM1 contributes to taxane resistance by regulating UHRF1-controlled cancer cell stemness

Bowen Yuan et al.

CELL DEATH & DISEASE (2018)

Add to Collection

Article Multidisciplinary Sciences

Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a

Kun-Yong Kim et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Article Oncology

Overexpression of UHRF1 promotes silencing of tumor suppressor genes and predicts outcome in hepatoblastoma

Alexander Beck et al.

CLINICAL EPIGENETICS (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Role of canonical Hedgehog signaling pathway in liver

Lili Gao et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Add to Collection

Article Multidisciplinary Sciences

Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes

Jingyao Zhao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Add to Collection

Review Biotechnology & Applied Microbiology

Marked for death: targeting epigenetic changes in cancer

Sophia Xiao Pfister et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Add to Collection

Review Oncology

The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer

Waseem Ashraf et al.

ONCOTARGET (2017)

Add to Collection

Article Cell Biology

UHRF1 is required for basal stem cell proliferation in response to airway injury

Handan Xiang et al.

CELL DISCOVERY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma

Adrian Ally et al.

CELL (2017)

Add to Collection

Article Cell Biology

Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells

Jung Seon Seo et al.

BMC CELL BIOLOGY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Resetting cancer stem cell regulatory nodes upon MYC inhibition

Silvia Galardi et al.

EMBO REPORTS (2016)

Add to Collection

Article Gastroenterology & Hepatology

DNMT1 Is a Required Genomic Regulator for Murine Liver Histogenesis and Regeneration

Kosuke Kaji et al.

HEPATOLOGY (2016)

Add to Collection

Article Oncology

Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non-Small Cell Lung Cancer

Namrata Bora-Singhal et al.

NEOPLASIA (2015)

Add to Collection

Review Gastroenterology & Hepatology

Emerging Roles of Notch Signaling in Liver Disease

Fabian Geisler et al.

HEPATOLOGY (2015)

Add to Collection

Article Oncology

Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer

Xiaojing Yang et al.

CANCER CELL (2014)

Add to Collection

Article Oncology

UHRF1 Overexpression Drives DNA Hypomethylation and Hepatocellular Carcinoma

Raksha Mudbhary et al.

CANCER CELL (2014)

Add to Collection

Article Oncology

Epigenetic Targeting of Ovarian Cancer Stem Cells

Yinu Wang et al.

CANCER RESEARCH (2014)

Add to Collection

Article Gastroenterology & Hepatology

Epigenetic Reprogramming Modulates Malignant Properties of Human Liver Cancer

Chiara Raggi et al.

HEPATOLOGY (2014)

Add to Collection

Article Gastroenterology & Hepatology

Cellular reprogramming and hepatocellular carcinoma development

Yun-Wen Zheng et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2013)

Add to Collection

Review Genetics & Heredity

Functions of DNA methylation: islands, start sites, gene bodies and beyond

Peter A. Jones

NATURE REVIEWS GENETICS (2012)

Add to Collection

Article Gastroenterology & Hepatology

EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features

Taro Yamashita et al.

GASTROENTEROLOGY (2009)

Add to Collection

Article Multidisciplinary Sciences

The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

Jafar Sharif et al.

NATURE (2007)

Add to Collection

Article Multidisciplinary Sciences

Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression

DR Rhodes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Add to Collection

Article Oncology

Prognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma -: A broad survey using high-throughput tissue microarray

Y Wang et al.

CANCER (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.