Hypoglycemic effect of polysaccharides of Dendrobium officinale compound on type 2 diabetic mice

This study investigated the hypoglycemic effect of polysaccharides of Dendrobium officinale compound (DOCP) on streptozotocin induced type 2 diabetic mice. Compared with the model group, the fasting blood glucose value of DOCP (800 mg/kg) at day 35 of the study significantly decreased (P < 0.05). Meanwhile, DOCP (800 mg/kg) significantly increased the serum insulin content and reduced the insulin resistance in type 2 diabetic mice. Furthermore, DOCP reduced the serum total cholesterol, triglyceride and LDL-C concentrations, increased the antioxidant capability, and improved liver and pancreas damage in type 2 diabetic mice. DOCP increased the diversity of intestinal flora composition, and the abundance of beneficial bacteria such as Lactobacillus and Bifidobacteriaceae. DOCP (800 mg/kg) induced up-regulation expression of genes such as Glut2, Gck, Pklr, Insr, Pdx-1 and Ins1, but elicited down-regulation of Caspase-3. These results indicate that DOCP achieves antidiabetic and hypolipidemic effects in type 2 diabetic mice.

Automated summary

This study investigated the hypoglycemic and hypolipidemic effects of polysaccharides of Dendrobium officinale compound (DOCP) on streptozotocin induced type 2 diabetic mice. DOCP significantly decreased fasting blood glucose and insulin resistance, increased serum insulin content, reduced lipid levels, improved antioxidant capability, and protected liver and pancreas. DOCP also increased the diversity of intestinal flora and up-regulated the expression of key genes related to glucose metabolism.