Journal
MUSCLE & NERVE
Volume 55, Issue 2, Pages 232-242Publisher
WILEY
DOI: 10.1002/mus.25211
Keywords
hemisection; mice; muscle atrophy; muscle fiber type; spinal cord injury; treadmill
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Funding
- National Health and Medical Research Council [628765]
- Melbourne International Research Scholarship from the University of Melbourne
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Introduction: Treadmill training is known to prevent muscle atrophy after spinal cord injury (SCI), but the training duration required to optimize recovery has not been investigated. Methods: Hemisected mice were randomized to 3, 6, or 9 weeks of training or no training. Muscle fiber type composition and fiber cross-sectional area (CSA) of medial gastrocnemius (MG), soleus (SOL), and tibialis anterior (TA) were assessed using ATPase histochemistry. Results: Muscle fiber type composition of SCI animals did not change with training. However, 9 weeks of training increased the CSA of type IIB and IIX fibers in TA and MG muscles. Conclusions: Nine weeks of training after incomplete SCI was effective in preventing atrophy of fast-twitch muscles, but there were limited effects on slow-twitch muscles and muscle fiber type composition. These data provide important evidence of the benefits of exercising paralyzed limbs after SCI. Muscle Nerve, 2016 Muscle Nerve55: 232-242, 2017
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