Targeted approaches to delineate neuronal morphology during early development

Understanding the developmental changes that affect neurons is a key step in exploring the assembly and maturation of neural circuits in the brain. For decades, researchers have used a number of labeling techniques to visualize neuronal morphology at different stages of development. However, the efficiency and accuracy of neuronal labeling technologies are limited by the complexity and fragility of neonatal brains. In this review, we illustrate the various labeling techniques utilized for examining the neurogenesis and morphological changes occurring during the early stages of development. We compare the advantages and limitations of each technique from different aspects. Then, we highlight the gaps remaining in our understanding of the structure of neurons in the neonatal mouse brain.

Automated summary

Understanding developmental changes in neurons is crucial for exploring the assembly and maturation of neural circuits in the brain. This review discusses various labeling techniques used to study neurogenesis and morphological changes during early development. The advantages, limitations, and remaining gaps in understanding the structure of neurons in the neonatal mouse brain are highlighted.