☆ 4.6 Article

Quercetin and its derivatives for wound healing in rats/mice: Evidence from animal studies and insight into molecular mechanisms

INTERNATIONAL WOUND JOURNAL (2023)

Related references

Note: Only part of the references are listed.

Article Dermatology

The burden of skin diseases in India: Global Burden of Disease Study 2017

Kavita Kavita et al.

Summary: This report examines the burden of skin and subcutaneous diseases in India in terms of years lived with disability and age-standardized years lived with disability using the Global Burden of Disease Study results from 2017. Results show that in 2017, skin and subcutaneous diseases accounted for 4.02% of the total years lived with disability in India. There was a 53.7% increase in age-standardized years lived with disability for all skin and subcutaneous diseases from 1990 to 2017.

INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY (2023)

Add to Collection

Article Endocrinology & Metabolism

Melatonin inhibits atherosclerosis progression via galectin-3 downregulation to enhance autophagy and inhibit inflammation

Zitong Wang et al.

Summary: In this study, it was found that melatonin (Mel) inhibits atherosclerosis (AS) progression by downregulating Galectin-3 (Gal-3) to enhance autophagy and inhibit inflammation. Mel treatment showed promising potential as a treatment for AS.

JOURNAL OF PINEAL RESEARCH (2023)

Add to Collection

Article Immunology

Sustained activation of NLRP3 inflammasome contributes to delayed wound healing in aged mice

Haiyun Li et al.

Summary: Cutaneous wounds in the elderly heal poorly due to persistent inflammation and insufficient ECM deposition. The NLRP3 inflammasome plays a critical role in age-related inflammatory diseases and impaired wound healing. In this study, the activation of NLRP3 inflammasome was found to be increased in aged mice, causing a delay in wound healing. The application of NLRP3 inhibitor (MCC950) improved wound healing in aged mice by reducing inflammation and cell death.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

Add to Collection

Article Endocrinology & Metabolism

BPS-induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT-1/Nrf2/NF?B and IR/PI3K/pAkt/GLUT-4 expressions in adult golden hamster

Sriparna Pal et al.

Summary: The increasing number of plastic-manufacturing industries is causing environmental pollution and negatively impacting human and reproductive health. Bisphenol S (BPS), previously believed to be a safer alternative to bisphenol A (BPA), has been found to have toxic effects on the nervous system, liver, kidneys, and reproduction. The study demonstrates that melatonin can protect ovarian function from the detrimental effects of BPS, highlighting its potential as a preemptive treatment for environmental toxins and compromised female reproductive health.

JOURNAL OF PINEAL RESEARCH (2023)

Add to Collection

Article Endocrinology & Metabolism

Melatonin improves skin barrier damage caused by sleep restriction through gut microbiota

Weitian Li et al.

Summary: It is necessary to explore the relationship between sleep deprivation and skin damage and find effective treatments. Our research showed that lack of sleep impairs skin barrier function, disrupts biological clock oscillations, and affects the circadian rhythm of Bacteroides. Oral melatonin supplementation improves skin damage by restoring the circadian rhythm of Bacteroides and its propionic acid metabolite. Propionic acid produced by gut microbiota plays a role in improving skin barrier function.

JOURNAL OF PINEAL RESEARCH (2023)

Add to Collection

Article Medicine, Research & Experimental

Wound healing potential of quercetin-3-O-rhamnoside and myricetin-3-O-rhamnoside isolated from Pistacia lentiscus distilled leaves in rats model

Wiem Elloumi et al.

Summary: The study demonstrated that Pistacia lentiscus distilled leaves extract and its two isolated glycosylated flavonoids have the potential to accelerate wound healing, reduce inflammation, and enhance collagen biosynthesis in wound tissues.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Acceleration of wound healing by quercetin in diabetic rats requires mitigation of oxidative stress and stimulation of the proliferative phase

Vinay Kant et al.

Summary: Increased oxidative stress in diabetic wound areas impairs wound healing. Quercetin, with its significant antioxidant properties, was found to improve antioxidant status in wounds of diabetic rats and stimulate the proliferation phase, thereby accelerating wound healing.

BIOTECHNIC & HISTOCHEMISTRY (2022)

Add to Collection

Article Dermatology

Temporal Effects of Different Vehicles on Wound Healing Potentials of Quercetin: Biochemical, Molecular, and Histopathological Approaches

Vinay Kant et al.

Summary: This study explored the wound healing potential of 0.3% quercetin formulated in three different vehicles in rats. The results show that 0.3% quercetin mixed in ointment base produced the fastest and better wound healing, with increased blood vessel formation, collagen deposition, and regenerated epithelial layer. Quercetin treatment also improved antioxidant enzyme activity and reduced oxidative damage markers in the wound tissues.

INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Effects of Quercetin and Curcumin Combination on Antibacterial, Antioxidant, In Vitro Wound Healing and Migration of Human Dermal Fibroblast Cells

Chuda Chittasupho et al.

Summary: This study evaluates the effect of different ratios of quercetin and curcuminoids on antimicrobial, antioxidant, cell migration, and wound healing properties. The results demonstrate that the combination of quercetin and curcuminoids inhibits the growth of S. aureus and P. aeruginosa, has lower antioxidant activity compared to curcuminoids alone, and promotes fibroblast migration and wound closure.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Dermatology

Rational selection of bioactive principles for wound healing applications: Growth factors and antioxidants

Pamela Viana-Mendieta et al.

Summary: Wound healing is a complex process involving communication between growth factors and antioxidants, which play important roles in treating non-healing cutaneous conditions. The simultaneous use of growth factors and antioxidants may have an additive or synergistic effect, potentially improving wound healing outcomes.

INTERNATIONAL WOUND JOURNAL (2022)

Add to Collection

Article Plant Sciences

Quercetin promotes cutaneous wound healing in mice through Wnt/β-catenin signaling pathway

Yuhui Mi et al.

Summary: The study aimed to evaluate the healing effect of quercetin on cutaneous wound models in vivo and in vitro, and to reveal the mechanisms involved, including the Wnt/beta-catenin pathway and TERT.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Add to Collection

Article Endocrinology & Metabolism

Melatonin modulates Nrf2 activity to protect porcine pre-pubertal Sertoli cells from the abnormal H2O2 generation and reductive stress effects of cadmium

Desiree Bartolini et al.

Summary: Melatonin (MLT) has a cytoprotective effect on porcine pre-pubertal Sertoli cells (SCs) against cadmium (Cd) toxicity, reducing oxidative stress and reductive stress by regulating Nrf2 activity.

JOURNAL OF PINEAL RESEARCH (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Health Benefits of Quercetin in Age-Related Diseases

Deepika et al.

Summary: Polyphenols, including the widely occurring quercetin, are a group of plant compounds with antioxidant properties that protect against aging and various age-related diseases. Quercetin, present in abundant quantities in nature and particularly in onions, possesses antioxidant, anti-inflammatory, anti-carcinogenic, and anti-diabetic properties. It can easily cross the blood-brain barrier and has shown potential as a curative agent in neurodegeneration, diabetes, cancer, and inflammation. Further studies and formulations of quercetin could explore its potential in treating other age-associated diseases.

MOLECULES (2022)

Add to Collection

Review Cell & Tissue Engineering

Wound healing, fibroblast heterogeneity, and fibrosis

Heather E. Talbott et al.

Summary: Fibroblasts are important cells in tissue repair and fibrosis, but our understanding of the mechanisms by which they contribute to extracellular matrix deposition and remodeling is limited. This review discusses the current state of fibroblast biology and heterogeneity, with a focus on their role in skin wound repair, and evaluates the limitations of existing techniques and knowledge. The review highlights the critical functions of fibroblasts, a often overlooked cell type, in wound repair and other processes.

CELL STEM CELL (2022)

Add to Collection

Review Biotechnology & Applied Microbiology

Macrophages as a therapeutic target to promote diabetic wound healing

Maryam Sharifiaghdam et al.

Summary: This review examines the role of macrophages in the wound healing process and the aberrations that occur in macrophages under diabetic conditions. Recent macrophage-based therapeutic approaches, including delivery of ex-vivo-activated macrophages and pharmacological strategies, are discussed. Specifically, strategies to silence key regulator genes and repolarize wound macrophages to the M2 phenotype are highlighted, along with their potential future clinical translation.

MOLECULAR THERAPY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Wound-Healing and Antibacterial Activity of the Quercetin-4-Formyl Phenyl Boronic Acid Complex against Bacterial Pathogens of Diabetic Foot Ulcer

Hafiz Muhammad Usman Abid et al.

Summary: This study aims to enhance wound healing and antibacterial effects in diabetic foot complications using a newly synthesized antimicrobial agent. The results show that the esterified complex of quercetin with 4-formyl phenyl boronic acid (4FPBA-Q) exhibits stronger antibacterial activity and promotes wound healing in infected diabetic rats.

ACS OMEGA (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Molecular mechanism of VEGF and its role in pathological angiogenesis

Ajmal Ahmad et al.

Summary: This review article summarizes the significant scientific contributions made in the past seven decades regarding the implications of vascular endothelial-derived growth factor (VEGF) in angiogenesis processes. It highlights the role of VEGF in pathological conditions and its potential as a therapeutic target for managing cancers and intraocular neovascular disorders. The article also emphasizes the need for further research and development of alternative strategies in the management of VEGF-mediated pathological angiogenesis. Additionally, it discusses the emerging field of therapeutic angiogenesis for the treatment of ischemic disorders.

JOURNAL OF CELLULAR BIOCHEMISTRY (2022)

Add to Collection

Article Endocrinology & Metabolism

Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport

Javier Florido et al.

Summary: This study found that melatonin induces ROS production by driving mitochondrial reverse electron transport (RET), thereby mediating apoptosis in head and neck cancer cells. Melatonin-induced changes in tumoral metabolism lead to increased mitochondrial activity, which in turn induces ROS production.

JOURNAL OF PINEAL RESEARCH (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy

Weidong Qi et al.

Summary: This review explores the biological activities of quercetin, including its antioxidant and antibacterial properties, intervention effects on pesticide poisoning, detoxification process, and its potential in reducing mycotoxin toxicity. The harmful effects of heavy metal poisoning on quercetin application are also evaluated. This review provides valuable insights for the clinical application of quercetin.

MOLECULES (2022)

Add to Collection

Review Cell Biology

Macrophage-Mediated Inflammation in Skin Wound Healing

Alireza Hassanshahi et al.

Summary: This review discusses the role and mechanisms of macrophages in skin wound healing, including cellular and molecular aspects such as subtypes, metabolism, plasticity, and epigenetics. The interactions between macrophages and factors important for wound healing are also highlighted.

CELLS (2022)

Add to Collection

Review Pharmacology & Pharmacy

New Horizons of Macrophage Immunomodulation in the Healing of Diabetic Foot Ulcers

Ching-Wen Lin et al.

Summary: Diabetic foot ulcers are costly and problematic complications of diabetes. The chronicity of these ulcers presents a challenge in treatment. Modulating the activity of M1 and M2 macrophages seems to be an effective approach in improving the healing process of DFUs.

PHARMACEUTICS (2022)

Add to Collection

Article Medicine, Research & Experimental

Healing potential of Spirulina platensis for skin wounds by modulating bFGF, VEGF, TGF-β1 and α-SMA genes expression targeting angiogenesis and scar tissue formation in the rat model

Zizy Elbialy et al.

Summary: The study found that topically applied Spirulina can promote wound healing by reducing inflammatory cell infiltration, promoting angiogenesis and epithelialization, inhibiting fibrosis, and aiding in wound contraction. This suggests that Spirulina may be used as a biomedical application to treat various skin wounds and may provide a potential molecular basis for future antifibrotic agents against scar formation.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Add to Collection

Article Pharmacology & Pharmacy

Polyherbal combination for wound healing: Matricaria chamomilla L. and Punica granatum L.

Somayeh Niknam et al.

Summary: The study revealed that the methanol extracts of pomegranate and chamomile flowers exhibit high antioxidant and wound healing activities, likely due to their rich phytochemical content. In wound healing experiments, both single and combined treatments accelerated wound closure, with the combined form showing better results.

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Add to Collection

Review Cell Biology

Chronic Diabetic Wounds and Their Treatment with Skin Substitutes

Jordan Holl et al.

Summary: With the increasing prevalence of type 2 diabetes mellitus, the management of chronic diabetic wounds and ulcers has become a significant therapeutic challenge. Recent advancements in understanding wound healing mechanisms have led to the development of novel therapies, with a particular focus on biological dressings.

CELLS (2021)

Add to Collection

Article

Plant-Based Natural Products For Wound Healing: A Critical Review

Shalini Ramalingam et al.

Current Drug Research Reviews (2021)

Add to Collection

Article Immunology

Topical application of quercetin improves wound repair and regeneration in diabetic rats

Vinay Kant et al.

Summary: The study showed that 0.3% quercetin ointment can accelerate wound closure and promote cell regeneration and repair in diabetic rats, while reducing inflammation response.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2021)

Add to Collection

Review Plant Sciences

The role of quercetin in plants

Priyanka Singh et al.

Summary: Flavonoids are a special category of hydroxylated phenolic compounds with an aromatic ring structure, and quercetin is a subclass known for its bioactive properties in promoting plant physiological processes and antioxidant functions. Quercetin plays a crucial role in enhancing various physiological and biochemical processes in plants under stress and non-stress conditions, while also showing potential in mitigating biotic and abiotic stresses such as salt, heavy metal, and UV stress. Additionally, the biosynthesis of flavonoids, their signaling pathways, and quercetin's involvement in plant signaling are discussed in this review.

PLANT PHYSIOLOGY AND BIOCHEMISTRY (2021)

Add to Collection

Article Surgery

Quercetin Promotes Diabetic Wound Healing via Switching Macrophages From M1 to M2 Polarization

Jia Fu et al.

JOURNAL OF SURGICAL RESEARCH (2020)

Add to Collection

Article Allergy

Quercetin Improves Inflammation, Oxidative Stress, and Impaired Wound Healing in Atopic Dermatitis Model of Human Keratinocytes

Burcin Beken et al.

PEDIATRIC ALLERGY IMMUNOLOGY AND PULMONOLOGY (2020)

Add to Collection

Article Immunology

Antibiotics Affect ROS Production and Fibroblast Migration in an In-vitro Model of Sinonasal Wound Healing

Michael Gouzos et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Add to Collection

Article Pharmacology & Pharmacy

length Quercetin loaded chitosan tripolyphosphate nanoparticles accelerated cutaneous wound healing in Wistar rats

Abhinav Choudhary et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Add to Collection

Article Hematology

Defining an Upstream VEGF (Vascular Endothelial Growth Factor) Priming Signature for Downstream Factor-Induced Endothelial Cell-Pericyte Tube Network Coassembly

Stephanie L. K. Bowers et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

Add to Collection

Article Cell Biology

Quercetin accelerated cutaneous wound healing in rats by modulation of different cytokines and growth factors

Vinay Kant et al.

GROWTH FACTORS (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Wound healing: cellular mechanisms and pathological outcomes

Holly N. Wilkinson et al.

OPEN BIOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Effects of Rutin on Wound Healing in Hyperglycemic Rats

Li-You Chen et al.

ANTIOXIDANTS (2020)

Add to Collection

Review Ophthalmology

Fibrocytes, Wound Healing, and Corneal Fibrosis

Rodrigo Carlos de Oliveira et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2020)

Add to Collection

Review Pharmacology & Pharmacy

Therapeutic strategies for enhancing angiogenesis in wound healing

Austin P. Veith et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

Dong Xu et al.

MOLECULES (2019)

Add to Collection

Review Public, Environmental & Occupational Health

Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies

Laura Martinengo et al.

ANNALS OF EPIDEMIOLOGY (2019)

Add to Collection

Review Chemistry, Medicinal

Molecular Concept of Diabetic wound Healing: Effective Role of Herbal Remedies

Amro Mohamed Soliman et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2019)

Add to Collection

Review Physiology

WOUND HEALING: A CELLULAR PERSPECTIVE

Melanie Rodrigues et al.

PHYSIOLOGICAL REVIEWS (2019)

Add to Collection

Article Medicine, Research & Experimental

Quercetin and low level laser therapy promote wound healing process in diabetic rats via structural reorganization and modulatory effects on inflammation and oxidative stress

Osama M. Ahmed et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Add to Collection

Article Dermatology

Topical application of quercetin improves wound healing in pressure ulcer lesions

Guimei Yin et al.

EXPERIMENTAL DERMATOLOGY (2018)

Add to Collection

Article Plant Sciences

In vivo wound-healing activity of Euphorbia characias subsp wulfenii: Isolation and quantification of quercetin glycosides as bioactive compounds

Serkan Ozbilgin et al.

JOURNAL OF ETHNOPHARMACOLOGY (2018)

Add to Collection

Article Medicine, Research & Experimental

Effects of Tumor Necrosis Factor α (TNF-α) and Interleukina 10 (IL-10) on Intercellular Cell Adhesion Molecule-1 (ICAM-1) and Cluster of Differentiation 31 (CD31) in Human Coronary Artery Endothelial Cells

Mingming Xue et al.

MEDICAL SCIENCE MONITOR (2018)

Add to Collection

Review Food Science & Technology

Quercetin in Food: Possible Mechanisms of Its Effect on Memory

Fatemeh Babaei et al.

JOURNAL OF FOOD SCIENCE (2018)

Add to Collection

Article Dermatology

Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process

Christopher Dunnill et al.

INTERNATIONAL WOUND JOURNAL (2017)

Add to Collection

Article Medicine, Research & Experimental

The impact of quercetin on wound healing relates to changes in αV and β1 integrin expression

Karen M. Doersch et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing

Mark Hesketh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Add to Collection

Article Biochemistry & Molecular Biology

The role of α-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling

Arti V. Shinde et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

Add to Collection

Article Biochemistry & Molecular Biology

NADPH oxidase 4 deficiency leads to impaired wound repair and reduced dityrosine-crosslinking, but does not affect myofibroblast formation

Dominik Levigne et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Add to Collection

Article Oncology

Low-grade inflammatory polarization of monocytes impairs wound healing

Ruoxi Yuan et al.

JOURNAL OF PATHOLOGY (2016)

Add to Collection

Article Cell Biology

Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis

Michael K. Lichtman et al.

WOUND REPAIR AND REGENERATION (2016)

Add to Collection

Article Pharmacology & Pharmacy

Wound healing activity of Delonix elata stem bark extract and its isolated constituent quercetin-3-rhamnopyranosyl-(1-6) glucopyranoside in rats

Pradeepa Krishnappa et al.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2016)

Add to Collection

Review Dermatology

Cellular and molecular mechanisms of repair in acute and chronic wound healing

P. Martin et al.

BRITISH JOURNAL OF DERMATOLOGY (2015)

Add to Collection

Article Health Care Sciences & Services

SYRCLE's risk of bias tool for animal studies

Carlijn R. Hooijmans et al.

BMC MEDICAL RESEARCH METHODOLOGY (2014)

Add to Collection

Review Cell Biology

Remodelling the extracellular matrix in development and disease

Caroline Bonnans et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Add to Collection

Article Plant Sciences

Wound healing potential of Sambucus ebulus L. leaves and isolation of an active component, quercetin 3-O-glucoside

Ipek Pesin Suntar et al.

JOURNAL OF ETHNOPHARMACOLOGY (2010)

Add to Collection

Review Nutrition & Dietetics

Basics in nutrition and wound healing

Thomas Wild et al.

NUTRITION (2010)

Add to Collection

Article Surgery

Liposomal gene transfer of keratinocyte growth factor improves wound healing by altering growth factor and collagen expression

Clifford T. Pereira et al.

JOURNAL OF SURGICAL RESEARCH (2007)

Add to Collection

© Peeref 2019-2024. All rights reserved.