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ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2022)

Article Microbiology

Is the Pendulum of Antimicrobial Drug Resistance Swinging Back after COVID-19?

Francesca Serapide et al.

Summary: The study compared the prevalence of ESKAPE multidrug-resistant bacterial infections between COVID-19 affected and unaffected patients, and found a higher frequency of MDR ESKAPE bacteria in COVID-19 patients admitted to the ICU. Acinetobacter baumannii was identified as the main pathogen in COVID-19 patients and was associated with a higher mortality rate, highlighting the importance of infection control measures in combating antimicrobial resistance.

MICROORGANISMS (2022)

Article Infectious Diseases

Antimicrobial Resistance Research Collaborations in Asia: Challenges and Opportunities to Equitable Partnerships

Pami Shrestha et al.

Summary: This study aimed to identify and understand the challenges and opportunities for collaborative antimicrobial resistance (AMR) research in Asia. Factors influencing research collaborations were found to be the multi-dimensional nature of AMR, limited funds, different AMR research priorities in Asian countries, absence of Asia-centric AMR leadership, lack of trust and unequal power relationships between researchers, and the negative impact of the COVID-19 pandemic. The study also highlighted opportunities such as researchers' willingness to collaborate, the formation of networks, and the prioritization of the One Health paradigm for AMR research.

ANTIBIOTICS-BASEL (2022)

Review Infectious Diseases

Resistance to Ceftazidime/Avibactam, Meropenem/Vaborbactam and Imipenem/Relebactam in Gram-Negative MDR Bacilli: Molecular Mechanisms and Susceptibility Testing

Paolo Gaibani et al.

Summary: Multidrug resistance (MDR) is a serious global threat due to the rapid spread of MDR pathogens and limited treatment options. New beta-lactams/beta-lactamase inhibitor combinations (beta L-beta LICs) have shown promise for treating MDR Gram-negative infections. However, resistance to these novel molecules has started to emerge. This review summarizes the mechanisms of resistance to ceftazidime/avibactam, meropenem/vaborbactam, and imipenem/relebactam in MDR Gram-negative microorganisms, with a focus on antimicrobial activities and resistance traits related to novel beta L-PLICs. The detection methods for antimicrobial susceptibility testing of these molecules are also discussed.

ANTIBIOTICS-BASEL (2022)

Review Infectious Diseases

Triclosan: A Small Molecule with Controversial Roles

Maria Stefania Sinicropi et al.

Summary: Triclosan (TCS) is a widely used broad-spectrum antimicrobial agent in personal care products. Its toxicity to mammals and the adverse effects of long-term exposure are still unclear. Recent reports suggest its potential use in cancer treatment and cutaneous leishmaniasis.

ANTIBIOTICS-BASEL (2022)

Article Infectious Diseases

A new One Health Joint Action Plan

Timothy Jesudason

LANCET INFECTIOUS DISEASES (2022)

Review Biochemistry & Molecular Biology

Drugs for COVID-19: An Update

Jessica Ceramella et al.

Summary: This review provides an overview of the current pharmacological therapies used for the treatment of COVID-19, highlighting the ongoing need for more effective vaccines, therapies, and other solutions.

MOLECULES (2022)

Article Microbiology

New Perspectives on Antimicrobial Agents: Imipenem-Relebactam

J. Nicholas O'Donnell et al.

Summary: Imipenem/cilastatin/relebactam is a novel combination medication with expanded activity against carbapenem-resistant non-Morganellaceae Enterobacterales and difficult-to-treat Pseudomonas aeruginosa. It has been approved for the treatment of certain bacterial infections when alternative treatments are limited. Further research is needed to determine its optimal role in treating highly resistant Gram-negative infections.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2022)

Article Public, Environmental & Occupational Health

Parents' awareness of antimicrobial resistance: a qualitative study utilising the Health Belief Model in Perth, Western Australia

Aaron Lapuz Alejandro et al.

Summary: This study examines the local factors influencing parents' responsible use of antibiotics for children in Perth. The results show that while parents have awareness of the indications of antibiotics, they lack understanding of antimicrobial resistance (AMR) and tend to overvalue antibiotics. It is suggested that promoting parent empowerment and participation in decision-making, as well as maintaining a positive relationship with healthcare providers, are important strategies to encourage appropriate antibiotic use.

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH (2022)

Review Infectious Diseases

Ceftazidime/Avibactam in Ventilator-Associated Pneumonia Due to Difficult-to-Treat Non-Fermenter Gram-Negative Bacteria in COVID-19 Patients: A Case Series and Review of the Literature

Giulia Jole Burastero et al.

Summary: Ventilator-associated pneumonia (VAP) is a major threat in critically ill COVID-19 patients, with a higher incidence rate and significant mortality. Pseudomonas aeruginosa is the most common pathogen, but other uncommon gram-negative bacteria such as Burkholderia cepacea and Stenotrophomonas maltophilia have also emerged. Ceftazidime/avibactam (CZA) is considered an effective treatment option, especially for carbapenem-resistant microorganisms. This report describes the use of CZA in a case series of COVID-19 patients with VAP caused by difficult-to-treat (DTT) gram-negative bacteria, including uncommon pathogens like Burkholderia cepacea and Stenotrophomonas maltophilia.

ANTIBIOTICS-BASEL (2022)

Article Infectious Diseases

Clinical Impact of COVID-19 on Multi-Drug-Resistant Gram-Negative Bacilli Bloodstream Infections in an Intensive Care Unit Setting: Two Pandemics Compared

Francesco Cogliati Dezza et al.

Summary: This study evaluates the impact of COVID-19 on MDR-GN bloodstream infections in an ICU setting. The study finds that COVID-19 patients have a higher incidence of MDR-GN infections and experience more severe conditions and higher mortality rates.

ANTIBIOTICS-BASEL (2022)

Article Medicine, General & Internal

Co-Infections and Superinfections in COVID-19 Critically Ill Patients Are Associated with CT Imaging Abnormalities and the Worst Outcomes

Nicolo Brandi et al.

Summary: Bacterial and fungal co-infections and superinfections are frequent in COVID-19 patients admitted to the ICU and are associated with worse outcomes. Imaging plays an important role in monitoring critically ill COVID-19 patients and may help detect these complications, suggesting further laboratory investigations.

DIAGNOSTICS (2022)

Editorial Material Infectious Diseases

The pandemic legacy of antimicrobial resistance in the USA

Jay Patel et al.

LANCET MICROBE (2022)

Review Microbiology

Ceftolozane/tazobactam for the treatment of bacteremia: a systematic literature review (SLR)

Z. S. Khankhel et al.

Summary: Bloodstream infections, especially those caused by resistant pathogens, present significant challenges in management. This systematic literature review examines the utilization of ceftolozane/tazobactam in bacteremia and suggests that it may be beneficial in improving outcomes. However, the limited data and high heterogeneity call for further research to understand the exact effects of this treatment.

ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS (2022)

Review Environmental Sciences

Antibiotic Resistance during COVID-19: A Systematic Review

Hadi Jaber Al Sulayyim et al.

Summary: This study explored the impact of the COVID-19 pandemic on antibiotic resistance (AR) and found that AR has increased during this period. Gram-negative bacteria such as Acinetobacter baumannii and Klebsiella pneumoniae showed high resistance to tested antibiotics, while Gram-positive bacteria like Staphylococcus aureus and Enterococcus faecium exhibited resistance to certain antibiotics. Risk factors for high levels of AR during COVID-19 included self-antibiotic medication, empirical antibiotic administration, and antibiotics prescribed by general practitioners.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

Article Microbiology

Clinical and genomic characterization of hypervirulent Klebsiella pneumoniae (hvKp) infections via passive surveillance in Southern California, 2020-2022

Edwin Kamau et al.

Summary: The study found that hypervirulent Klebsiella pneumoniae infections were more common than expected in Southern California, presenting with various symptoms, occasionally mimicking tumors, and even co-infecting a COVID-19 patient. Genomic analysis showed genetic diversity, underscoring the importance of heightened awareness, rapid diagnosis, and robust surveillance programs for hvKp infections.

FRONTIERS IN MICROBIOLOGY (2022)

Review Infectious Diseases

Les miserables: a Parallel Between Antimicrobial Resistance and COVID-19 in Underdeveloped and Developing Countries

Genesy Perez Jorge et al.

Summary: This review discusses the misuse of antibiotics in patients with COVID-19 and its impact on the spread of multidrug-resistant bacteria. The study found that bacterial infections are relatively rare in COVID-19 patients, yet most of these patients still receive antibiotic treatments. The review highlights factors such as overprescription of antibiotics, self-medication, and lack of adequate diagnostic tests that contribute to inappropriate antibiotic use and the increase in antibiotic resistance. Strengthening epidemiological surveillance of hospital isolates and improving antibiotic prescribing are crucial.

CURRENT INFECTIOUS DISEASE REPORTS (2022)

Article Infectious Diseases

Multidrug resistant bacterial infections in severely ill COVID-19 patients admitted in a national referral and teaching hospital, Kenya

Jeniffer Munyiva Mutua et al.

Summary: This study evaluated the etiologies, antimicrobial resistance profiles, risk factors, and outcomes of bacterial infections in severely ill COVID-19 patients. The study found that at least 44.2% of the sampled patients had bacterial infections, with multidrug-resistant strains being predominant and males being more susceptible to bacterial infection. Elderly patients, non-SARS-CoV-2 vaccination, intensive care unit admission, and long hospital stays were associated with poor outcomes.

BMC INFECTIOUS DISEASES (2022)

Article Medicine, General & Internal

Investigation of Antibiotic Resistance Profiles and Carbapenemase Resistance Genes in Acinetobacter Baumannii Strains Isolated From Clinical Samples

Osman Karabay et al.

Summary: This study investigated the antibiotic resistance profiles of A. baumannii strains isolated from different clinics of a hospital and identified the class D beta-lactamase resistance genes causing carbapenem resistance. The results showed that colistin, tigecycline, and amikacin were the most effective antibiotics for carbapenem-resistant A. baumannii isolates. The prevalence of the OXA-24 enzyme gene was higher in this study compared to other similar studies.

EUROPEAN JOURNAL OF THERAPEUTICS (2022)

Article Medicine, Research & Experimental

The COVID-19 pandemic: a threat to antimicrobial resistance containment

Raspail C. Founou et al.

Summary: The COVID-19 pandemic has led to widespread misuse of antibiotics, which is likely to significantly increase antimicrobial resistance globally. Decision-makers need to consider the hidden threat of antimicrobial resistance, exacerbated by improper antibiotic use in treating severe COVID-19 patients, in addition to the expanding COVID-19 pandemic.

FUTURE SCIENCE OA (2021)

Article Infectious Diseases

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study

Clark D. Russell et al.

Summary: Microbiologically confirmed bacterial infections are rare in patients admitted with COVID-19, mostly being secondary infections. Gram-negative organisms and S aureus are the predominant pathogens. Antimicrobial use is frequent, but can be intervened with stewardship measures.

LANCET MICROBE (2021)

Article Medicine, General & Internal

COVID-19 impact on the understanding of infection prevention and control measures

Massimo Sartelli

BANGLADESH JOURNAL OF MEDICAL SCIENCE (2021)

Review Infectious Diseases

Antibiotic prescribing in patients with COVID-19: rapid review and meta-analysis

Bradley J. Langford et al.

Summary: The study estimated that approximately three-quarters of patients with COVID-19 receive antibiotic treatment, which is significantly higher than the estimated prevalence of bacterial co-infection. This suggests a potential for high rates of unnecessary antibiotic use in patients with COVID-19.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

Article Infectious Diseases

Antimicrobial resistance: A challenge awaiting the post-COVID-19 era

Tekle Airgecho Lobie et al.

Summary: Exposure of microbes to pharmaceutical and non-pharmaceutical agents contributes to antibiotic resistance development, and the risks and consequences of extensive disinfectant use during the COVID-19 pandemic are still unclear. Some disinfectants contain genotoxic chemicals that damage microbial DNA, leading to mutations that induce antimicrobial resistance. Additionally, restricted access to health services due to COVID-19 precautions poses challenges for the study of antimicrobial resistance.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

Article Public, Environmental & Occupational Health

The interrelationships between antimicrobial resistance, COVID-19, past, and future pandemics

Hyacinth O. Ukuhor

Summary: The COVID-19 pandemic has resulted in high morbidity and mortality rates, with some cases showing resistance to antimicrobials leading to worse outcomes. Antimicrobial-resistant co-infections have been a significant factor in clinically significant mortality. Various factors such as misuse of antimicrobials, international travel, healthcare financing issues, human use/misuse, agricultural production, and climate change are determinants of antimicrobial resistance.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2021)

Article Infectious Diseases

Clonal dispersion of Acinetobacter baumannii in an intensive care unit designed to patients COVID-19

Emilio Mariano Duran-Manuel et al.

Summary: The study identified and characterized the distribution and clonal spread of ESKAPE bacteria in medical devices, patients, and medical personnel in the ICU for COVID-19 patients at Hospital Juarez de Mexico. Acinetobacter baumannii and Staphylococcus aureus were the predominant ESKAPE members, with clonal spread of A. baumannii (AdeABCRS+) emphasizing the importance of implementing proper disinfection practices and management for COVID-19 patients.

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES (2021)

Review Biology

Antimicrobial resistance and COVID-19: Intersections and implications

Gwenan M. Knight et al.

Summary: The impact of the COVID-19 pandemic on antimicrobial resistance is two-fold, potentially reducing resistance through increased hand hygiene and decreased international travel, but also exacerbating it through increased antibiotic use. The dynamics of antimicrobial resistance remain uncertain at this stage, highlighting the need for global collaboration to address this intersecting public health challenge.

ELIFE (2021)

Review Virology

Impact of SARS-CoV-2 Epidemic on Antimicrobial Resistance: A Literature Review

Francesco Vladimiro Segala et al.

Summary: The COVID-19 pandemic has led to a significant disruption of healthcare systems and practices, resulting in a high incidence of infections caused by multidrug-resistant pathogens. Inappropriate antimicrobial exposure and discontinuation of infection control measures may have contributed to the selection and spread of drug-resistant bacteria and fungi.

VIRUSES-BASEL (2021)

Review Infectious Diseases

A global perspective on the convergence of hypervirulence and carbapenem resistance in Klebsiella pneumoniae

Peng Lan et al.

Summary: Hypervirulence and carbapenem resistance have emerged as two distinct evolutionary directions for Klebsiella pneumoniae, posing a great threat in clinical settings. CR-hvKP strains, integrating both phenotypes, have become increasingly prevalent globally, primarily in Asia. The mechanisms for the emergence of CR-hvKP can be summarised by three patterns, and continued surveillance of their dissemination should be highly prioritised.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2021)

Review Multidisciplinary Sciences

The silent pandemic: Emergent antibiotic resistances following the global response to SARS-CoV-2

Andrew R. Mahoney et al.

Summary: The importance of rapid development of vaccines and antivirals due to the ongoing SARS-CoV-2 pandemic has been highlighted, but the increased use of antibacterial products and treatments poses an underreported threat of antibiotic resistances emergence.

ISCIENCE (2021)

Review Microbiology

Clinical Epidemiology, Risk Factors, and Control Strategies of Klebsiella pneumoniae Infection

De Chang et al.

Summary: Klebsiella species can cause infections at multiple sites, with a higher likelihood in individuals with preexisting health conditions. Klebsiella pneumoniae has become a major international pathogen due to the rise of hypervirulent and carbapenem-resistant strains. Understanding risk factors, prevention strategies, and treatment options is crucial in combating multidrug-resistant Klebsiella infections.

FRONTIERS IN MICROBIOLOGY (2021)

Article Immunology

Infectious Diseases Society of America Guidance on the Treatment of Extended-Spectrum β-lactamase Producing Enterobacterales (ESBL-E), Carbapenem-Resistant Enterobacterales (CRE), and Pseudomonas aeruginosa with Difficult-to-Treat Resistance (DTR-P. aeruginosa)

Pranita D. Tamma et al.

Summary: This guidance document provides recommendations for the treatment of antimicrobial-resistant infections commonly encountered in US hospitals, focusing on ESBL-E, CRE, and DTR-P. aeruginosa. It includes preferred and alternative treatment recommendations, discussion on empiric treatment selection and management considerations, and will be periodically updated. The current version is as of 17 September 2020, with plans to expand recommendations to include other problematic gram-negative pathogens in future versions.

CLINICAL INFECTIOUS DISEASES (2021)

Review Microbiology

Bacterial Antibiotic Resistance: The Most Critical Pathogens

Giuseppe Mancuso et al.

Summary: Overuse and misuse of antibiotics have accelerated the spread of antibiotic-resistant bacteria, leading to at least 700,000 deaths worldwide each year. Without new treatments, this number could rise to 10 million by 2050, posing a serious global health threat.

PATHOGENS (2021)

Review Biochemistry & Molecular Biology

The Different Facets of Triclocarban: A Review

Domenico Iacopetta et al.

Summary: Triclocarban, a polychlorinated aromatic antimicrobial agent, has been widely used in various products for over 50 years, but concerns about its endocrine disruptive properties have led to a ban by the U.S. Food and Drug Administration in hand and body washes. Efforts are now being made to find alternative antimicrobial compounds.

MOLECULES (2021)

Review Biochemistry & Molecular Biology

Bacterial Coinfections in Coronavirus Disease 2019

Lars F. Westblade et al.

Summary: Bacterial coinfections are not common in patients with COVID-19 upon admission, but may frequently occur during hospitalization. Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae are common pathogens. Most patients hospitalized with COVID-19 do not need antibacterial therapy and diagnostic testing for bacterial infections upon admission, but clinicians should be vigilant for nosocomial infections.

TRENDS IN MICROBIOLOGY (2021)

Article Infectious Diseases

An unequivocal superbug: PDR Klebsiella pneumoniae with an arsenal of resistance and virulence factor genes

Ahmad Sleiman et al.

Summary: This study characterized two carbapenem-resistant K. pneumoniae strains from the same patient, revealing a high number of antimicrobial resistant genes and virulence factor genes which could potentially lead to life-threatening infections.

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES (2021)

Review Medicine, General & Internal

Carbapenem-Resistant Klebsiella pneumoniae Infections in ICU COVID-19 Patients-A Scoping Review

Wioletta Medrzycka-Dabrowska et al.

Summary: The study highlights the importance of paying attention to carbapenem-resistant Klebsiella pneumoniae infections in patients with COVID-19. Rational antibiotic therapy should be used to prevent the increase of bacterial resistance, along with continuous monitoring and surveillance of hospital infections caused by multidrug-resistant organisms.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Infectious Diseases

Impact of the COVID-19 pandemic on the surveillance, prevention and control of antimicrobial resistance: a global survey

Sara Tomczyk et al.

Summary: The survey on the global impact of COVID-19 on AMR among GLASS countries revealed reduced availability of healthcare and cleaning staff, which could bias AMR surveillance data. Additionally, most countries still lack complete data to measure the specific impact of COVID-19 on AMR rates.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

Review Biochemistry & Molecular Biology

Multidrug-resistant Acinetobacter baumannii as an emerging concern in hospitals

Susan Ibrahim et al.

Summary: Acinetobacter baumannii has become a major concern in the scientific community due to its extensive antimicrobial resistance. The acquisition of mobile genetic elements has led to the prevalence of multidrug-resistant strains, including carbapenem-resistant A. baumannii (CR-Ab), which is a worldwide problem. Plasmid-mediated resistance has caused outbreaks of extensively drug-resistant A. baumannii (XDR-Ab), highlighting the importance of proper monitoring, prevention, and treatment to control infections.

MOLECULAR BIOLOGY REPORTS (2021)

Article Microbiology

Antimicrobial susceptibility patterns of respiratory Gram-negative bacterial isolates from COVID-19 patients in Switzerland

Marina Gysin et al.

Summary: Considerable levels of antimicrobial resistance may contribute to bacterial superinfections in ventilated COVID-19 patients, requiring consecutive adaptation of antibiotic therapy. High susceptibility to amikacin and apramycin indicates that aminoglycosides can be effective second-line treatments for ventilator-associated bacterial pneumonia, with effective drug exposure in the lungs being crucial. Genotypic analysis of Pseudomonas aeruginosa isolates revealed a frameshift mutation in the transcriptional regulator nalC associated with a change in susceptibility to beta-lactams and quinolones.

ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS (2021)

Review Environmental Sciences

The Pandemic beyond the Pandemic: A Scoping Review on the Social Relationships between COVID-19 and Antimicrobial Resistance

Luisa Toro-Alzate et al.

Summary: Social sciences play a crucial role in combating antimicrobial resistance and COVID-19 by addressing social issues such as changes in antibiotic prescription behavior and misinformation control. Effective interventions can help mitigate the impact of these public health challenges.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Review Microbiology

Acinetobacter baumannii Infections in Times of COVID-19 Pandemic

Karyne Rangel et al.

Summary: The COVID-19 pandemic has led to overuse of antimicrobials in critically ill patients, increasing the incidence of pathogens like Acinetobacter baumannii in ICUs. Patients with COVID-19 are at risk of secondary bacterial infections due to comorbidities and immune dysfunction.

PATHOGENS (2021)

Article Infectious Diseases

Paradigm Shift in Antimicrobial Resistance Pattern of Bacterial Isolates during the COVID-19 Pandemic

Vikas Saini et al.

Summary: The study explored the antimicrobial resistance pattern of bacterial agents isolated from COVID-19 patients and found an increase in AMR among isolates obtained during the pandemic compared to pre-COVID-19 times. The overuse of antibiotics created opportunities for bacterial pathogens to develop resistance mechanisms, highlighting the need for proper antibiotic use and infection control practices to combat AMR effectively.

ANTIBIOTICS-BASEL (2021)

Article Infectious Diseases

The potential impact of the COVID-19 pandemic on global antimicrobial and biocide resistance: an AMR Insights global perspective

Shamshul Ansari et al.

Summary: The COVID-19 pandemic poses a potential impact on global antimicrobial resistance, with critically ill patients possibly leading to overuse of antibiotics and mild cases also potentially misusing antibiotics. There is a need for increased awareness of antimicrobial resistance, proper antibiotic use, and strengthening of infection control and diagnostics.

JAC-ANTIMICROBIAL RESISTANCE (2021)

Letter Tropical Medicine

The use of antibiotics in COVID-19 management: a rapid review of national treatment guidelines in 10 African countries

Yusuff Adebayo Adebisi et al.

Summary: Antimicrobial resistance poses a hidden threat exacerbated by the widespread and unnecessary use of antibiotics, leading to the emergence and spread of resistant pathogens. Despite COVID-19 being a viral disease, various antibiotics are recommended for use in the management of the disease in African countries, highlighting the need for prudent and judicious use of antibiotics.

TROPICAL MEDICINE AND HEALTH (2021)

Article Infectious Diseases

Secondary Infections in Hospitalized COVID-19 Patients: Indian Experience

Sonam Vijay et al.

Summary: A study in India found that 3.6% of hospitalized COVID-19 patients developed secondary bacterial or fungal infections, with a mortality rate of 56.7% among those with secondary infections.

INFECTION AND DRUG RESISTANCE (2021)

Article Immunology

COVID-19 and Fatal Sepsis Caused by Hypervirulent Klebsiella pneumoniae, Japan, 2020

Tomohiro Hosoda et al.

Summary: In patients with coronavirus disease who deteriorate rapidly, co-infections by bacterial and fungal pathogens, including hypervirulent Klebsiella pneumoniae in eastern Asia, should be considered in the differential diagnosis.

EMERGING INFECTIOUS DISEASES (2021)

Review Medicine, General & Internal

Hypervirulent Klebsiella pneumoniae - clinical and molecular perspectives

J. E. Choby et al.

JOURNAL OF INTERNAL MEDICINE (2020)

Editorial Material Microbiology

Enterobacteriaceae? Enterobacterales? What Should We Call Enteric Gram-Negative Bacilli? A Micro-Comic Strip

Alexander J. McAdam

JOURNAL OF CLINICAL MICROBIOLOGY (2020)

Editorial Material Medicine, General & Internal

The rise of hyper-virulence

Marie-Stephanie Aschtgen et al.

JOURNAL OF INTERNAL MEDICINE (2020)

Review Infectious Diseases

The Lancet Infectious Diseases Commission on antimicrobial resistance: 6 years later

Ramanan Laxminarayan et al.

LANCET INFECTIOUS DISEASES (2020)

Review Infectious Diseases

Meropenem/vaborbactam: a next generation β-lactam β-lactamase inhibitor combination

Andrea Novelli et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2020)

Review Chemistry, Multidisciplinary

Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections

Yu-Xuan Ma et al.

ADVANCED SCIENCE (2020)

Article Public, Environmental & Occupational Health

Epidemiology of Carbapenem-resistant Enterobacteriaceae in Egyptian intensive care units using National Healthcare-associated Infections Surveillance Data, 2011-2017

Sara Kotb et al.

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2020)

Editorial Material Medicine, General & Internal

Managing COVID-19 in Low- and Middle-Income Countries

Joost Hopman et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Editorial Material Infectious Diseases

COVID-19 and the potential long-term impact on antimicrobial resistance

Timothy M. Rawson et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

Review Infectious Diseases

Co-infections in people with COVID-19: a systematic review and meta-analysis

Louise Lansbury et al.

JOURNAL OF INFECTION (2020)

Review Immunology

Co-infections among patients with COVID-19: The need for combination therapy with non-anti-SARS-CoV-2 agents?

Chih-Cheng Lai et al.

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION (2020)

Editorial Material Microbiology

The Novel Coronavirus COVID-19 Outbreak: Global Implications for Antimicrobial Resistance

Aimee K. Murray

FRONTIERS IN MICROBIOLOGY (2020)

Review Infectious Diseases

How CRISPR-Cas System Could Be Used to Combat Antimicrobial Resistance

Pourya Gholizadeh et al.

INFECTION AND DRUG RESISTANCE (2020)

Review Infectious Diseases

Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis

Bradley J. Langford et al.

CLINICAL MICROBIOLOGY AND INFECTION (2020)

Editorial Material Public, Environmental & Occupational Health

Tackling antimicrobial resistance in the COVID-19 pandemic

Haileyesus Getahun et al.

BULLETIN OF THE WORLD HEALTH ORGANIZATION (2020)

Article Immunology

Secondary Bacterial Infections in Critical Ill Patients With Coronavirus Disease 2019

Yiqi Fu et al.

OPEN FORUM INFECTIOUS DISEASES (2020)

Article Virology

Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China

Guqin Zhang et al.

JOURNAL OF CLINICAL VIROLOGY (2020)

Editorial Material Medicine, General & Internal

Confronting antimicrobial resistance beyond the COVID-19 pandemic and the 2020 US election

Steffanie A. Strathdee et al.

LANCET (2020)

Editorial Material Multidisciplinary Sciences

COVID-19 in Africa: Dampening the storm?

Moustapha Mbow et al.

SCIENCE (2020)

Letter Infectious Diseases

Co-infections: potentially lethal and unexplored in COVID-19

Michael J. Cox et al.

LANCET MICROBE (2020)

Review Microbiology

Hypervirulent Klebsiella pneumoniae

Thomas A. Russo et al.

CLINICAL MICROBIOLOGY REVIEWS (2019)

Review Microbiology

Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review

Mansura S. Mulani et al.

FRONTIERS IN MICROBIOLOGY (2019)

Review Infectious Diseases

Eravacycline, a newly approved fluorocycline

Young Ran Lee et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2019)

Review Infectious Diseases

Epidemiology of carbapenem-resistant Gram-negative infections globally

Adrian J. Brink

CURRENT OPINION IN INFECTIOUS DISEASES (2019)

Article Immunology

Treatment Options for Carbapenem-resistant Gram-negative Bacterial Infections

Yohei Doi

CLINICAL INFECTIOUS DISEASES (2019)

Editorial Material Infectious Diseases

Public health burden of antimicrobial resistance in Europe

Evelina Tacconelli et al.

LANCET INFECTIOUS DISEASES (2019)

Review Pharmacology & Pharmacy

Plazomicin: A Next-Generation Aminoglycoside

Kristy M. Shaeer et al.

PHARMACOTHERAPY (2019)

Article Microbiology

Hypervirulent Klebsiella pneumoniae, a 5-year study in a French ICU

Cedric Rafat et al.

JOURNAL OF MEDICAL MICROBIOLOGY (2018)

Review Immunology

Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae

Rebekah M. Martin et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2018)

Article Ophthalmology

Rising trends of endogenous Klebsiella pneumoniae endophthalmitis in Australia

Capucine Odouard et al.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2017)

Article Infectious Diseases

Peculiar purulence: Hypervirulent Klebsiella pneumoniae causing pyomyositis

Okechukwu Mgbemena et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2017)

News Item Multidisciplinary Sciences

Drug-resistant bacteria ranked

Cassandra Willyard

NATURE (2017)

Article Infectious Diseases

Evaluation of carriage and environmental contamination by carbapenem-resistant Acinetobacter baumannii

A. Nutman et al.

CLINICAL MICROBIOLOGY AND INFECTION (2016)

Review Microbiology

Klebsiella pneumoniae: Going on the Offense with a Strong Defense

Michelle K. Paczosa et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2016)

Review Microbiology

Molecular pathogenesis of Klebsiella pneumoniae

Bei Li et al.

FUTURE MICROBIOLOGY (2014)

Article Public, Environmental & Occupational Health

Frequency of Klebsiella pneumoniae Carbapenemase (KPC)-Producing and Non-KPC-Producing Klebsiella Species Contamination of Healthcare Workers and the Environment

Clare Rock et al.

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY (2014)

Review Infectious Diseases

Klebsiella pneumoniae liver abscess: a new invasive syndrome

L. Kristopher Siu et al.

LANCET INFECTIOUS DISEASES (2012)

Article Public, Environmental & Occupational Health

Control of an Outbreak of Carbapenem-Resistant Acinetobacter baumannii in Australia after Introduction of Environmental Cleaning with a Commercial Oxidizing Disinfectant

Michelle Doidge et al.

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY (2010)

Article Medicine, General & Internal

Bacteriology of war wounds at the time of injury

Clinton K. Murray et al.

MILITARY MEDICINE (2006)

Review Infectious Diseases

Tigecycline

GA Pankey

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2005)

Review Infectious Diseases

Emerging carbapenemases in Gram-negative aerobes

P Nordmann et al.

CLINICAL MICROBIOLOGY AND INFECTION (2002)