Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 22, Issue 13, Pages 1759-1762Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458515627205
Keywords
Multiple sclerosis; risk factor; sex hormones; testosterone; transgender; epidemiology
Categories
Funding
- English National Institute for Health Research
- Higher Education Funding Council for England Clinical Senior Lectureship Award
Ask authors/readers for more resources
Background: An altered balance of gonadal hormones in males with gender identity disorders (GIDs) may increase multiple sclerosis (MS) risk both inherently and secondary to treatment in undergoing male-to-female conversion. Objective: We investigated any association between GIDs and MS through analysis of record-linked hospital statistics. Method: Analysis of English Hospital Episode Statistics, 1999-2012. Results: The adjusted rate ratio (RR) of MS following GIDs in males was 6.63 (95% confidence interval (95% CI) = 1.81-17.01, p = 0.0002). The RR of MS following GIDs in females was 1.44 (95% CI = 0.47-3.37, p = 0.58). Conclusion: We report a strong association between GIDs and MS in male-to-females, supporting a potential role for low testosterone and/or feminising hormones on MS risk in males.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available