4.6 Article

Betapapillomaviruses in p16-Negative Vulvar Intraepithelial Lesions Associated with Squamous Cell Carcinoma

Related references

Note: Only part of the references are listed.
Article Pathology

Molecular landscape of vulvovaginal squamous cell carcinoma: new insights into molecular mechanisms of HPV-associated and HPV-independent squamous cell carcinoma

Abeer M. Salama et al.

Summary: The study found differences in genomic events between HPV-associated squamous cell carcinomas and HPV-independent SqCC, suggesting different characteristics in gene mutations between the two.

MODERN PATHOLOGY (2022)

Review Pathology

HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva

Carlos Parra-Herran et al.

Summary: Vulvar squamous cell carcinomas and their precursors are currently classified based on their association with HPV or TP53 mutations. However, there is a group of lesions that are independent of both HPV and mutant TP53. In this review, we provide a comprehensive description of these lesions and propose a new term, HPVi(p53wt) vaVIN, to better convey their pathology, neoplastic nature, and biological risk.

MODERN PATHOLOGY (2022)

Article Oncology

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD) and the European Federation for Colposcopy (EFC) consensus statements on pre-invasive vulvar lesions

Mario Preti et al.

Summary: The European societies have developed consensus statements on pre-invasive vulvar lesions to improve patient care. The treatment methods vary depending on the type of lesion, including excisional procedures, ablative procedures, and medical treatment. Regular follow-up and assessment are necessary after treatment.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2022)

Article Oncology

Significance of p53 and presence of differentiated vulvar intra-epithelial neoplasia (dVIN) at resection margin in early stage human papillomavirus-independent vulvar squamous cell carcinoma

Emily F. Thompson et al.

Summary: In patients with HPV-independent p53 abnormal vulvar squamous cell carcinoma, the presence of differentiated vulvar intra-epithelial neoplasia (dVIN) or abnormal p53 immunohistochemistry on resection margins is associated with increased disease recurrence, regardless of the distance of the invasive margins.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2022)

Article Pathology

Molecular characterization of invasive and in situ squamous neoplasia of the vulva and implications for morphologic diagnosis and outcome

Basile Tessier-Cloutier et al.

Summary: HPV-independent vulvar squamous cell carcinoma is an aggressive clinical entity with ambiguous diagnostic guidelines for premalignant lesions and unclear molecular profile and progression events. Based on the study results, testing for p53 is recommended in all HPV-independent lesions suspicious for dVIN, particularly in the presence of marked inflammation or non-acanthotic skin.

MODERN PATHOLOGY (2021)

Article Cell Biology

Comparison of p53 immunohistochemical staining in differentiated vulvar intraepithelial neoplasia (dVIN) with that in inflammatory dermatoses and benign squamous lesions in the vulva

Y. Ariel Liu et al.

Summary: Strong and uniform p53 staining in basal cells, extending into the parabasal layers, and complete absence of staining (null type) is helpful in distinguishing dVIN from other mimics in the vulva. p53 staining of lesser intensity or quantity, particularly basal overexpression only, overlaps with that in vulvar inflammatory lesions.

HISTOPATHOLOGY (2021)

Article Medical Laboratory Technology

Putative precancerous lesions of vulvar squamous cell carcinoma

Taylor M. Jenkins et al.

Summary: The precursor lesions of vulvar squamous cell carcinoma (VSCC) can be divided into two major groups: HPV-associated and HPV-independent VSCC, with mutations in TP53 being a driving factor in the development of the latter. Less common precursor lesions include DEVIL and VAAD, while inflammatory conditions like lichen sclerosus also pose a risk for VSCC development.

SEMINARS IN DIAGNOSTIC PATHOLOGY (2021)

Article Obstetrics & Gynecology

p53 and p16 expression profiles in vulvar cancer: a translational analysis by the Arbeitsgemeinschaft Gynakologische Onkologie Chemo and Radiotherapy in Epithelial Vulvar Cancer study group

Linn Woelber et al.

Summary: This study aimed to investigate the role of human papillomavirus and p53 status in vulvar squamous cell carcinoma. It found that p16 overexpression is associated with improved prognosis, while p53 positivity is linked to adverse outcomes. A clinically relevant third subgroup of vulvar squamous cell carcinoma with a p53-/p16- phenotype showing an intermediate prognosis was identified and needs further characterization.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

Article Multidisciplinary Sciences

Four-decade trends in lymph node status of patients with vulvar squamous cell carcinoma in northern Italy

Mario Preti et al.

Summary: The study investigated the trends in lymph node status of VSCC patients over four decades in a province of northern Italy, finding a stagnation in lymph node involvement and positive nodes. This suggests a need for a serious reconsideration of the local model for VSCC care.

SCIENTIFIC REPORTS (2021)

Article Cell Biology

DEVIL, VAAD and vLSC constitute a spectrum of HPV-independent, p53-independent intra-epithelial neoplasia of the vulva

Simon F. Roy et al.

Summary: Our study of HPV and p53 independent non-invasive verruciform lesions of the vulva highlights significant clinical, histopathological and biological overlap between VAAD, DEVIL and vLSC, suggesting that these pre-invasive lesions should be viewed as a spectrum. We also show that stromal features such as oedema might play an important role in progression to invasion.

HISTOPATHOLOGY (2021)

Article Obstetrics & Gynecology

Diagnostic Criteria for Differentiated Vulvar Intraepithelial Neoplasia and Vulvar Aberrant Maturation

Debra S. Heller et al.

Summary: Diagnosis of differentiated vulvar intraepithelial neoplasia (dVIN) and vulvar aberrant maturation (VAM) requires collaboration between clinicians and pathologists experienced in vulvar disorders, and close surveillance along with use of these recommendations can assist in prevention of HPV-independent squamous cell carcinoma.

JOURNAL OF LOWER GENITAL TRACT DISEASE (2021)

Review Oncology

Precursor lesions of vulvar squamous cell carcinoma - histology and biomarkers: A systematic review

Shatavisha Dasgupta et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2020)

Article Oncology

Role of human papillomavirus infection in the etiology of vulvar cancer in Italian women

Mario Preti et al.

INFECTIOUS AGENTS AND CANCER (2020)

Article Pathology

HPV-independent Precursors Mimicking High-grade Squamous Intraepithelial Lesions (HSIL) of the Vulva

Natalia Rakislova et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2020)

Article Biochemistry & Molecular Biology

HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers

Shuling Ren et al.

ONCOGENE (2020)

Article Multidisciplinary Sciences

Immunity to commensal papillomaviruses protects against skin cancer

John D. Strickley et al.

NATURE (2019)

Article Multidisciplinary Sciences

Beta and gamma human papillomaviruses in anal and genital sites among men: prevalence and determinants

Vitaly Smelov et al.

SCIENTIFIC REPORTS (2018)

Review Virology

The biology of beta human papillomaviruses

Massimo Tommasino

VIRUS RESEARCH (2017)

Article Dermatology

Role of human papillomavirus in cutaneous squamous cell carcinoma: A meta-analysis

Jennifer Wang et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2014)

Article Multidisciplinary Sciences

Comprehensive molecular characterization of urothelial bladder carcinoma

John N. Weinstein et al.

NATURE (2014)

Review Medicine, General & Internal

Cutaneous HPV and skin cancer

Rosita Accardi et al.

PRESSE MEDICALE (2014)

Article Biochemical Research Methods

Quantification of beta-human papillomavirus DNA by real-time PCR

Soenke J. Weissenborn et al.

NATURE PROTOCOLS (2010)

Article Dermatology

High β-HPV DNA Loads and Strong Seroreactivity Are Present in Epidermodysplasia Verruciformis

Valentina Dell'Oste et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)

News Item Oncology

A review of human carcinogens-Part B: biological agents

Veronique Bouvard et al.

LANCET ONCOLOGY (2009)

Article Biotechnology & Applied Microbiology

Four novel human betapapillomaviruses of species 2 preferentially found in actinic keratosis

Natasa Vasiljevic et al.

JOURNAL OF GENERAL VIROLOGY (2008)

Article Dermatology

Human papillomavirus-DNA loads in actinic keratoses exceed those in non-melanoma skin cancers

SJ Weissenborn et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2005)

Article Oncology

Carcinogenicity of human papillomaviruses

V Cogliano et al.

LANCET ONCOLOGY (2005)

Article Pathology

Vulvar acanthosis with altered differentiation - A precursor to verrucous carcinoma?

AF Nascimento et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2004)