Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 22, Issue 7, Pages 972-974Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458516636836
Keywords
Susac's syndrome; contrast-enhanced FLAIR; leptomeningeal pathology
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Background: Contrast-enhanced (ce) fluid-attenuated inversion recovery magnetic resonance imaging (FLAIR MRI) has recently been shown to identify leptomeningeal pathology in multiple sclerosis. Objective: To demonstrate leptomeningeal enhancement on three-dimensional (3D) FLAIR in a case of Susac's syndrome. Methods: Leptomeningeal enhancement was correlated with clinical activity over 20 months and compared to retinal fluorescein angiography. Results: The size, number, and location of leptomeningeal enhancement varied over time and generally correlated with symptom severity. The appearance was remarkably similar to that of retinal vasculopathy. Conclusion: Ce 3D FLAIR may aid in diagnosis and understanding of pathophysiology in Susac's syndrome and may serve as a biomarker for disease activity.
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