Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 23, Issue 7, Pages 1025-1030Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458516662726
Keywords
Multiple sclerosis; lesion distribution; T(H)1; T(H)17; innate lymphoid cell; lymphoid tissue inducer
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Funding
- Collaborative Research Centre CRC [TR128]
- CRC1009 breaking barriers
- Stiftung Neuromedizin
- Krankheitsbezogene Kompetenznetz Multiple Sklerose (Disease Related Competence Network for Multiple Sclerosis) - Federal Ministry of Education and Research [FKZ 01GI0907]
- German Research Foundation (DFG) [GR3946/2-1]
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Background: Distinct lesion topography in relapsing-remitting multiple sclerosis (RRMS) might be due to different antigen presentation and/or trafficking routes of immune cells into the central nervous system (CNS). Objective: To investigate whether distinct lesion patterns in multiple sclerosis (MS) might be associated with a predominance of distinct circulating T-helper cell subset as well as their innate counterparts. Methods: Flow cytometric analysis of lymphocytes derived from the peripheral blood of patients with exclusively cerebral (n = 20) or predominantly spinal (n = 12) disease manifestation. Results: Patients with exclusively cerebral or preferential spinal lesion manifestation were associated with increased proportions of circulating granulocyte-macrophage colony-stimulating factor (GM-CSF) producing T(H)1 cells or interleukin (IL)-17-producing T(H)17 cells, respectively. In contrast, proportions of peripheral IL-17/IL-22-producing lymphoid tissue inducer (LTi), the innate counterpart of T(H)17 cells, were enhanced in RRMS patients with exclusively cerebral lesion topography. Conclusions: Distinct T-helper and T-helper-like innate lymphoid cell (ILC) subsets are associated with different lesion topography in RRMS.
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