Interaction between ozone and paternal smoking on fetal congenital heart defects among pregnant women at high risk: a multicenter maternal-fetal medicine study

Article Engineering, Environmental

Associations between congenital heart disease and air pollutants at different gestational weeks: a time-series analysis

Wenling Zhang et al.

Summary: Exposure to air pollution during pregnancy is associated with congenital heart disease, with a stronger impact on baby girls.

ENVIRONMENTAL GEOCHEMISTRY AND HEALTH (2023)

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Article Cardiac & Cardiovascular Systems

Maternal Exposure to PM2.5 and the Risk of Congenital Heart Defects in 1.4 Million Births: A Nationwide Surveillance-Based Study

Xuelian Yuan et al.

Summary: This study investigated the association between maternal exposure to fine particulate matter (PM2.5) and fetal congenital heart defects (CHDs) in China. The results showed that higher maternal PM2.5 exposure, especially during the preconception period, increased the risk of certain types of CHDs in offspring. The findings highlight the importance of improving air quality in China and other highly polluted regions for CHD prevention.

CIRCULATION (2023)

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Editorial Material Environmental Sciences

Invited Perspective: Air Pollution and Congenital Heart Defects (CHDs)- a Summary of Two Decades and Future Direction in Research

Keren Agay-Shay

ENVIRONMENTAL HEALTH PERSPECTIVES (2023)

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Article Environmental Sciences

Association between First Trimester Exposure to Ambient PM2.5 and NO2 and Congenital Heart Defects: A Population-Based Cohort Study of 1,342,198 Live Births in Canada

Stephane Buteau et al.

Summary: A retrospective cohort study in Quebec, Canada found that first trimester exposure to ambient fine particulate matter (PM2.5) and nitrogen dioxide (NO2) was associated with an increased risk of congenital heart defects, especially atrial septal defects.

ENVIRONMENTAL HEALTH PERSPECTIVES (2023)

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Article Cardiac & Cardiovascular Systems

Ozone pollution and hospital admissions for cardiovascular events

Yunxing Jiang et al.

Summary: This study examined the potential acute effects of exposure to ambient ozone pollution on hospital admissions of cardiovascular events in China. The results showed that high ambient ozone concentrations were associated with increased hospital admission risk for cardiovascular events, including coronary heart disease, angina pectoris, acute myocardial infarction, acute coronary syndrome, heart failure, stroke, and ischemic stroke. These findings provide evidence for the harmful cardiovascular effects of ambient ozone pollution and highlight the need for control measures.

EUROPEAN HEART JOURNAL (2023)

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Article Health Care Sciences & Services

Inpatient costs of congenital heart surgery in China: results from the National Centre for Cardiovascular Diseases

Qiyu He et al.

Summary: This study explores the inpatient costs of congenital heart surgery in China and reveals the significant economic burden it imposes on families and society. It also identifies an upward trend in costs from 2018 to 2020 and highlights the neonatal group as the most challenging.

LANCET REGIONAL HEALTH-WESTERN PACIFIC (2023)

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Review Environmental Sciences

The association between maternal air pollution exposure and the incidence of congenital heart diseases in children: A systematic review and meta-analysis

Xiaoyu Wan et al.

Summary: Previous studies on the association between maternal exposure to ambient air pollution and congenital anomalies in newborns have yielded ambiguous results. To address this knowledge gap, a systematic review and meta-analysis of existing literature were conducted. Our findings highlight potential evidence for the association between maternal air pollution exposure and congenital heart diseases.

SCIENCE OF THE TOTAL ENVIRONMENT (2023)

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Article Pediatrics

Improving long-term care and outcomes of congenital heart disease: fulfilling the promise of a healthy life

Zhanhao Su et al.

Lancet Child & Adolescent Health (2023)

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Article Pediatrics

Current status and challenges in prenatal and neonatal screening, diagnosis, and management of congenital heart disease in China

Yingying Zhang et al.

Summary: In this series of papers, the burden of congenital heart disease (CHD) in China is described, along with the development of screening, diagnosis, treatment, and follow-up strategies, and the associated challenges. Solutions and recommendations are proposed to improve the outcomes of CHD. Despite progress in prenatal and neonatal screening, diagnosis, and management of CHD in China, challenges remain such as insufficient diagnostic capabilities and unqualified consultation services in some regions and rural areas.

LANCET CHILD & ADOLESCENT HEALTH (2023)

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Article Environmental Sciences

Maternal exposure to air pollution and congenital heart diseases in Henan, China: A register-based case-control study

Huanhuan Zhang et al.

Summary: In Henan, China, exposure to CO in the first and second trimester was associated with an increased risk of overall CHDs. Additionally, NO2 and CO in the first trimester, PM2.5 and PM10 in the second trimester were linked to a higher risk of ASD, with susceptible windows occurring mainly in the 1st-6th gestational weeks. No positive association was found between air pollution and tetralogy of Fallot.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

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Article Engineering, Environmental

Tracking PM2.5 and O3 Pollution and the Related Health Burden in China 2013-2020

Qingyang Xiao et al.

Summary: Based on exposure data sets, this study investigated the spatiotemporal variations in PM2.5 and O3 exposures during 2013-2020, finding a decrease in national PM2.5 exposure but worsened O3 pollution. The improved air quality led to a reduction in premature deaths related to both long- and short-term exposures compared to 2013, with a greater reduction in long-term exposure-related deaths observed in 2017-2020 due to the nonlinear exposure-response curve. Efforts are needed for coordinated control of PM2.5 and O3 for future air quality improvements.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022)

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Article Public, Environmental & Occupational Health

The China birth cohort study (CBCS)

Wentao Yue et al.

Summary: The China Birth Cohort Study is a national study aiming to investigate risk factors for birth defects and develop strategies for their reduction. The study has completed two phases of recruitment and has collected biological samples from participants. The study aims to recruit 500,000 participants by December 2021.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2022)

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Article Multidisciplinary Sciences

Evaluation of IMERG and ERA5 precipitation products over the Mongolian Plateau

Ying Xin et al.

Summary: This study evaluated the performance of precipitation datasets over the Mongolian Plateau and found that they can broadly capture seasonal precipitation cycles and spatial patterns. However, there are still some deficiencies, such as overestimating weak precipitation and underestimating high-intensity precipitation. Among the datasets, ERA5-Land performed the best in describing daily precipitation. In addition, IMERG showed poor detection capabilities in forests due to topographic complexity.

SCIENTIFIC REPORTS (2022)

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Article Medicine, General & Internal

Global, regional, and national time trends in mortality for congenital heart disease, 1990-2019: An age-period-cohort analysis for the Global Burden of Disease 2019 study

Zhanhao Su et al.

Summary: Congenital heart disease (CHD) is the leading cause of morbidity and mortality from birth defects worldwide. The global CHD mortality has decreased over the past 30 years, but there are still many countries with unfavorable period and cohort effects.

ECLINICALMEDICINE (2022)

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Article Obstetrics & Gynecology

Comparison of fetal echocardiogram with fetal cardiac autopsy findings in fetuses with congenital heart disease

Shuang Gao et al.

Summary: The study found that fetal echocardiographic diagnoses were mostly consistent with autopsy findings, with discrepancies mainly consisting of rare cases and minor abnormalities missed or misdiagnosed by FE.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2021)

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Review Environmental Sciences

Association between gestational exposure and risk of congenital heart disease: A systematic review and meta-analysis

Zhao Ma et al.

Summary: The study found that, except for CO and SO2, the association between air pollutants and congenital heart disease was not significant. In subtype analysis, a positive association between air pollutants and ventricular septal defect (VSD) was identified, while a negative association with atrial septal defect (ASD) was observed. The source of heterogeneity in the study mainly came from study area and exposure time.

ENVIRONMENTAL RESEARCH (2021)

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Article Environmental Sciences

Association between maternal exposure to gaseous pollutants and atrial septal defect in China: A nationwide population-based study

Fangyuan Yan et al.

Summary: The study found significant positive associations between maternal exposures to NO2, O3, SO2, and CO and ASD, with varying susceptibility time windows. There was no statistically significant association between PM2.5, PM2.5-10 exposure and ASD risk.

ENVIRONMENTAL RESEARCH (2021)

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Article Reproductive Biology

Independent and interactive effects of air pollutants and ambient heat exposure on congenital heart defects

Wen Jiang et al.

Summary: Studies have found that maternal exposure to sulfur dioxide, carbon monoxide, nitrogen dioxide, PM2.5, and ozone during early pregnancy increases the risk of congenital heart defects, and ambient heat exposure may enhance these effects. Air pollutants showed more apparent synergistic effects under less and moderately intense heat exposure.

REPRODUCTIVE TOXICOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Noninherited Factors in Fetal Congenital Heart Diseases Based on Bayesian Network: A Large Multicenter Study

Yanping Ruan et al.

Summary: This study used a Bayesian network to analyze factors associated with fetal congenital heart diseases (CHDs) and identified six factors directly linked to fetal CHD. The more of these factors present, the higher the risk of CHD, emphasizing the importance of healthcare and prenatal counseling for women with these risk factors.

CONGENITAL HEART DISEASE (2021)

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Review Cardiac & Cardiovascular Systems

Parental smoking and the risk of congenital heart defects in offspring: An updated meta-analysis of observational studies

Lijuan Zhao et al.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2020)

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Article Environmental Sciences

The impact of ambient ozone pollution on pneumonia: A nationwide time-series analysis

Yaohua Tian et al.

ENVIRONMENT INTERNATIONAL (2020)

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Article Medicine, General & Internal

Short term association between ozone and mortality: global two stage time series study in 406 locations in 20 countries

Ana M. Vicedo-Cabrera et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Article Obstetrics & Gynecology

Association between preconception paternal smoking and birth defects in offspring: evidence from the database of the National Free Preconception Health Examination Project in China

Q. Zhou et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2020)

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Article Environmental Sciences

Maternal air pollution exposure associated with risk of congenital heart defect in pre-pregnancy overweighted women

Yin Yang et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

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Review Environmental Sciences

Maternal air pollution exposure and congenital heart defects in offspring: A systematic review and meta-analysis

Cheng-Yang Hu et al.

CHEMOSPHERE (2020)

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Review Public, Environmental & Occupational Health

Birth prevalence of congenital heart disease in China, 1980-2019: a systematic review and meta-analysis of 617 studies

Lijuan Zhao et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

The non-genetic paternal factors for congenital heart defects: A systematic review and meta-analysis

Jiayu Peng et al.

CLINICAL CARDIOLOGY (2019)

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Article Environmental Sciences

Spatial variations in ambient ultrafine particle concentrations and risk of congenital heart defects

Eric Lavigne et al.

ENVIRONMENT INTERNATIONAL (2019)

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Article Environmental Sciences

Synergistic effects of prenatal exposure to fine particulate matter (PM2.5) and ozone (O3) on the risk of preterm birth: A population-based cohort study

Nazeeba Siddika et al.

ENVIRONMENTAL RESEARCH (2019)

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Review Immunology

Ozone Pollution: A Major Health Hazard Worldwide

Junfeng (Jim) Zhang et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Multidisciplinary Sciences

Anthropogenic drivers of 2013-2017 trends in summer surface ozone in China

Ke Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Multidisciplinary Sciences

Impact of household air pollution on human health: source identification and systematic management approach

Fahad Ahmed et al.

SN APPLIED SCIENCES (2019)

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Review Obstetrics & Gynecology

The effect of paternal factors on perinatal and paediatric outcomes: a systematic review and meta-analysis

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HUMAN REPRODUCTION UPDATE (2018)

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Article Environmental Sciences

Interactions between cigarette smoking and ambient PM2.5 for cardiovascular mortality

Michelle C. Turner et al.

ENVIRONMENTAL RESEARCH (2017)

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Article Multidisciplinary Sciences

Chemical exposure-response relationship between air pollutants and reactive oxygen species in the human respiratory tract

Pascale S. J. Lakey et al.

SCIENTIFIC REPORTS (2016)

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Article Statistics & Probability

mice: Multivariate Imputation by Chained Equations inR

Stef van Buuren et al.

Journal of Statistical Software (2015)

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Article Cardiac & Cardiovascular Systems

Diagnosis and Treatment of Fetal Cardiac Disease A Scientific Statement From the American Heart Association

Mary T. Donofrio et al.

CIRCULATION (2014)

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Article Acoustics

ISUOG Practice Guidelines (updated): sonographic screening examination of the fetal heart

J. S. Carvalho et al.

ULTRASOUND IN OBSTETRICS & GYNECOLOGY (2013)

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Article Genetics & Heredity

Population-based evaluation of a suggested anatomic and clinical classification of congenital heart defects based on the International Paediatric and Congenital Cardiac Code

Lucile Houyel et al.

ORPHANET JOURNAL OF RARE DISEASES (2011)

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Article Pharmacology & Pharmacy

Smoking and Congenital Heart Disease: The Epidemiological and Biological Link

Emilio Antonio Luca Gianicolo et al.

CURRENT PHARMACEUTICAL DESIGN (2010)

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Statistics Notes - Interaction revisited: the difference between two estimates

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BMJ-BRITISH MEDICAL JOURNAL (2003)

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Interaction between ozone and paternal smoking on fetal congenital heart defects among pregnant women at high risk: a multicenter maternal-fetal medicine study

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