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Serum resistin and the risk for hepatocellular carcinoma in diabetic patients

Journal

WORLD JOURNAL OF GASTROENTEROLOGY
Volume 29, Issue 27, Pages 4271-4288

Publisher

BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v29.i27.4271

Keywords

Hepatocellular carcinoma; Resistin; Insulin resistance; Obesity; Diabetes; Liver cancer

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Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide. Diabetes has been identified as a significant risk factor for HCC, with resistin hormone playing a potential role in its development and progression. Increased levels of resistin in HCC patients may be associated with more advanced disease stages and poorer prognoses.
Hepatocellular carcinoma (HCC), the predominant type of liver cancer, is a major contributor to cancer-related fatalities across the globe. Diabetes has been identified as a significant risk factor for HCC, with recent research indicating that the hormone resistin could be involved in the onset and advancement of HCC in diabetic individuals. Resistin is a hormone that is known to be involved in inflammation and insulin resistance. Patients with HCC have been observed to exhibit increased resistin levels, which could be correlated with more severe disease stages and unfavourable prognoses. Nevertheless, the exact processes through which resistin influences the development and progression of HCC in diabetic patients remain unclear. This article aims to examine the existing literature on the possible use of resistin levels as a biomarker for HCC development and monitoring. Furthermore, it reviews the possible pathways of HCC initiation due to elevated resistin and offers new perspectives on comprehending the fundamental mechanisms of HCC in diabetic patients. Gaining a better understanding of these processes may yield valuable insights into HCC's development and progression, as well as identify possible avenues for prevention and therapy.

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