4.4 Article

Innate immune responses reverse HIV cognitive disease in mice: Profile by RNAseq in the brain

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

CCL2 is required for initiation but not persistence of HIV infection mediated neurocognitive disease in mice

Boe-Hyun Kim et al.

Summary: Despite antiretroviral therapy, HIV enters the brain shortly after infection and causes neurocognitive impairment in up to 50% of infected individuals. The role of CCL2 in established NCI has been explored, and it has been found that blocking CCL2 transcription can prevent brain infection and NCI.

SCIENTIFIC REPORTS (2023)

Article Medicine, General & Internal

Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection

Mariela P. Cabral-Piccin et al.

Summary: HIV-2 primes CD8+ T cells with potent antiviral functionality by activating the cGAS/STING pathway, resulting in enhanced immune control of HIV-1. The use of cGAMP or other STING agonists can enhance CD8+ T cell-mediated immune responses against HIV-1, providing a new direction for HIV-1 therapy.

EBIOMEDICINE (2023)

Article Immunology

Buprenorphine reverses neurocognitive impairment in EcoHIV infected mice: A potential therapy for HIV-NCI

Aniella J. Murphy et al.

Summary: Thirty-eight million people worldwide are living with HIV, a major public health problem. Antiretroviral therapy revolutionized HIV treatment and significantly increased the lifespan of people with HIV. However, 15-50% of people with HIV develop HIV associated neurocognitive disorders, which negatively impact quality of life. Many people with HIV also have opioid use disorder, and studies suggest that opioid use disorder can contribute to HIV neurocognitive disorders. The effects of buprenorphine, a synthetic opioid agonist used to treat opioid use disorder, on HIV neurocognitive disorders are unclear. This study found that buprenorphine treatment can reverse chronic neurocognitive impairment in mice with HIV infection.

FRONTIERS IN IMMUNOLOGY (2022)

Article Cell Biology

Treatment with buprenorphine prior to EcoHIV infection of mice prevents the development of neurocognitive impairment

Matias Jaureguiberry-Bravo et al.

Summary: Research suggests that the use of buprenorphine in HIV-infected individuals may help alleviate the development of neurocognitive impairment, while also reducing the accumulation of monocytes in the brain.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

Review Biochemistry & Molecular Biology

From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections

Mahesh Chemudupati et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)

Article Multidisciplinary Sciences

Targeting the HIV-infected brain to improve ischemic stroke outcome

Luc Bertrand et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys

Erica N. Borducchi et al.

NATURE (2018)

Article Biochemical Research Methods

Reactome pathway analysis: a high-performance in-memory approach

Antonio Fabregat et al.

BMC BIOINFORMATICS (2017)

Review Clinical Neurology

HIV-associated neurocognitive disorder - pathogenesis and prospects for treatment

Deanna Saylor et al.

NATURE REVIEWS NEUROLOGY (2016)

Article Biochemistry & Molecular Biology

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

Maxim V. Kuleshov et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Biochemistry & Molecular Biology

Heatmapper: web-enabled heat mapping for all

Sasha Babicki et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Multidisciplinary Sciences

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef

Yoshiko Usami et al.

NATURE (2015)

Article Immunology

Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B

Inna S. Afonina et al.

IMMUNOLOGICAL REVIEWS (2015)

Article Immunology

CD8+ T Cells Maintain Suppression of Simian Immunodeficiency Virus in the Central Nervous System

Maria Cecilia G. Marcondes et al.

JOURNAL OF INFECTIOUS DISEASES (2015)

Review Pharmacology & Pharmacy

Behavioral assays with mouse models of Alzheimer's disease: Practical considerations and guidelines

Daniela Puzzo et al.

BIOCHEMICAL PHARMACOLOGY (2014)

Article Clinical Neurology

Enhanced Human Immunodeficiency Virus Type 1 Expression and Neuropathogenesis in Knockout Mice Lacking Type I Interferon Responses

Hongxia He et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Biochemical Research Methods

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

Edward Y. Chen et al.

BMC BIOINFORMATICS (2013)

Article Multidisciplinary Sciences

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

Caroline Goujon et al.

NATURE (2013)

Article Multidisciplinary Sciences

Phenotypic properties of transmitted founder HIV-1

Nicholas F. Parrish et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Virology

Relative resistance of HIV-1 founder viruses to control by interferon-alpha

Angharad E. Fenton-May et al.

RETROVIROLOGY (2013)

Article Neurosciences

Mice Chronically Infected with Chimeric HIV Resist Peripheral and Brain Superinfection: A Model of Protective Immunity to HIV

Jennifer L. Kelschenbach et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2012)

Review Neurosciences

Translating the Brain Transcriptome in NeuroAIDS: From Non-human Primates to Humans

Jessica M. Winkler et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

Mice, men and the relatives: cross-species studies underpin innate immunity

Clare E. Bryant et al.

OPEN BIOLOGY (2012)

Review Biochemistry & Molecular Biology

Molecular Mechanisms of Fear Learning and Memory

Joshua P. Johansen et al.

Review Medicine, Research & Experimental

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

Mark L. Hanke et al.

CLINICAL SCIENCE (2011)

Review Immunology

The Drosophila Toll Signaling Pathway

Susanna Valanne et al.

JOURNAL OF IMMUNOLOGY (2011)

Review Biology

APOBEC proteins and intrinsic resistance to HIV-1 infection

Michael H. Malim

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2009)

Article Multidisciplinary Sciences

A mouse model for study of systemic HIV-1 infection, antiviral immune responses, and neuroinvasiveness

MJ Potash et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Immunology

Acquired neuronal channelopathies in HIV-associated dementia

BB Gelman et al.

JOURNAL OF NEUROIMMUNOLOGY (2004)

Review Cell Biology

The emotional brain, fear, and the amygdala

J LeDoux

CELLULAR AND MOLECULAR NEUROBIOLOGY (2003)

Review Immunology

Granzyme B: a natural born killer

SJ Lord et al.

IMMUNOLOGICAL REVIEWS (2003)

Review Genetics & Heredity

The evolution and genetics of innate immunity

DA Kimbrell et al.

NATURE REVIEWS GENETICS (2001)