Journal
VETERINARY PATHOLOGY
Volume -, Issue -, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/03009858231204253
Keywords
horse; immune-mediated myositis; myosin heavy chain 1; myosin heavy-chain myopathy; MYH1; Streptococcus equi subsp. equi; Actinobacillus equuli
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Two horses presented with similar polyphasic histiocytic and lymphoplasmacytic myositis with necrosis, mineralization, and regeneration. Case 1 also had suppurative retropharyngeal lymphadenitis and renal purpura hemorrhagica. Case 2 had a pulmonary abscess caused by Actinobacillus equuli.
A 1.5-year-old American quarter horse gelding (case 1) and an 11-month-old American quarter horse filly (case 2) were presented for acute onset pelvic lameness and lethargy. Case 1 had nasal discharge, while case 2 developed rapid muscle atrophy. Both horses had elevated serum creatine kinase activity. The horses showed similar polyphasic histiocytic and lymphoplasmacytic myositis with necrosis, mineralization, and regeneration. Additionally, case 1 had Streptococcus equi subsp. equi-induced suppurative retropharyngeal lymphadenitis with renal purpura hemorrhagica and myoglobinuric nephropathy. A focal pulmonary abscess caused by Actinobacillus equuli was found in case 2. Genetic testing revealed case 1 as heterozygous and case 2 as homozygous for the E321G MYH1 variant, supporting the diagnosis of myosin heavy-chain myopathy, with concomitant bacterial disease as potential triggers.
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