4.2 Article

Cognitive Changes Associated with Aging and Physical Disease in Dogs and Cats

Related references

Note: Only part of the references are listed.
Article Veterinary Sciences

2023 AAHA Senior Care Guidelines for Dogs and Cats

Ravinder Dhaliwal et al.

Summary: Veterinary professionals need to educate clients that old age is not a disease and provide medical care and support to senior pets. Evidence-guided medicine and proper client education can enhance the quality of life for senior pets and their families.

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION (2023)

Article Geriatrics & Gerontology

Associations between physical activity and cognitive dysfunction in older companion dogs: results from the Dog Aging Project

Emily E. Bray et al.

Summary: This study explores the association between physical activity and cognitive health in companion dogs. The research findings indicate that higher levels of physical activity are associated with lower severity of cognitive dysfunction symptoms, less symptom worsening, and lower prevalence of canine cognitive dysfunction. This highlights the value of companion dogs as a model for studying the relationship between physical activity and cognitive aging.

GEROSCIENCE (2023)

Article Multidisciplinary Sciences

Age, breed, sex and diet influence serum metabolite profiles of 2000 pet dogs

Jenni Puurunen et al.

Summary: Metabolomics has vast potential in biomedical applications. Factors such as age, breed, sex, sterilization, diet type, and fasting time significantly affect the metabolite profiles of healthy pet dogs, with breed and age causing considerable variation in metabolite concentrations.

ROYAL SOCIETY OPEN SCIENCE (2022)

Article Veterinary Sciences

Aging in Cats: Owner Observations and Clinical Finding in 206 Mature Cats at Enrolment to the Cat Prospective Aging and Welfare Study

Nathalie Dowgray et al.

Summary: This study investigated aging and welfare in 206 cats from the North-west of the UK and found that a significant proportion of mature cats experience physical and behavioral changes, as well as common age-related conditions. Thorough clinical assessments are important in identifying these abnormalities in mature pet cats visiting primary care practice.

FRONTIERS IN VETERINARY SCIENCE (2022)

Article Veterinary Sciences

Electroencephalographic signatures of dogs with presumptive diagnosis of canine cognitive dysfunction

Alejandra Mondino et al.

Summary: Canine Cognitive Dysfunction (CCD) is a neurodegenerative disease similar to early Alzheimer's disease in dogs. This study found that quantitative EEG analysis can help diagnose CCD and demonstrate its relevance as a translational model for early AD.

RESEARCH IN VETERINARY SCIENCE (2022)

Article Veterinary Sciences

Relationship between hearing, cognitive function, and quality of life in aging companion dogs

Gilad Fefer et al.

Summary: Presbycusis in aging companion dogs negatively affects cognitive function, quality of life, and hearing loss. It is associated with poor executive performance and owner-assessed dementia severity.

JOURNAL OF VETERINARY INTERNAL MEDICINE (2022)

Article Veterinary Sciences

Morbidity and mortality in elderly dogs - a model for human aging

Patricia Dias-Pereira

Summary: This study assessed age-related diseases and mortality in a population of 269 elderly canines, and found similarities with human patterns, such as cancer and cardiovascular diseases being major causes of illness and death. These findings further highlight the potential of domestic dogs as suitable animal models for translational research in gerontology.

BMC VETERINARY RESEARCH (2022)

Article Multidisciplinary Sciences

Evaluation of cognitive function in the Dog Aging Project: associations with baseline canine characteristics

Sarah Yarborough et al.

Summary: This study utilized a previously developed rating scale to investigate the prevalence of canine cognitive dysfunction (CCD) in a large cohort of companion dogs. Various factors such as age, activity level, health status, and medical history were found to be associated with CCD. Additionally, weight-based lifespan quartile estimation was suggested as a useful tool for CCD screening by veterinarians.

SCIENTIFIC REPORTS (2022)

Article Behavioral Sciences

The scholar's best friend: research trends in dog cognitive and behavioral studies

Massimo Aria et al.

Summary: This study analyzed the publication trend of articles on dog cognition and behavior over the past 34 years, revealing a significant increase in scientific publications on dogs since 2005. An in-depth bibliometric analysis was conducted on dog cognitive and behavioral studies, which supported the perception that dogs are attracting more interest from scholars and contributing to interdisciplinary collaborations and future research in the field.

ANIMAL COGNITION (2021)

Article Behavioral Sciences

Medium-chain triglycerides dietary supplement improves cognitive abilities in canine epilepsy

Benjamin Andreas Berk et al.

Summary: The study demonstrates that medium-chain triglyceride dietary supplementation can improve cognitive abilities in dogs with epilepsy, including spatial working memory and problem-solving ability.

EPILEPSY & BEHAVIOR (2021)

Review Veterinary Sciences

Cognitive Dysfunction in Cats: Update on Neuropathological and Behavioural Changes Plus Clinical Management

Lorena Sordo et al.

Summary: Cognitive dysfunction syndrome (CDS) in cats is a confirmed condition that shares similarities with human Alzheimer's disease, resulting in cognitive decline and potential dementia. Cats with CDS exhibit behavioral abnormalities and neuropathologies, making them a potential natural model for human dementia studies.

VETERINARY RECORD (2021)

Article Veterinary Sciences

Novel Diagnostic Tools for Identifying Cognitive Impairment in Dogs: Behavior, Biomarkers, and Pathology

Zuzana Vikartovska et al.

Summary: A comprehensive approach using CADES questionnaire, biochemical analyses and blood serum biomarkers can enable early diagnosis of canine cognitive dysfunction syndrome (CCDS) in senior dogs.

FRONTIERS IN VETERINARY SCIENCE (2021)

Review Pharmacology & Pharmacy

Monoamine Oxidase Inhibitors: A Review of Their Anti-Inflammatory Therapeutic Potential and Mechanisms of Action

Mahyar Ostadkarampour et al.

Summary: Chronic inflammatory diseases have a significant impact on patients' quality of life and financial burden. Monoamine oxidase (MAO) inhibitor drugs have been shown to have anti-inflammatory effects, not only in CNS-associated diseases, but also in various non-CNS tissues. Understanding the mechanism(s) of action of MAO inhibitors is critical for their development as anti-inflammatories.

FRONTIERS IN PHARMACOLOGY (2021)

Article Veterinary Sciences

Effects of a four-week group class created for dogs at least eight years of age on the development and progression of signs of cognitive dysfunction syndrome

Maggie L. O'Brian et al.

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION (2021)

Article Multidisciplinary Sciences

Treatment of canine cognitive dysfunction with novel butyrylcholinesterase inhibitor

Maja Zakosek Pipan et al.

Summary: The study treated aged dogs with CCD using a newly developed BChEi, showing significant improvement in cognitive abilities and quality of life in dogs with moderate cognitive impairment. No significant side effects were observed.

SCIENTIFIC REPORTS (2021)

Article Veterinary Sciences

Periodontal disease is associated with cognitive dysfunction in aging dogs: A blinded prospective comparison of visual periodontal and cognitive questionnaire scores

Curtis Wells Dewey et al.

Summary: A significant association was found between severe periodontal disease and higher cognitive impairment scores in aging dogs. While a cause-and-effect relationship could not be confirmed in this study, a link between periodontal disease and cognitive dysfunction was established that warrants further investigation using more rigorous criteria.

OPEN VETERINARY JOURNAL (2021)

Article Behavioral Sciences

Dog cognitive development: a longitudinal study across the first 2 years of life

Emily E. Bray et al.

Summary: Through testing 160 candidate assistance dogs on a series of cognitive tasks, it was found that cognitive abilities improved with age, especially in areas such as executive function and social gaze. The study results showed that individual differences were both early emerging and enduring, with moderate levels of rank-order stability observed for factors such as social attention to humans, use of human communicative signals, independent problem-solving, odor discrimination, and inhibitory control between the two timepoints.

ANIMAL COGNITION (2021)

Article Behavioral Sciences

Age influences domestic dog cognitive performance independent of average breed lifespan

Marina M. Watowich et al.

ANIMAL COGNITION (2020)

Review Endocrinology & Metabolism

Adrenal Aging and Its Implications on Stress Responsiveness in Humans

Andreas Yiallouris et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Review Endocrinology & Metabolism

The Impact of Aging on Adipose Function and Adipokine Synthesis

Peter Mancuso et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Review Clinical Neurology

Neurofilament light chain as a biomarker in neurological disorders

Lorenzo Gaetani et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

Article Veterinary Sciences

Relation between periodontal disease and systemic diseases in dogs

Jose Diogo Pereira dos Santos et al.

RESEARCH IN VETERINARY SCIENCE (2019)

Article Veterinary Sciences

Behavioural changes in dogs with idiopathic epilepsy

Fraje Watson et al.

VETERINARY RECORD (2019)

Article Behavioral Sciences

Absolute brain size predicts dog breed differences in executive function

Daniel J. Horschler et al.

ANIMAL COGNITION (2019)

Review Agriculture, Dairy & Animal Science

A Review of Medical Conditions and Behavioral Problems in Dogs and Cats

Tomas Camps et al.

ANIMALS (2019)

Article Veterinary Sciences

Pain and adverse behavior in declawed cats

Nicole K. Martell-Moran et al.

JOURNAL OF FELINE MEDICINE AND SURGERY (2018)

Article Multidisciplinary Sciences

Cognitive dysfunction in naturally occurring canine idiopathic epilepsy

Rowena M. A. Packer et al.

PLOS ONE (2018)

Article Veterinary Sciences

Disease burden in four populations of dog and cat breeds compared to mixed-breed dogs and European shorthair cats

S. F. A. Keijser et al.

PREVENTIVE VETERINARY MEDICINE (2017)

Article Multidisciplinary Sciences

Effects of maternal investment, temperament, and cognition on guide dog success

Emily E. Bray et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Engrams and circuits crucial for systems consolidation of a memory

Takashi Kitamura et al.

SCIENCE (2017)

Article Veterinary Sciences

Hematology and biochemistry of agingevidence of anemia of the elderly in old dogs

Lauren B. Radakovich et al.

VETERINARY CLINICAL PATHOLOGY (2017)

Review Biochemistry & Molecular Biology

Vascular cognitive impairment: Modeling a critical neurologic disease in vitro and in vivo

Alex M. Helman et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)

Review Veterinary Sciences

Evaluating aging in cats: How to determine what is healthy and what is disease

Jan Bellows et al.

JOURNAL OF FELINE MEDICINE AND SURGERY (2016)

Article Veterinary Sciences

Pathology and behaviour in feline medicine: investigating the link between vomeronasalitis and aggression

Pietro Asproni et al.

JOURNAL OF FELINE MEDICINE AND SURGERY (2016)

Article Geriatrics & Gerontology

Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine

Shikha Snigdha et al.

NEUROBIOLOGY OF AGING (2016)

Article Agriculture, Dairy & Animal Science

Assessment of severity and progression of canine cognitive dysfunction syndrome using the CAnine DEmentia Scale (CADES)

Aladar Madari et al.

APPLIED ANIMAL BEHAVIOUR SCIENCE (2015)

Article Psychology, Biological

The ontogeny of human point following in dogs: When younger dogs outperform older

Isabela Zaine et al.

BEHAVIOURAL PROCESSES (2015)

Article Veterinary Sciences

Defining healthy aging in older dogs and differentiating healthy aging from disease

Jan Bellows et al.

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION (2015)

Review Neurosciences

Social cognition in schizophrenia

Michael F. Green et al.

NATURE REVIEWS NEUROSCIENCE (2015)

Review Biotechnology & Applied Microbiology

Modulation of Immunity and Inflammation by the Mineralocorticoid Receptor and Aldosterone

N. Munoz-Durango et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Behavioral Sciences

The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition

Sheree F. Logue et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2014)

Review Psychology

Executive Functions

Adele Diamond

ANNUAL REVIEW OF PSYCHOLOGY, VOL 64 (2013)

Article Biochemistry & Molecular Biology

Treatment with Huperzine A Improves Cognition in Vascular Dementia Patients

Zhi-Qiang Xu et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2012)

Article Psychology, Clinical

An exploration of relationships among measures of social cognition, decision making, and emotional intelligence

Claire M. Brabec et al.

JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY (2012)

Article Behavioral Sciences

Gastrointestinal disorders in dogs with excessive licking of surfaces

Veronique Becuwe-Bonnet et al.

JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH (2012)

Article Agriculture, Dairy & Animal Science

The effects of fear and anxiety on health and lifespan in pet dogs

Nancy A. Dreschel

APPLIED ANIMAL BEHAVIOUR SCIENCE (2010)

Article Nutrition & Dietetics

Dietary supplementation with medium-chain TAG has long-lasting cognition-enhancing effects in aged dogs

Yuanlong Pan et al.

BRITISH JOURNAL OF NUTRITION (2010)

Article Agriculture, Dairy & Animal Science

Adipose tissue gene expression profiles of healthy young adult and geriatric dogs

Kelly S. Swanson et al.

ARCHIVES OF ANIMAL NUTRITION (2009)

Article Pathology

Ageing, Immunosenescence and Inflammageing in the Dog and Cat

M.J. Day

JOURNAL OF COMPARATIVE PATHOLOGY (2009)

Review Veterinary Sciences

Neuropathic Pain in Dogs and Cats: If Only They Could Tell Us If They Hurt

Karol A. Mathews

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE (2008)

Article Psychology, Developmental

Inhibitory control and emotion regulation in preschool children

Stephanie M. Carlson et al.

COGNITIVE DEVELOPMENT (2007)

Article Agriculture, Dairy & Animal Science

Canine cognitive dysfunction syndrome: Prevalence, clinical signs and treatment with a neuroprotective nutraceutical

Maria Cristina Osella et al.

APPLIED ANIMAL BEHAVIOUR SCIENCE (2007)

Article Behavioral Sciences

Enhanced spatial ability in aged dogs following dietary and behavioural enrichment

P. M. D. Nippak et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2007)

Article Behavioral Sciences

Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat

K McAlonan et al.

BEHAVIOURAL BRAIN RESEARCH (2003)

Article Multidisciplinary Sciences

Rethinking the lesser brain

J Bower et al.

SCIENTIFIC AMERICAN (2003)

Article Geriatrics & Gerontology

Dietary enrichment counteracts age-associated cognitive dysfunction in canines

NW Milgram et al.

NEUROBIOLOGY OF AGING (2002)

Review Clinical Neurology

The effects of oral selegiline hydrochloride on learning and training in the dog: A psychobiological interpretation

D Mills et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2001)

Article Veterinary Sciences

Prevalence of behavioral changes associated with age-related cognitive impairment in dogs

JC Neilson et al.

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION (2001)

Article Geriatrics & Gerontology

Vascular and parenchymal Aβ deposition in the aging dog:: correlation with behavior

MA Colle et al.

NEUROBIOLOGY OF AGING (2000)

Article Biochemistry & Molecular Biology

Gastrointestinal transit times in young and old cats

SE Peachey et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY (2000)

Article Behavioral Sciences

Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog

B Adams et al.

BEHAVIOURAL BRAIN RESEARCH (2000)