☆ 4.7 Article

Ultrasound-assisted continuous crystallization of metastable polymorphic pharmaceutical in a slug-flow tubular crystallizer

ULTRASONICS SONOCHEMISTRY (2023)

Related references

Note: Only part of the references are listed.

Article Engineering, Chemical

Controlled crystallization of metastable polymorphic pharmaceutical: Comparative study of batchwise and continuous tubular crystallizers

Lan Fang et al.

Summary: This study presents the successful continuous preparation of pure metastable crystal Form III of APZ using ultrasound and slug-assisted tubular crystallizers, providing a solution to the difficulty of reproducibly obtaining metastable polymorphs in traditional batch crystallizers.

CHEMICAL ENGINEERING SCIENCE (2023)

Add to Collection

Article Engineering, Chemical

Ultrasound-Assisted Slug-Flow Tubular Crystallization for Preparation of Fine Ibuprofen Crystals

Mingpu Yuan et al.

Summary: An ultrasonic-assisted tubular crystallization system was developed to prepare ibuprofen crystals with an average particle size of 6.23 µm. The results showed that ultrasound promoted nucleation and reduced crystal aggregation. The high degree of continuous supersaturation and enhanced micromixing were key factors for the formation of ibuprofen fine crystals.

CHEMICAL ENGINEERING & TECHNOLOGY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Preparation, Stabilization, and Dissolution Enhancement of Vortioxetine Hydrobromide Metastable Polymorphs in Silica Nanopores

Yun Cao et al.

Summary: The development of metastable form crystals of active pharmaceutical ingredients can improve the bioavailability of poorly soluble drugs. The study found that the solvent properties and silica pore size affect the polymorphic outcomes. The confined metastable form exhibited enhanced physical stability and a faster dissolution rate compared to the bulk form.

CRYSTAL GROWTH & DESIGN (2022)

Add to Collection

Article Chemistry, Analytical

Application of advanced thermal analysis for characterization of crystalline and amorphous phases of carvedilol

Marcin Skotnicki et al.

Summary: The thermal behavior of crystalline and amorphous carvedilol phases was studied using advanced thermal analysis methods. The study provided important information about the crystalline and amorphous states of carvedilol.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2022)

Add to Collection

Article Engineering, Chemical

Particle design of the metastable form of clopidogrel hydrogen sulfate by building spherulitic growth operating spaces in binary solvent systems

Yanbo Liu et al.

Summary: The study established operating spaces for spherulitic growth by utilizing binary solvent systems of isopropyl acetate + lower alcohol to address limitations in powder properties and stability of form I of clopidogrel hydrogen sulfate. By following the supersaturation-dependent spherulitic growth mechanism, an optimized crystallization process was designed to obtain high-quality spherulites, resulting in improved powder properties compared to the reported single solvent system.

POWDER TECHNOLOGY (2021)

Add to Collection

Article Crystallography

Flow Map for Hydrodynamics and Suspension Behavior in a Continuous Archimedes Tube Crystallizer

Jana Sonnenschein et al.

Summary: The Archimedes Tube Crystallizer (ATC) is a small-scale coiled tubular crystallizer operated with air-segmented flow, overcoming pressure drop limitations of other continuous crystallizers. Understanding continuous crystallizer phenomena is crucial for well-designed crystallization processes, especially for small-scale applications in pharmaceutical and fine chemical industries.

CRYSTALS (2021)

Add to Collection

Article Engineering, Chemical

Theoretical Feedback Control Scheme for the Ultrasound-Assisted Continuous Antisolvent Crystallization of Aspirin in a Tubular Crystallizer

Symeon Savvopoulos et al.

Summary: The article proposes and evaluates a theoretical feedback control scheme for the production of high-quality crystals in a continuous tubular crystallizer, with a focus on trajectory control of crystal size, disturbance alleviation, and worst-case operating scenarios. The developed controller shows promise in maintaining high-quality crystals during antisolvent crystallization of aspirin in water and ethanol under ultrasound.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2021)

Add to Collection

Article Engineering, Chemical

Continuous Crystallization Using Ultrasound Assisted Nucleation, Cubic Cooling Profiles and Oscillatory Flow

Arne Vancleef et al.

Summary: Continuous tubular crystallizers have the potential to reduce manufacturing costs and increase product quality, but designing them can be complex and challenging. This study successfully designed a tubular crystallizer that combines various techniques to address fouling and clogging issues, demonstrating good operational stability and high yields.

PROCESSES (2021)

Add to Collection

Article Chemistry, Applied

Investigation of Wet Milling and Indirect Ultrasound as Means for Controlling Nucleation in the Continuous Crystallization of an Active Pharmaceutical Ingredient

Yihui Yang et al.

Summary: This study compared the use of wet milling and indirect ultrasound in promoting nucleation and controlling particle size during continuous crystallization of an active pharmaceutical ingredient (API). Both methods significantly improved nucleation kinetics, with the wet mill achieving a minimum d(50) of 27 and ultrasound achieving 36.8 μm. The effectiveness of wet milling was demonstrated in a continuous crystallization process of the API, achieving a steady state with minimal fouling and discussing strategies for improving overall robustness in routine manufacturing.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2021)

Add to Collection

Article Crystallography

Ultrasound in Continuous Tubular Crystallizers: Parameters Affecting the Nucleation Rate

Arne Vancleef et al.

Summary: The study on controlling nucleation rate in continuous ultrasonic processes found that ultrasound-assisted nucleation process is presumably dominated by secondary nucleation. Parameters such as supersaturation, residence time, and flow rate also have a strong influence on nucleation rate. Additionally, the influence of ultrasonic power is crucial but levels off once a certain amount is reached.

CRYSTALS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Towards more accurate solubility measurements with real time monitoring: a carvedilol case study

Dora Csicsak et al.

Summary: This study focused on the challenges of solubility measurement and introduced new techniques and detection methods for more accurate results. Investigating the solubility of carvedilol polymorphs revealed the impact of crystal structure, pH, and buffer composition on thermodynamic equilibrium solubility. The study also showed different dissolution kinetics for the polymorphs depending on pH and buffer solution, emphasizing the importance of standardized measurements in solubility studies.

NEW JOURNAL OF CHEMISTRY (2021)

Add to Collection

Review Chemistry, Applied

Recent Progress in Continuous Crystallization of Pharmaceutical Products: Precise Preparation and Control

Yiming Ma et al.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2020)

Add to Collection

Review Engineering, Chemical

Continuous crystallization as a downstream processing step of pharmaceutical proteins: A review

Siyu Pu et al.

CHEMICAL ENGINEERING RESEARCH & DESIGN (2020)

Add to Collection

Article Pharmacology & Pharmacy

Binary polymeric amorphous carvedilol solid dispersions: In vitro and in vivo characterization

Marko Krstic et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

Add to Collection

Article Thermodynamics

Determination and Correlation of Solubility of Carvedilol in Six Pure Solvents and Three Binary Solvent Mixtures at T=278.15-313.15 K

Ru Peng Ou et al.

JOURNAL OF CHEMICAL AND ENGINEERING DATA (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Structural analysis of metastable pharmaceutical loratadine form II, by 3D electron diffraction and DFT plus D energy minimisation

Grahame R. Woollam et al.

CRYSTENGCOMM (2020)

Add to Collection

Article Chemistry, Multidisciplinary

High-throughput on demand access of single enantiomers by a continuous flow crystallization process

Fabio Cameli et al.

CRYSTENGCOMM (2020)

Add to Collection

Article Crystallography

Continuous crystallization of α-form L-glutamic acid in an MSMPR-Tubular crystallizer system

Zhenguo Gao et al.

JOURNAL OF CRYSTAL GROWTH (2019)

Add to Collection

Article Acoustics

The use of ultrasound in the crystallization process of an active pharmaceutical ingredient

Lucija Majal Belca et al.

ULTRASONICS SONOCHEMISTRY (2019)

Add to Collection

Article Acoustics

Enhancing pharmaceutical crystallization in a flow crystallizer with ultrasound: Anti-solvent crystallization

M. N. Hussain et al.

ULTRASONICS SONOCHEMISTRY (2019)

Add to Collection

Review Chemistry, Multidisciplinary

Designs of continuous-flow pharmaceutical crystallizers: developments and practice

Mo Jiang et al.

CRYSTENGCOMM (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Ultrasonic Irradiation and Seeding To Prevent Metastable Liquid-Liquid Phase Separation and Intensify Crystallization

Zhenguo Gao et al.

CRYSTAL GROWTH & DESIGN (2018)

Add to Collection

Review Acoustics

Applications of ultrasound to chiral crystallization, resolution and deracemization

Christos Xiouras et al.

ULTRASONICS SONOCHEMISTRY (2018)

Add to Collection

Article Crystallography

Reducing the Induction Time Using Ultrasound and High-Shear Mixing in a Continuous Crystallization Process

Arne Vancleef et al.

CRYSTALS (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Continuous-Flow Tubular Crystallization To Discriminate between Two Competing Crystal Polymorphs. 2. Antisolvent Crystallization

Bart Rimez et al.

CRYSTAL GROWTH & DESIGN (2018)

Add to Collection

Article Pharmacology & Pharmacy

Vibrational spectroscopic and Hirshfeld surface analysis of carvedilol crystal forms

Livia D. Prado et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Add to Collection

Article Engineering, Chemical

Low-Cost Noninvasive Real-Time Imaging for Tubular Continuous-Flow Crystallization

Mo Jiang et al.

CHEMICAL ENGINEERING & TECHNOLOGY (2018)

Add to Collection

Article Crystallography

Ultrasound Assisted Particle Size Control by Continuous Seed Generation and Batch Growth

Jeroen Jordens et al.

CRYSTALS (2017)

Add to Collection

Review Engineering, Multidisciplinary

Progress of Pharmaceutical Continuous Crystallization

Dejiang Zhang et al.

ENGINEERING (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Crystal Engineering in Continuous Plug-Flow Crystallizers

Maximilian O. Besenhard et al.

CRYSTAL GROWTH & DESIGN (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Continuous Crystallization of Paracetamol (Acetaminophen) Form II: Selective Access to a Metastable Solid Form

Lauren R. Agnew et al.

CRYSTAL GROWTH & DESIGN (2017)

Add to Collection

Article Pharmacology & Pharmacy

Evaluation and correlation of the physicochemical properties of carvedilol

Josyane Marcia Vasconcelos Alves et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2016)

Add to Collection

Article Engineering, Chemical

Design of a Continuous Tubular Cooling Crystallizer for Process Development on Lab-Scale

Lukas Hohmann et al.

CHEMICAL ENGINEERING & TECHNOLOGY (2016)

Add to Collection

Article Energy & Fuels

Continuous crystallization using a sonicated tubular system for controlling particle size in an API manufacturing process

Masashi Furuta et al.

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Crystal Size Control in a Continuous Tubular Crystallizer

Maximilian O. Besenhard et al.

CRYSTAL GROWTH & DESIGN (2015)

Add to Collection

Article Chemistry, Multidisciplinary

An insight into carvedilol solid forms: effect of supramolecular interactions on the dissolution profiles

Livia Deris Prado et al.

CRYSTENGCOMM (2014)

Add to Collection

Article Chemistry, Applied

Continuous Crystallization and Polymorph Dynamics in the L-Glutamic Acid System

Tsai-Ta C. Lai et al.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2014)

Add to Collection

Article Chemistry, Applied

Implementation of Raman Signal Feedback to Perform Controlled Crystallization of Carvedilol

Hajnalka Pataki et al.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2013)

Add to Collection

Article Chemistry, Multidisciplinary

In-Line Monitoring of Carvedilol Crystallization Using Raman Spectroscopy

Hajnalka Pataki et al.

CRYSTAL GROWTH & DESIGN (2012)

Add to Collection

© Peeref 2019-2024. All rights reserved.