Does attenuated plasmodial sporozoite-mediated protection require peroxynitrite?

Attenuated plasmodial sporozoite-induced immune response includes intrahepatic nitric oxide (NO) pro-duction, which promotes apoptosis of infected hepatocytes and consequent parasite clearance. NO in excess reacts with superoxide, forming peroxynitrite, a powerful cytotoxic agent. Here, I suggest that peroxynitrite proapoptotic action may contribute to the attenuated malarial sporozoite-mediated protection.

Automated summary

The pro-apoptotic action of peroxynitrite may contribute to the attenuated protection mediated by malarial sporozoite.