☆ 4.6 Article

The therapeutic potential of natural killer cells in neuropathic pain

TRENDS IN NEUROSCIENCES (2023)

Related references

Note: Only part of the references are listed.

Review Immunology

ILC1: Development, maturation, and transcriptional regulation

Renske L. R. E. Taggenbrock et al.

Summary: This review discusses the recent advances in the development, differentiation, and effector maturation of ILC1s, as well as the observed heterogeneity in ILC1 populations within different tissues. The study of transcriptional programs reveals the shared characteristics between ILC1s and other tissue-resident lymphocytes, aiding in the effective response of ILC1s to tissue-invading pathogens.

EUROPEAN JOURNAL OF IMMUNOLOGY (2023)

Add to Collection

Article Immunology

Brain endothelial CXCL12 attracts protective natural killer cells during ischemic stroke

Shuaiwei Wang et al.

Summary: This study found that ILC family members are restricted in the brain. When the brain experiences ischemic injury, ILCs gather at the edge of the lesion and play a protective role. The study also identified the importance of blood-brain barrier-derived CXCL12 in attracting NK cells to ischemic brain lesions.

JOURNAL OF NEUROINFLAMMATION (2023)

Add to Collection

Article Anatomy & Morphology

Intraneural fibrosis and loss of microvascular architecture-Key findings investigating failed human nerve allografts

Isabel Zucal et al.

Summary: Histological and immunohistochemical analysis of two failed allograft reconstructions indicate that the failure of human allografts may be associated with the loss of physiological microvascular architecture. Further studies are needed to elucidate the complex interplay of angiogenesis, lymphangiogenesis, and axonal regeneration in understanding the mechanisms of human allograft failure.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2022)

Add to Collection

Review Medicine, Research & Experimental

Group 2 innate lymphoid cells (ILC2s) are important in typical type 2 immune-mediated diseases and an essential therapeutic target

Jie Jin et al.

Summary: The prevalence of allergic diseases has increased due to environmental changes. Type 2 immunity, particularly the ILC2-DC-Th2 axis, plays a crucial role in allergic diseases. ILC2s are activated by cytokines and lipid inflammatory mediators and produce a significant amount of type 2 cytokines. Therapeutic development targeting ILC2-derived cytokines is important in treating type 2-mediated diseases.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2022)

Add to Collection

Article Cell Biology

Mice lacking perforin have improved regeneration of the injured femoral nerve

Igor Jakovcevski et al.

Summary: This study found that perforin restricts motor recovery after peripheral nerve injury by decreasing motoneuron survival and reducing myelination. In addition, perforin-deficient mice showed better motor recovery and lower lymphocyte infiltration, indicating its important role in the regeneration process.

NEURAL REGENERATION RESEARCH (2022)

Add to Collection

Article Cell Biology

Robust temporal changes of cellular senescence and proliferation after sciatic nerve injury

Yin-Ying Shen et al.

Summary: Cellular senescence and proliferation are essential for wound healing and tissue remodeling. This study analyzed gene expression patterns in rat sciatic nerve stumps and dorsal root ganglia after injury to reveal the genetic changes associated with cellular senescence and proliferation. The study found that cellular senescence and proliferation were less vigorous in the dorsal root ganglia compared to the sciatic nerve stumps.

NEURAL REGENERATION RESEARCH (2022)

Add to Collection

Article Anesthesiology

Unbiased immune profiling reveals a natural killer cell-peripheral nerve axis in fibromyalgia

Vivek Verma et al.

Summary: The pathophysiology of fibromyalgia syndrome (FMS) is still unknown. This study found that patients with FMS had a decrease in natural killer (NK) cells, which were exhausted yet activated. Genetic and transcriptomic analysis showed enrichment of cell activation pathways in FMS driven by NK cells. Skin biopsies also revealed the presence of NK cells near subepidermal nerves in FMS patients.

PAIN (2022)

Add to Collection

Article Multidisciplinary Sciences

Neuropathic pain caused by miswiring and abnormal end organ targeting

Vijayan Gangadharan et al.

Summary: Nerve injury leads to chronic neuropathic pain characterized by allodynia and loss of sensation. The study reveals that reinnervation-induced neuropathic pain involves the sprouting of pain-sensing fibers into denervated areas, abnormal terminal connectivity, and malfunction of nociceptors. In contrast, touch-sensing fibers do not reinnervate, leading to aberrant innervation of tactile end organs.

NATURE (2022)

Add to Collection

Article Multidisciplinary Sciences

Neutrophil and natural killer cell imbalances prevent muscle stem cell-mediated regeneration following murine volumetric muscle loss

Jacqueline A. Larouche et al.

Summary: This study compares the cellular and molecular mechanisms of fibrotic degeneration or regeneration of skeletal muscle (SkM) following volumetric muscle loss (VML) injuries. The researchers found that degenerative VML injuries led to increased infiltration of natural killer (NK) cells and persistent presence of neutrophils. The persistent infiltration of neutrophils impaired the regenerative function of muscle stem cells, which can be alleviated by blocking TGF beta signaling.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Add to Collection

Article Multidisciplinary Sciences

Reversible CD8 T cell-neuron cross-talk causes aging- dependent neuronal regenerative decline

Luming Zhou et al.

Summary: Aging is associated with increased prevalence of axonal injuries, and the underlying mechanisms remain unclear. This study found that T cell signaling is enriched in mice before and after sciatic nerve injury (SNI), and this signaling promotes immune cell recruitment and axonal injury through the activation of specific proteins. Inhibition of T cell recruitment facilitates axonal regeneration.

SCIENCE (2022)

Add to Collection

Article Cell Biology

Acute inflammatory response via neutrophil activation protects against the development of chronic pain

Marc Parisien et al.

Summary: This study investigated the pathophysiological mechanisms underlying the transition from acute to chronic low back pain and found that inflammatory responses may play a protective role against the development of chronic pain. Early treatment with steroids or nonsteroidal anti-inflammatory drugs (NSAIDs) may provide short-term analgesic effects but could have detrimental effects on long-term outcomes of back pain sufferers.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Add to Collection

Article Medicine, Research & Experimental

CD8+ T cell-derived IL-13 increases macrophage IL-10 to resolve neuropathic pain

Susmita K. Singh et al.

Summary: Understanding the internal mechanisms that regulate pain resolution may lead to new treatment targets for chronic pain. The resolution of chemotherapy-induced peripheral neuropathy (CIPN) after treatment completion depends on CD8+ T cells and IL-10 produced by other cells.

JCI INSIGHT (2022)

Add to Collection

Article Biology

The injured sciatic nerve atlas (iSNAT), insights into the cellular and molecular basis of neural tissue degeneration and regeneration

Xiao-Feng Zhao et al.

Summary: This study performed single-cell analysis to investigate the pathological changes following nerve injury in mice. It was found that macrophages rapidly accumulated at the site of nerve injury and underwent metabolic reprogramming. The blood-nerve barrier showed partial leakiness, resulting in proliferation of stromal cells and entry of serum proteins. Distinct immune compartments were identified in response to mechanical nerve injury and Wallerian degeneration. Delayed Wallerian degeneration affected the distribution of immune cells in both the injured nerve and the distal nerve.

ELIFE (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Cellular senescence in neuroinflammatory disease: new therapies for old cells?

Christopher Nelke et al.

Summary: Neuroinflammatory diseases, particularly when progressing towards neurodegeneration, present a therapeutic challenge. Multiple sclerosis is a CNS disorder characterized by both inflammatory and degenerative processes. Current treatments are effective for managing inflammation, but not for chronic inflammation-induced neurodegenerative processes. Recent studies suggest that chronic neuroinflammation pathways exhibit cellular senescence features, which could be targeted for senotherapeutics.

TRENDS IN MOLECULAR MEDICINE (2022)

Add to Collection

Review Immunology

Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers

Sheena Pinto et al.

Summary: Bi-, tri- and multispecific antibodies have revolutionized targeted cancer immunotherapies, allowing immune effector cells to selectively eliminate malignant cells. However, there are still major challenges to overcome, such as enhancing efficacy in solid tumors and minimizing toxicities and immunogenicity.

TRENDS IN IMMUNOLOGY (2022)

Add to Collection

Review Anesthesiology

Omics approaches to discover pathophysiological pathways contributing to human pain

Luda Diatchenko et al.

PAIN (2022)

Add to Collection

Article Medicine, Research & Experimental

mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation

Calvin Wong et al.

Summary: The activation of mTORC2 triggered by tissue inflammation causes structural changes in nociceptive free nerve endings, leading to inflammatory pain. Inhibiting the regulatory protein Rictor of mTORC2 can prevent the elongation and branching of nociceptive fibers, reducing inflammatory pain hypersensitivity.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Add to Collection

Review Physiology

NEUROPATHIC PAIN: FROM MECHANISMS TO TREATMENT

Nanna Brix Finnerup et al.

Summary: Neuropathic pain is a common chronic pain condition caused by lesion or disease of the somatosensory nervous system, characterized by ongoing or intermittent spontaneous pain. Evoked pain may spread to neighboring areas and is associated with peripheral and central sensitization processes.

PHYSIOLOGICAL REVIEWS (2021)

Add to Collection

Review Oncology

Exploring the NK cell platform for cancer immunotherapy

Jacob A. Myers et al.

Summary: NK cells have innate potential to kill cancer cells, leading to the development of various NK cell-based therapies for cancer treatment. The main focus of NK cell therapy research is on optimizing sources of therapeutic NK cells and enhancing their cytotoxicity and persistence in the body.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes

Liliana M. Sanmarco et al.

Summary: This study identifies a subset of astrocytes that limit inflammation in the central nervous system by inducing T cell apoptosis through TRAIL-DR5 signaling. The expression of TRAIL in these astrocytes is regulated by interferon-gamma produced by meningeal NK cells, which is modulated by the gut microbiome.

NATURE (2021)

Add to Collection

Review Cell Biology

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Raffaella Di Micco et al.

Summary: Cellular senescence is characterized by permanent proliferation arrest and can occur in response to various stresses like telomere dysfunction. Apart from stress-induced senescence, it can also be part of controlled programs in biological processes like embryonic development. Senescent cells contribute to impaired tissue regeneration, chronic diseases, and organismal aging, but also present an opportunity for intervention in aging and associated diseases.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Cytokine receptor clustering in sensory neurons with an engineered cytokine fusion protein triggers unique pain resolution pathways

Judith Prado et al.

Summary: The study found that a fusion protein (IL4-10 FP) can redirect signaling pathways on sensory neurons by regulating cytokine receptors to alleviate persistent inflammatory pain. IL4-10 FP can resolve inflammatory pain in mice and promote clustering of IL-4 and IL-10 receptors on sensory neurons.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Article Cell Biology

Immune regulation of pain: Friend and foe

Annemieke Kavelaars et al.

Summary: The immune system and peripheral sensory nervous system communicate through shared mediators and receptors, playing both proinflammatory and anti-inflammatory roles. T cells and macrophages can enhance pain sensitivity while also promoting pain resolution.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Add to Collection

Review Oncology

The emerging role of off-the-shelf engineered natural killer cells in targeted cancer immunotherapy

Kellsye P. Fabian et al.

Summary: This review outlines the importance of NK cells in cancer treatment and the development of NK-92 cell line in CAR-engineering, demonstrating robust antitumor activity and potential as a next-generation off-the-shelf cell therapy platform.

MOLECULAR THERAPY-ONCOLYTICS (2021)

Add to Collection

Article Anesthesiology

Protective role of natural killer cells in neuropathic pain conditions

Josephine Lassen et al.

Summary: The research focused on identifying immune cell patterns in the cerebrospinal fluid of patients with herpes zoster neuralgia and polyneuropathy to understand their contribution to pain chronicity. The study found a negative correlation between the frequency of NK cells and mechanical pain sensitivity, suggesting that NK cells may play a protective role in preventing central sensitization and pain chronicity.

PAIN (2021)

Add to Collection

Article Immunology

High Dose Intravenous IgG Therapy Modulates Multiple NK Cell and T Cell Functions in Patients With Immune Dysregulation

Sarah M. McAlpine et al.

Summary: IVIG treatment has multiple effects on NK cell subsets and CD4(+) T cells, promoting resolution of inflammation in patients with immune dysregulation.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Immunology

How Do Uterine Natural Killer and Innate Lymphoid Cells Contribute to Successful Pregnancy?

Oisin Huhn et al.

Summary: Innate lymphoid cells (ILCs) are the most abundant immune cells in the uterine mucosa before and during pregnancy, with tissue-resident natural killer (NK) cells and ILCs being the main subsets. Recent advances in single-cell RNA sequencing and high dimensional flow and mass cytometry have significantly enhanced our understanding of the heterogeneity within the uILC compartment. These advancements may help answer key clinical questions regarding infertility, miscarriage, and pregnancy disorders related to uILC subsets.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in mice

Mithilesh Kumar Jha et al.

Summary: Macrophages play a critical role in peripheral nerve response to injury, with their metabolism dependent on genes like MCT1 influencing nerve regeneration speed. Manipulating macrophage metabolism through MCT1 may enhance recovery from peripheral nerve injuries, potentially offering new therapeutic approaches where approved medical therapies are lacking.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Add to Collection

Review Neurosciences

Capturing Novel Non-opioid Pain Targets

Clifford J. Woolf

BIOLOGICAL PSYCHIATRY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Tissue Determinants of Human NK Cell Development, Function, and Residence

Pranay Dogra et al.

CELL (2020)

Add to Collection

Article Multidisciplinary Sciences

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease

David Gate et al.

NATURE (2020)

Add to Collection

Review Neurosciences

Cytotoxic Immunity in Peripheral Nerve Injury and Pain

Alexander J. Davies et al.

FRONTIERS IN NEUROSCIENCE (2020)

Add to Collection

Article Multidisciplinary Sciences

Redefining the heterogeneity of peripheral nerve cells in health and autoimmunity

Jolien Wolbert et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Add to Collection

Article Multidisciplinary Sciences

Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

Stefano Garofalo et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Review Immunology

Targeting Natural Killer Cells for Improved Immunity and Control of the Adaptive Immune Response

Stephen Pierce et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Add to Collection

Article Anesthesiology

Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability

Geoffroy Laumet et al.

PAIN (2020)

Add to Collection

Review Immunology

Regulation of natural killer cell activity by glucocorticoids, serotonin, dopamine, and epinephrine

Silvia Capellino et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

Add to Collection

Review Geriatrics & Gerontology

Role of immune cells in the removal of deleterious senescent cells

Abhijit Kale et al.

IMMUNITY & AGEING (2020)

Add to Collection

Review Oncology

Tissue-Resident NK Cells: Development, Maturation, and Clinical Relevance

Elaheh Hashemi et al.

CANCERS (2020)

Add to Collection

Article Immunology

Depletion of NK Cells Improves Cognitive Function in the Alzheimer Disease Mouse Model

Yuanyue Zhang et al.

JOURNAL OF IMMUNOLOGY (2020)

Add to Collection

Article Clinical Neurology

NK cell markers predict the efficacy of IV immunoglobulins in CIDP

Anne K. Mausberg et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2020)

Add to Collection

Article Biology

Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement

Ashley L. Kalinski et al.

ELIFE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury

Alexander J. Davies et al.

CELL (2019)

Add to Collection

Review Cell Biology

Senescent cells: Living or dying is a matter of NK cells

Fabrizio Antonangeli et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity

Laurent Gauthier et al.

CELL (2019)

Add to Collection

Article Multidisciplinary Sciences

TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes

Roman Fischer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Add to Collection

Article Multidisciplinary Sciences

Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells

Nicole Marquardt et al.

NATURE COMMUNICATIONS (2019)

Add to Collection

Article Cell Biology

Activated CD8+ T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice

Maria Daglas et al.

CELL REPORTS (2019)

Add to Collection

Article Immunology

Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights Into Inflammatory Neuropathies

Michael Heming et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection

Article Critical Care Medicine

Persons with Chronic Spinal Cord Injury Have Decreased Natural Killer Cell and Increased Toll-Like Receptor/Inflammatory Gene Expression

Paige Herman et al.

JOURNAL OF NEUROTRAUMA (2018)

Add to Collection

Article Anesthesiology

Neuroinflammation of the spinal cord and nerve roots in chronic radicular pain patients

Daniel S. Albrecht et al.

PAIN (2018)

Add to Collection

Review Pharmacology & Pharmacy

Etiology and Pharmacology of Neuropathic Pain

Sascha R. A. Alles et al.

PHARMACOLOGICAL REVIEWS (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Innate Lymphoid Cells: 10 Years On

Eric Vivier et al.

CELL (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Natural killer cells in inflammation and autoimmunity

Beatrice Zitti et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2018)

Add to Collection

Review Immunology

Natural Killer Cells: Development, Maturation, and Clinical Utilization

Alex M. Abel et al.

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection

Article Clinical Neurology

Cytotoxic activity and subset populations of peripheral blood natural killer cells in patients with chronic pain

Jae Joon Yoon et al.

KOREAN JOURNAL OF PAIN (2018)

Add to Collection

Article Immunology

Impaired NK cell functionality and increased TNF-α production as biomarkers of chronic chikungunya arthritis and rheumatoid arthritis

Subrat Thanapati et al.

HUMAN IMMUNOLOGY (2017)

Add to Collection

Article Immunology

Brain Ischemia Suppresses Immunity in the Periphery and Brain via Different Neurogenic Innervations

Qiang Liu et al.

IMMUNITY (2017)

Add to Collection

Article Immunology

Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation

Shuhei Hosomi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Add to Collection

Article Neurosciences

Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration

Jane A. Lindborg et al.

JOURNAL OF NEUROSCIENCE (2017)

Add to Collection

Correction Biotechnology & Applied Microbiology

Breaking barriers to novel analgesic drug development (vol 16, pg 545, 2017)

Ajay S. Yekkirala et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Add to Collection

Article Multidisciplinary Sciences

Acetylcholine-producing NK cells attenuate CNS inflammation via modulation of infiltrating monocytes/macrophages

Wei Jiang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Add to Collection

Article Cell Biology

NKG2D ligands mediate immunosurveillance of senescent cells

Adi Sagiv et al.

AGING-US (2016)

Add to Collection

Review Biochemistry & Molecular Biology

RAS and downstream RAF-MEK and PI3K-AKT signaling in neuronal development, function and dysfunction

Jian Zhong

BIOLOGICAL CHEMISTRY (2016)

Add to Collection

Article Neurosciences

CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain

Karen Krukowski et al.

JOURNAL OF NEUROSCIENCE (2016)

Add to Collection

Article Neurosciences

Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation

Qiang Liu et al.

NATURE NEUROSCIENCE (2016)

Add to Collection

Review Multidisciplinary Sciences

Pain regulation by non-neuronal cells and inflammation

Ru-Rong Ji et al.

SCIENCE (2016)

Add to Collection

Review Chemistry, Medicinal

Resiniferatoxin: The Evolution of the Molecular Scalpel for Chronic Pain Relief

Dorothy Cimino Brown

PHARMACEUTICALS (2016)

Add to Collection

Article Integrative & Complementary Medicine

NK cells mediate the cumulative analgesic effect of electroacupuncture in a rat model of neuropathic pain

Yong-Hui Gao et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014)

Add to Collection

Article Immunology

Innate IFN-γ promotes development of experimental autoimmune encephalomyelitis: A role for NK cells and M1 macrophages

Lara S. Dungan et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2014)

Add to Collection

Article Anesthesiology

Schwann cell autophagy counteracts the onset and chronification of neuropathic pain

Sara Marinelli et al.

PAIN (2014)

Add to Collection

Article Multidisciplinary Sciences

Ischemic neurons recruit natural killer cells that accelerate brain infarction

Yan Gan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Add to Collection

Article Cell & Tissue Engineering

Activating Receptor NKG2D Targets RAE-1-Expressing Allogeneic Neural Precursor Cells in a Viral Model of Multiple Sclerosis

Jason G. Weinger et al.

STEM CELLS (2014)

Add to Collection

Article Multidisciplinary Sciences

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

Carolina Cebrian et al.

NATURE COMMUNICATIONS (2014)

Add to Collection

Article Cell & Tissue Engineering

Natural Killer Cell-Activating Receptor NKG2D Mediates Innate Immune Targeting of Allogeneic Neural Progenitor Cell Grafts

Lori K. Phillips et al.

STEM CELLS (2013)

Add to Collection

Article Immunology

Human NK Cells Induce Neutrophil Apoptosis via an NKp46-and Fas-Dependent Mechanism

Fredrik B. Thoren et al.

JOURNAL OF IMMUNOLOGY (2012)

Add to Collection

Article Immunology

Ras Activation Induces Expression of Raet1 Family NK Receptor Ligands

Xi V. Liu et al.

JOURNAL OF IMMUNOLOGY (2012)

Add to Collection

Review Clinical Neurology

The role of the immune system in the generation of neuropathic pain

Margarita Calvo et al.

LANCET NEUROLOGY (2012)

Add to Collection

Article Multidisciplinary Sciences

Cytotoxicity of CD56bright NK Cells towards Autologous Activated CD4+ T Cells Is Mediated through NKG2D, LFA-1 and TRAIL and Dampened via CD94/NKG2A

Natasja Nielsen et al.

PLOS ONE (2012)

Add to Collection

Article Multidisciplinary Sciences

Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity

Philipp A. Lang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Add to Collection

Review Immunology

Multiple Treg suppressive modules and their adaptability

James B. Wing et al.

FRONTIERS IN IMMUNOLOGY (2012)

Add to Collection

Article Immunology

Mapping of NKp46(+) cells in healthy human lymphoid and non-lymphoid tissues

Elena Tomasello et al.

FRONTIERS IN IMMUNOLOGY (2012)

Add to Collection

Review Immunology

Natural killer cell-triggered vascular transformation: maternal care before birth?

Jianhong Zhang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2011)

Add to Collection

Article Clinical Neurology

The effect of IgG levels on the number of natural killer cells and their Fc receptors in chronic inflammatory demyelinating polyradiculoneuropathy

A. B. Bohn et al.

EUROPEAN JOURNAL OF NEUROLOGY (2011)

Add to Collection

Article Microbiology

Expression of the RAE-1 Family of Stimulatory NK-Cell Ligands Requires Activation of the PI3K Pathway during Viral Infection and Transformation

Maria Tokuyama et al.

PLOS PATHOGENS (2011)

Add to Collection

Article Medicine, Research & Experimental

Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD8(+) T cells, leading to prolonged viral persistence and altered pathogenesis

Stephen N. Waggoner et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Add to Collection

Article Multidisciplinary Sciences

Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis

Kalle Soederstroem et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Add to Collection

Article Immunology

Cross talk between NK cells and adaptive immune cells Killers and beyond: NK-cell-mediated control of immune responses

Christopher E. Andoniou et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2008)

Add to Collection

Review Immunology

Noncytotoxic functions of NK Cells:: Direct pathogen restriction and assistance to adaptive immunity

Till Strowig et al.

JOURNAL OF IMMUNOLOGY (2008)

Add to Collection

Review Immunology

Up on the tightrope: natural killer cell activation and inhibition

Lewis L. Lanier

NATURE IMMUNOLOGY (2008)

Add to Collection

Review Immunology

Functions of natural killer cells

Eric Vivier et al.

NATURE IMMUNOLOGY (2008)

Add to Collection

Article Hematology

Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses

Shlomo Nedvetzki et al.

BLOOD (2007)

Add to Collection

Article Neurosciences

NKG2D-mediated cytotoxicity toward oligodendrocytes suggests a mechanism for tissue injury in multiple sclerosis

Philippe Saikali et al.

JOURNAL OF NEUROSCIENCE (2007)

Add to Collection

Article Immunology

Effect of acute pain on splenic NK cell activity, lymphocyte proliferation and cytokine production activities

Ali Sharify et al.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2007)

Add to Collection

Article Neurosciences

CD8+lymphocyte-mediated injury of dorsal root ganglion neurons during lentivirus infection: CD154-dependent cell contact neurotoxicity

Y Zhu et al.

JOURNAL OF NEUROSCIENCE (2006)

Add to Collection

Article Hematology

NK-dependent DC maturation is mediated by TNFα and IFNγ released upon engagement of the NKp30 triggering receptor

M Vitale et al.

BLOOD (2005)

Add to Collection

Article Immunology

Cutting edge:: NKG2D is a costimulatory receptor for human naive CD8+ T cells

K Maasho et al.

JOURNAL OF IMMUNOLOGY (2005)

Add to Collection

Article Immunology

Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming

A Martín-Fontecha et al.

NATURE IMMUNOLOGY (2004)

Add to Collection

Article Immunology

Pain, psychological variables, sleep quality, and natural killer cell activity in midlife women with and without fibromyalgia

CA Landis et al.

BRAIN BEHAVIOR AND IMMUNITY (2004)

Add to Collection

Article Immunology

The corticosteroid-induced inhibitory effect on NK cell function reflects down-regulation and/or dysfunction of triggering receptors involved in natural cytotoxicity

C Vitale et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2004)

Add to Collection

Article Immunology

Dendritic cells mediate NK cell help for Th1 and CTL responses: Two-signal requirement for the induction of NK cell helper function

RB Mailliard et al.

JOURNAL OF IMMUNOLOGY (2003)

Add to Collection

Article Immunology

Natural killer cell-mediated lysis of dorsal root ganglia neurons via RAE1/NKG2D interactions

E Backstrom et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2003)

Add to Collection

Review Endocrinology & Metabolism

Chronic pain, chronic stress and depression: Coincidence or consequence?

G Blackburn-Munro et al.

JOURNAL OF NEUROENDOCRINOLOGY (2001)

Add to Collection

Article Neurosciences

Cytotoxic targeting of isolectin IB4-binding sensory neurons

L Vulchanova et al.

NEUROSCIENCE (2001)

Add to Collection

Article Immunology

Flow cytometric analysis of infiltrating cells in the peripheral nerves in experimental allergic neuritis

T Fujioka et al.

JOURNAL OF NEUROIMMUNOLOGY (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.