4.7 Editorial Material

Macrolide esterases: current threats and opportunities

Journal

TRENDS IN MICROBIOLOGY
Volume 31, Issue 12, Pages 1199-1201

Publisher

CELL PRESS
DOI: 10.1016/j.tim.2023.08.008

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This forum discusses the important role of bacterial macrolide esterases in antibiotics, as well as their potential applications in agricultural systems and bioremediation efforts.
Antibiotics often contain ester bonds. The macrocyclic lactones of macrolides are pre-eminent examples in which ester bonds are essential to the form and function of antibiotics. Bacterial macrolide esterases that hydrolyze these macrocyclic lactones to confer antimicrobial resistance (AMR) are the topic of this forum. We provide insight into their role in agricultural systems and discuss their emergence and their potential extensibility to bioremediation efforts.

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