4.6 Editorial Material

Decoding a ribosome uncertainty

Journal

TRENDS IN GENETICS
Volume 39, Issue 9, Pages 639-641

Publisher

CELL PRESS
DOI: 10.1016/j.tig.2023.06.001

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The ribosome is an ancient macromolecular complex responsible for decoding mRNA and synthesizing proteins. A recent study by Holm et al. reveals evolutionary distinctions in the structure and kinetics of mRNA decoding by the human ribosome.
The ribosome is among the most ancient macromolecular complexes. Throughout evolution, the function of the ribosome has remained essential and conserved: the decoding of an mRNA template with tRNA-linked amino acids, to synthesize a protein. In a recent study, Holm et al. capture evolutionary distinctions in the structure and kinetics of 'mRNA decoding' by the human ribosome.

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