☆ 4.6 Review

Neural stem cell metabolism revisited: a critical role for mitochondria

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2023)

Related references

Note: Only part of the references are listed.

Article Cell Biology

D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase

Yinghao Liu et al.

Summary: The balance between quiescent and activated radial-glia-like neural stem cells (RGLs) in the adult brain is regulated by the metabolic program. However, the role of mitochondrial metabolite D-2-hydroxyglutarate (D-2-HG) in this process is still unclear. In this study, it was found that the accumulation of D-2-HG inhibits histone acetylation in RGL activation by directly binding to ATP-citrate lyase and reducing acetyl-CoA production. However, supplementation of acetate restores acetyl-CoA levels and rescues the deficiencies in histone acetylation and RGL activation caused by loss of D2HGDH.

CELL REPORTS (2023)

Add to Collection

Review Cell Biology

Ageing and rejuvenation of tissue stem cells and their niches

Anne Brunet et al.

Summary: Stem cell function declines during ageing, resulting in the loss of tissue integrity and health deterioration. This Review discusses the mechanisms underlying ageing in stem cells and their niches, and potential rejuvenation strategies.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2023)

Add to Collection

Article Cell & Tissue Engineering

Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer?s disease

Ya-Dong Li et al.

Summary: Patients with Alzheimer's disease (AD) show memory loss, depression, and anxiety, along with impaired adult hippocampal neurogenesis (AHN). This study demonstrates that optogenetic stimulation of the hypothalamic supramammillary nucleus (SuM) enhances AHN in AD mouse models, improving memory and emotion deficits. Activation of SuM-enhanced adult-born neurons (ABNs) triggers synaptic plasticity and microglia phagocytosis, providing insights into the signaling mechanisms involved.

CELL STEM CELL (2023)

Add to Collection

Article Multidisciplinary Sciences

Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Kevin G. Hicks et al.

Summary: Metabolic networks play a crucial role in various cellular processes. Discovering low-affinity protein-metabolite interactions that govern these networks is challenging. A new method, called mass spectrometry integrated with equilibrium dialysis for the discovery of allostery systematically (MIDAS), was developed to identify such interactions. In a study involving enzymes from human carbohydrate metabolism, 830 protein-metabolite interactions were discovered, including both known and unknown interactions. Some of these interactions were functionally validated, revealing the isoform-specific inhibition of lactate dehydrogenase by long-chain acyl-coenzyme A. The findings suggest that these protein-metabolite interactions contribute to the adaptive metabolic flexibility in different tissues.

SCIENCE (2023)

Add to Collection

Article Multidisciplinary Sciences

Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells

Francesco Petrelli et al.

Summary: Cellular metabolism plays a crucial role in the behavior of adult neural stem/progenitor cells (NSPCs). The mitochondrial pyruvate carrier (MPC) is identified as an important factor in controlling NSPC quiescence and activation.

SCIENCE ADVANCES (2023)

Add to Collection

Article Cell Biology

Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L

Gulzar A. Wani et al.

Summary: This study reveals the importance of YME1L peptidase in regulating the self-renewal of neural stem and progenitor cells (NSPCs). YME1L controls the rewiring of the mitochondrial proteome, ensuring the metabolic plasticity of NSPCs and preventing premature differentiation.

CELL REPORTS (2022)

Add to Collection

Review Cell Biology

Imaging Approaches for the Study of Metabolism in Real Time Using Genetically Encoded Reporters

Panagiotis Chandris et al.

Summary: This article provides an overview of available tools for monitoring the dynamics of biochemical reactions and the kinetics of metabolites, and discusses the potential for developing new methodologies that combine classical biochemistry with advanced imaging.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications

Alexandria N. Tartt et al.

Summary: This review takes a top-down approach to assess how changes in behavior and hippocampal-dependent circuits may be attributed to abnormalities at the molecular, structural, and synaptic level. The discussion focuses on the common effect of antidepressant treatments in modulating neuroplasticity and considers outstanding questions and future perspectives.

MOLECULAR PSYCHIATRY (2022)

Add to Collection

Review Cell Biology

Metabolic regulation of somatic stem cells in vivo

Corbin E. Meacham et al.

Summary: The metabolism of somatic stem cells plays a crucial role in their long-term maintenance, activation, proliferation, and differentiation. Understanding the metabolic regulation in stem cells can lead to new opportunities in manipulating their functions, which can have applications in tissue regeneration and cancer prevention. Recent evidence suggests that stem cells have distinct metabolic characteristics compared to restricted progenitors and that metabolic changes influence tissue homeostasis and regeneration. Stem cell metabolism is influenced by the microenvironment and can interact with other cells in their niches.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Spatially resolved proteomics via tissue expansion

Lu Li et al.

Summary: This paper describes a spatially resolved proteomics method called Expansion Proteomics (ProteomEx), which combines tissue expansion with mass spectrometry-based proteomics. The method allows quantitative profiling of proteome variability in mammalian tissues using manual microsampling, without the need for custom equipment. The authors validated the method by analyzing brain, liver, and breast cancer samples, and demonstrated its utility by identifying proteins associated with Alzheimer's disease in a mouse model.

NATURE COMMUNICATIONS (2022)

Add to Collection

Review Neurosciences

Radial glia and radial glia-like cells: Their role in neurogenesis and regeneration

Yamil Miranda-Negron et al.

Summary: Radial glia-like cells, traditionally associated with the developing nervous system, are also found in the adult central nervous system where they function as neurogenic progenitors in normal homeostasis and injury response. Molecular tools have been used to probe the heterogeneity of these cells and similar cells have been identified in non-vertebrate organisms.

FRONTIERS IN NEUROSCIENCE (2022)

Add to Collection

Article Neurosciences

Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex

Xiaoxiang Dong et al.

Summary: The study shows that proliferative neural progenitors in the developing neocortex preferentially undergo anaerobic glycolysis, producing a high level of lactate that coordinately regulates vascular outgrowth and progenitor behavior. The findings reveal the metabolic regulation of neural progenitor behavior and vessel growth in neocortical development.

NATURE NEUROSCIENCE (2022)

Add to Collection

Article Immunology

Augmenting neurogenesis rescues memory impairments in Alzheimer's disease by restoring the memory-storing neurons

Rachana Mishra et al.

Summary: Deficits in hippocampal neurogenesis impair memory storage in Alzheimer's disease. Augmenting neurogenesis rescues memory by recruiting more new neurons. The recruitment of immature neurons is severely deficient in familial Alzheimer's disease (FAD), but can be restored through targeted augmentation of neurogenesis, leading to the rescue of memory.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

Add to Collection

Review Neurosciences

Astrocyte development in the cerebral cortex: Complexity of their origin, genesis, and maturation

Solene Clavreul et al.

Summary: In the mammalian brain, astrocytes form a diverse population with variations in morphology, molecular makeup, function, and location. Recent studies have shed light on the development and maturation of astrocytes in the cerebral cortex, providing a better understanding of their diversity. However, the origins of this diversity are still unclear, and further research using advanced tools and techniques is underway.

FRONTIERS IN NEUROSCIENCE (2022)

Add to Collection

Article Multidisciplinary Sciences

Ketogenic diet uncovers differential metabolic plasticity of brain cells

Tim Duking et al.

Summary: This study provides insights into the energy metabolism of different brain cell types in response to altered nutrition and neurological disease, highlighting the importance of metabolic cross-talk between CNS cells and between the periphery and the brain.

SCIENCE ADVANCES (2022)

Add to Collection

Review Developmental Biology

Mitochondrial respiration and dynamics of in vivo neural stem cells

Stavroula Petridi et al.

Summary: Mitochondria play a central role in the behavior and fate decisions of neural stem cells, influencing cellular metabolism and the activity of chromatin-modifying enzymes.

DEVELOPMENT (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Aβ-induced mitochondrial dysfunction in neural progenitors controls KDM5A to influence neuronal differentiation

Dong Kyu Kim et al.

Summary: This study reveals the crucial role of mitochondria in neural progenitors and their association with the protein amyloid-beta, which is linked to Alzheimer's disease. Mitochondrial dysfunction inhibits neuronal differentiation, leading to deficits in adult hippocampal neurogenesis and cognitive function. The research suggests that lysine demethylase 5A epigenetically suppresses differentiation in response to mitochondrial damage.

EXPERIMENTAL AND MOLECULAR MEDICINE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Adult neural stem cell activation in mice is regulated by the day/night cycle and intracellular calcium dynamics

Archana Gengatharan et al.

Summary: The study found that melatonin signaling affects neural stem cell activation, while multiple microenvironmental signals converge on intracellular Ca2+ pathways to regulate the quiescence and activation of neural stem cells.

CELL (2021)

Add to Collection

Article Cell & Tissue Engineering

ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence

Vijay S. Adusumilli et al.

Summary: The study discovered that quiescent neural precursor cells (NPCs) in the hippocampus of adult mice maintain the highest levels of intracellular reactive oxygen species (ROS). Different functional states of NPCs were identified based on their ROS content, and physical activity was found to recruit NPCs with high ROS levels into proliferation. This mechanism provides a link between the modulation of cellular ROS by behavioral cues and the activation of adult NPCs.

CELL STEM CELL (2021)

Add to Collection

Article Neurosciences

Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging

Sara Bottes et al.

Summary: Researchers identified long-term self-renewing neural stem cells (NSCs) in the adult mouse hippocampus using intravital imaging and single-cell RNA sequencing. They found that Gli1-targeted NSCs exhibit long-term self-renewal, while Ascl1-targeted NSCs have limited proliferative activity before exhaustion. The study revealed the existence of heterogeneous NSC populations with diverse behavioral properties in contributing to neurogenesis in the adult hippocampus.

NATURE NEUROSCIENCE (2021)

Add to Collection

Review Multidisciplinary Sciences

Mapping the molecular and cellular complexity of cortical malformations

Esther Klingler et al.

Summary: This article discusses the composition of the cerebral cortex, the causes of neurodevelopmental disorders, and the importance of a multilevel assessment of disease processes for developing therapeutic strategies.

SCIENCE (2021)

Add to Collection

Article Cell & Tissue Engineering

Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population

Lachlan Harris et al.

Summary: The stabilization of neural stem cell numbers in young adults is a result of coordinated changes in stem cell behavior, with resting cells having a higher activation rate and greater contribution to neurogenesis. This change is associated with a progressive reduction in expression of the pro-activation protein ASCL1 due to increased post-translational degradation, providing insights into hippocampal NSC dynamics and neurogenesis rates in different mammalian species, including humans.

CELL STEM CELL (2021)

Add to Collection

Article Biochemical Research Methods

Spatially Resolved Mass Spectrometry at the Single Cell: Recent Innovations in Proteomics and Metabolomics

Michael J. Taylor et al.

Summary: Biological systems consist of heterogeneous populations of cells that intercommunicate to form functional tissues, with each single cell possessing unique transcriptome, proteome, and metabolome leading to functional differences. Advancements in characterizing omic profiles at a single cell level, including spatially resolved mass spectrometry techniques, have progressed significantly over the past decade.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2021)

Add to Collection

Review Neurosciences

Formation and integration of new neurons in the adult hippocampus

Annina Denoth-Lippuner et al.

Summary: In this Review, recent advances in adult hippocampal neurogenesis in rodents are presented, focusing on the distinct developmental steps and regulatory mechanisms, as well as the impact of newborn neurons on brain function.

NATURE REVIEWS NEUROSCIENCE (2021)

Add to Collection

Article Multidisciplinary Sciences

Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

J. Terreros-Roncal et al.

Summary: Disrupted hippocampal performance is a major factor contributing to psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. Adult hippocampal neurogenesis (AHN) plays a crucial role in several neurodegenerative diseases, with abnormalities found in adult-born dentate granule cells. Aging and diseases alter the neurogenic niche, reduce microglial phagocytic capacity, trigger astrogliosis, and change the microvasculature of the dentate gyrus, leading to enhanced vulnerability of AHN to neurodegeneration.

SCIENCE (2021)

Add to Collection

Review Cell Biology

Regulation of Adult Mammalian Neural Stem Cells and Neurogenesis by Cell Extrinsic and Intrinsic Factors

Shuzo Matsubara et al.

Summary: Tissue-specific stem cells generate new functional cells to maintain tissue homeostasis and repair damaged tissue. Neurogenesis of endogenous NSCs alone is insufficient for complete brain repair, leading to exploration of direct reprogramming as an innovative approach. This review discusses the control of NSCs and neurogenesis in the adult brain, as well as the potential of direct neuronal reprogramming for future clinical applications.

CELLS (2021)

Add to Collection

Article Cell Biology

The requirement for pyruvate dehydrogenase in leukemogenesis depends on cell lineage

Sojeong Jun et al.

Summary: Cancer cells have metabolic similarities with normal tissues, but differences may be due to reprogramming during transformation or maintenance of specific cell type metabolism. This study compared glucose metabolism in hematopoiesis and leukemia, finding that PDH deletion affects the development of T cell leukemia but not myeloid neoplasms, emphasizing the role of PDH in maintaining normal cell metabolism in leukemia.

CELL METABOLISM (2021)

Add to Collection

Article Neurosciences

Regulatory roles of mitochondria and metabolism in neurogenesis

Ryohei Iwata et al.

Summary: Neural stem cells undergo massive changes in mitochondria and metabolism during neuronal differentiation, influencing cell fate through metabolic rewiring and gene expression changes. The impact of mitochondria and metabolism on neurogenesis is essential and conserved across species, with notable differences based on cell context.

CURRENT OPINION IN NEUROBIOLOGY (2021)

Add to Collection

Review Behavioral Sciences

Adult neurogenesis, human after all (again): Classic, optimized, and future approaches

Paul J. Lucassen et al.

BEHAVIOURAL BRAIN RESEARCH (2020)

Add to Collection

Article Cell & Tissue Engineering

Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency

Raymond Liang et al.

CELL STEM CELL (2020)

Add to Collection

Review Cell Biology

The cell biology of mitochondrial membrane dynamics

Marta Giacomello et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Add to Collection

Article Biochemical Research Methods

Fluorescence lifetime imaging microscopy: fundamentals and advances in instrumentation, analysis, and applications

Rupsa Datta et al.

JOURNAL OF BIOMEDICAL OPTICS (2020)

Add to Collection

Review Cell Biology

Hematopoietic Stem Cell Metabolism during Development and Aging

Ayako Nakamura-Ishizu et al.

DEVELOPMENTAL CELL (2020)

Add to Collection

Review Cell & Tissue Engineering

Aging and Rejuvenation of Neural Stem Cells and Their Niches

Paloma Navarro Negredo et al.

CELL STEM CELL (2020)

Add to Collection

Article Cell Biology

Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle

Christine S. Kim et al.

CELL METABOLISM (2020)

Add to Collection

Article Multidisciplinary Sciences

Mitochondrial dynamics in postmitotic cells regulate neurogenesis

Ryohei Iwata et al.

SCIENCE (2020)

Add to Collection

Article Multidisciplinary Sciences

Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction

E. Motori et al.

SCIENCE ADVANCES (2020)

Add to Collection

Review Biochemistry & Molecular Biology

The role of adult hippocampal neurogenesis in brain health and disease

Tomohisa Toda et al.

MOLECULAR PSYCHIATRY (2019)

Add to Collection

Review Hematology

Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities

Marie-Dominique Filippi et al.

BLOOD (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain

Georgios Kalamakis et al.

CELL (2019)

Add to Collection

Article Biochemistry & Molecular Biology

A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis

Daniel A. Berg et al.

CELL (2019)

Add to Collection

Article Cell Biology

Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells

Yilin Yu et al.

CELL METABOLISM (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease

Elena P. Moreno-Jimenez et al.

NATURE MEDICINE (2019)

Add to Collection

Article Multidisciplinary Sciences

A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP

Mark A. Lobas et al.

NATURE COMMUNICATIONS (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

Maria S. Ioannou et al.

CELL (2019)

Add to Collection

Article Multidisciplinary Sciences

Single-cell analysis reveals T cell infiltration in old neurogenic niches

Ben W. Dulken et al.

NATURE (2019)

Add to Collection

Article Cell Biology

Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function

Nora Yucel et al.

CELL REPORTS (2019)

Add to Collection

Review Biochemistry & Molecular Biology

The paradox of metabolism in quiescent stem cells

Hilary A. Coller

FEBS LETTERS (2019)

Add to Collection

Article Biology

Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation

Jelle van den Ameele et al.

ELIFE (2019)

Add to Collection

Article Neurosciences

Mitochondrial Complex I Function Is Essential for Neural Stem/Progenitor Cells Proliferation and Differentiation

Daniel Cabello-Rivera et al.

FRONTIERS IN NEUROSCIENCE (2019)

Add to Collection

Article Multidisciplinary Sciences

Enhanced lysosomal degradation maintains the quiescent state of neural stem cells

Taeko Kobayashi et al.

NATURE COMMUNICATIONS (2019)

Add to Collection

Article Multidisciplinary Sciences

Mitochondria modulate programmed neuritic retraction

Sergei V. Baranov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Add to Collection

Review Neurosciences

Quiescence of Adult Mammalian Neural Stem Cells: A Highly Regulated Rest

Noelia Urban et al.

NEURON (2019)

Add to Collection

Article Biochemical Research Methods

Spatially-Resolved Top-down Proteomics Bridged to MALDI MS Imaging Reveals the Molecular Physiome of Brain Regions

Vivian Delcourt et al.

MOLECULAR & CELLULAR PROTEOMICS (2018)

Add to Collection

Article Cell & Tissue Engineering

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

Maria M. Mihaylova et al.

CELL STEM CELL (2018)

Add to Collection

Review Cell & Tissue Engineering

Human Adult Neurogenesis: Evidence and Remaining Questions

Gerd Kempermann et al.

CELL STEM CELL (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Lysosomal acid lipase and lipid metabolism: new mechanisms, new questions, and new therapies

Hanrui Zhang

CURRENT OPINION IN LIPIDOLOGY (2018)

Add to Collection

Article Multidisciplinary Sciences

Troy plus brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

Onur Basak et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Add to Collection

Article Multidisciplinary Sciences

Live imaging of neurogenesis in the adult mouse hippocampus

Gregor-Alexander Pilz et al.

SCIENCE (2018)

Add to Collection

Article Multidisciplinary Sciences

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

Dena S. Leeman et al.

SCIENCE (2018)

Add to Collection

Review Anatomy & Morphology

Neural Progenitor Cell Terminology

Veronica Martinez-Cerdeno et al.

FRONTIERS IN NEUROANATOMY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis

Mireille Khacho et al.

HUMAN MOLECULAR GENETICS (2017)

Add to Collection

Article Multidisciplinary Sciences

Interplay between metabolic identities in the intestinal crypt supports stem cell function

Maria J. Rodriguez-Colman et al.

NATURE (2017)

Add to Collection

Article Cell Biology

Lactate dehydrogenase activity drives hair follicle stem cell activation

Aimee Flores et al.

NATURE CELL BIOLOGY (2017)

Add to Collection

Article Cell Biology

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

John C. Schell et al.

NATURE CELL BIOLOGY (2017)

Add to Collection

Article Neurosciences

Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

Ruth Beckervordersandforth et al.

NEURON (2017)

Add to Collection

Article Cell Biology

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity

Marlen Knobloch et al.

CELL REPORTS (2017)

Add to Collection

Article Cell Biology

Single-Cell Transcriptomic Analysis Defines Heterogeneity and Transcriptional Dynamics in the Adult Neural Stem Cell Lineage

Ben W. Dulken et al.

CELL REPORTS (2017)

Add to Collection

Article Cell Biology

Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells

Shugo Tohyama et al.

CELL METABOLISM (2016)

Add to Collection

Article Cell Biology

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

Philipp Machler et al.

CELL METABOLISM (2016)

Add to Collection

Article Cell & Tissue Engineering

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

Mireille Khacho et al.

CELL STEM CELL (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis

Christian Lange et al.

EMBO JOURNAL (2016)

Add to Collection

Review Cell Biology

Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing

Navdeep S. Chandel et al.

NATURE CELL BIOLOGY (2016)

Add to Collection

Article Biochemical Research Methods

In vivo monitoring of cellular energy metabolism using SoNar, a highly responsive sensor for NAD+/NADH redox state

Yuzheng Zhao et al.

NATURE PROTOCOLS (2016)

Add to Collection

Article Multidisciplinary Sciences

Return to quiescence of mouse neural stem cells by degradation of a proactivation protein

Noelia Urban et al.

SCIENCE (2016)

Add to Collection

Review Cell Biology

Energy metabolism in the acquisition and maintenance of stemness

Clifford D. L. Folmes et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2016)

Add to Collection

Article Cell Biology

Inborn Errors of Long-Chain Fatty Acid β-Oxidation Link Neural Stem Cell Self-Renewal to Autism

Zhigang Xie et al.

CELL REPORTS (2016)

Add to Collection

Article Biology

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

Xinde Zheng et al.

eLife (2016)

Add to Collection

Review Biochemistry & Molecular Biology

Metabolic Regulation of Histone Post-Translational Modifications

Jing Fan et al.

ACS CHEMICAL BIOLOGY (2015)

Add to Collection

Article Biochemistry & Molecular Biology

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

Kivanc Birsoy et al.

CELL (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

Lucas B. Sullivan et al.

CELL (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Embryonic Origin of Postnatal Neural Stem Cells

Luis C. Fuentealba et al.

CELL (2015)

Add to Collection

Review Cell & Tissue Engineering

Metabolic Reprogramming of Stem Cell Epigenetics

James G. Ryall et al.

CELL STEM CELL (2015)

Add to Collection

Article Cell & Tissue Engineering

Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis

Jaehoon Shin et al.

CELL STEM CELL (2015)

Add to Collection

Article Cell & Tissue Engineering

The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

James G. Ryall et al.

CELL STEM CELL (2015)

Add to Collection

Article Cell & Tissue Engineering

Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury

Enric Llorens-Bobadilla et al.

CELL STEM CELL (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Resistance of glia-like central and peripheral neural stem cells to genetically induced mitochondrial dysfunctiondifferential effects on neurogenesis

Blanca Diaz-Castro et al.

EMBO REPORTS (2015)

Add to Collection

Article Neurosciences

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells

Shohei Furutachi et al.

NATURE NEUROSCIENCE (2015)

Add to Collection

Article Cell & Tissue Engineering

Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity

Elizabeth A. Stoll et al.

STEM CELLS (2015)

Add to Collection

Article Multidisciplinary Sciences

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

Maria Maryanovich et al.

NATURE COMMUNICATIONS (2015)

Add to Collection

Article Multidisciplinary Sciences

Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system

Antonis Koussounadis et al.

SCIENTIFIC REPORTS (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Ecdysone and Mediator Change Energy Metabolism to Terminate Proliferation in Drosophila Neural Stem Cells

Catarina C. F. Homem et al.

CELL (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo

Michael Breckwoldt et al.

NATURE MEDICINE (2014)

Add to Collection

Article Multidisciplinary Sciences

Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy

Katherine G. Akers et al.

SCIENCE (2014)

Add to Collection

Editorial Material Neurosciences

Adult neurogenesis in brain repair: cellular plasticity vs. cellular replacement

Giorgia Quadrato et al.

FRONTIERS IN NEUROSCIENCE (2014)

Add to Collection

Article Cell & Tissue Engineering

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

Keiyo Takubo et al.

CELL STEM CELL (2013)

Add to Collection

Review Biochemistry & Molecular Biology

Understanding Metabolic Regulation and Its Influence on Cell Physiology

Christian M. Metallo et al.

MOLECULAR CELL (2013)

Add to Collection

Article Multidisciplinary Sciences

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

Marlen Knobloch et al.

NATURE (2013)

Add to Collection

Review Cell Biology

Molecular regulation of stem cell quiescence

Tom H. Cheung et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Add to Collection

Article Multidisciplinary Sciences

Drosophila Clueless Is Highly Expressed in Larval Neuroblasts, Affects Mitochondrial Localization and Suppresses Mitochondrial Oxidative Damage

Aditya Sen et al.

PLOS ONE (2013)

Add to Collection

Review Cell & Tissue Engineering

Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal

Jin Zhang et al.

CELL STEM CELL (2012)

Add to Collection

Article Developmental Biology

Drosophila neuroblasts: a model for stem cell biology

Catarina C. F. Homem et al.

DEVELOPMENT (2012)

Add to Collection

Article Cell Biology

Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate

Victoria A. Rafalski et al.

JOURNAL OF CELL SCIENCE (2012)

Add to Collection

Article Biochemistry & Molecular Biology

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

Keisuke Ito et al.

NATURE MEDICINE (2012)

Add to Collection

Review Cell Biology

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

Sophia Y. Lunt et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)

Add to Collection

Article Biochemistry & Molecular Biology

In Vivo Clonal Analysis Reveals Self-Renewing and Multipotent Adult Neural Stem Cell Characteristics

Michael A. Bonaguidi et al.

CELL (2011)

Add to Collection

Article Cell Biology

Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming

Clifford D. L. Folmes et al.

CELL METABOLISM (2011)

Add to Collection

Article Multidisciplinary Sciences

Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts

Sandra Varum et al.

PLOS ONE (2011)

Add to Collection

Article Cell & Tissue Engineering

Human Induced Pluripotent Stem Cells Harbor Homoplasmic and Heteroplasmic Mitochondrial DNA Mutations While Maintaining Human Embryonic Stem Cell-like Metabolic Reprogramming

Alessandro Prigione et al.

STEM CELLS (2011)

Add to Collection

Article Cell Biology

A Drosophila model for primary coenzyme Q deficiency and dietary rescue in the developing nervous system

Jennifer Grant et al.

DISEASE MODELS & MECHANISMS (2010)

Add to Collection

Article Geriatrics & Gerontology

Early age-related changes in adult hippocampal neurogenesis in C57 mice

Nada M. -B. Ben Abdallah et al.

NEUROBIOLOGY OF AGING (2010)

Add to Collection

Article Neurosciences

The Glial Nature of Embryonic and Adult Neural Stem Cells

Arnold Kriegstein et al.

Annual Review of Neuroscience (2009)

Add to Collection

Article Biochemistry & Molecular Biology

Correlation of mRNA and protein in complex biological samples

Tobias Maier et al.

FEBS LETTERS (2009)

Add to Collection

Review Biochemistry & Molecular Biology

The key role of anaplerosis and cataplerosis for citric acid cycle function

OE Owen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.