Journal
MUCOSAL IMMUNOLOGY
Volume 10, Issue 1, Pages 27-34Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mi.2016.86
Keywords
-
Categories
Funding
- Institut Pasteur
Ask authors/readers for more resources
ROR gamma t is a nuclear hormone receptor that has followed an exponential success carrier. Its modest origins as an orphan receptor cloned from human pancreas blossomed within 15 years into a critical regulator of anti-microbial immunity and a major target in the fight against inflammatory pathologies. Here, I review its role as a transcription factor required for the generation of type 3 lymphoid cells, which induce the development of lymphoid tissues, provide resistance of epithelial stem cells to injury, maintain homeostasis with the symbiotic microbiota, orchestrate defense against extracellular microbes, and regulate allergic responses. ROR gamma t is also an intriguing molecule that is regulated by the circadian rhythm and includes cholesterol metabolites as ligands. ROR gamma t therefore links anti-microbial immunity with circadian rhythms and steroids, the logic of which remains to be understood.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available