Journal
MUCOSAL IMMUNOLOGY
Volume 9, Issue 6, Pages 1487-1499Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mi.2016.5
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Funding
- German Research Council (DFG) [SFB633, SFB 650, GRK1121]
- European Research Council [ERC-2010-AdG_20100317, 268987]
- e:Bio Innovationswettbewerb Systembiologie'' program of the Federal Ministry of Education
- EUTRAIN
- FP7 Marie Curie Initial Training Network for Early Stage Researchers - European Union
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The transcription factor T-bet is highly expressed by Th cells isolated from the inflamed intestine of Crohn's disease patients, and has been regarded a critical driver of murine T cell-induced colitis. However, we show here that T-bet expression by Th cells is not required for the manifestation of T-cell-induced colitis in the presence of segmented filamentous bacteria and Helicobacter hepaticus. T-bet expression by Th cells controls their survival and localization, their repertoire of chemokine and chemokine receptor expression, the accumulation of monocytes and macrophages in the inflamed colon, and their differentiation to the M1 type, i.e., type 1 inflammation. Nevertheless, T-bet-deficient Th cells efficiently induce colitis, as reflected by weight loss, diarrhea, and colon histopathology. T-bet-deficient Th cells differentiate into Th1/17 cells, able to express IFN-gamma and IL-17A upon restimulation. While neutralization of IL-17A exacerbated colitis induced by wild-type or T-bet-deficient Th cells, neutralization of IFN-gamma completely abolished colitis.
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