Journal
MUCOSAL IMMUNOLOGY
Volume 9, Issue 3, Pages 583-586Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mi.2016.17
Keywords
-
Categories
Funding
- National Health and Medical Research Council of Australia
- Australian Research Council
Ask authors/readers for more resources
Celiac disease is an autoimmune-like disorder that is triggered by dietary gluten and has a strong genetic association with the human leukocyte antigen locus, specifically, HLA-DQ2.5/DQ8. Here, Dahai-Koirala et al. apply ex vivo single-cell sequencing of TCRs from celiac disease patients, and show that biased T-cell receptor usage underpins the response to two gluten epitopes, which has implications for disease pathogenesis, diagnosis, and treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available