Related references
Note: Only part of the references are listed.Genes associated with Parkinson's disease: regulation of autophagy and beyond
Alexandra Beilina et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes
Wenzhang Wang et al.
NATURE MEDICINE (2016)
A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death
Tomas Lopes da Fonseca et al.
HUMAN MOLECULAR GENETICS (2016)
Loss of ATP13A2 impairs glycolytic function in Kufor-Rakeb syndrome patient-derived cell models
Jin-Sung Park et al.
PARKINSONISM & RELATED DISORDERS (2016)
α-Synuclein-Independent Histopathological and Motor Deficits in Mice Lacking the Endolysosomal Parkinsonism Protein Atp13a2
Lauren R. Kett et al.
JOURNAL OF NEUROSCIENCE (2015)
VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease
Fu-Lei Tang et al.
JOURNAL OF NEUROSCIENCE (2015)
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson's Disease
Alicia M. Pickrell et al.
NEURON (2015)
Juvenile dystonia-parkinsonism syndrome caused by a novel p.S941Tfs1X ATP13A2 (PARK9) mutation
D. Martino et al.
PARKINSONISM & RELATED DISORDERS (2015)
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein
Ryan P. McGlinchey et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
A lipid switch unlocks Parkinson's disease-associated ATP13A2
Tine Holemans et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease
Brent J. Ryan et al.
TRENDS IN BIOCHEMICAL SCIENCES (2015)
VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function
Fu-Lei Tang et al.
CELL REPORTS (2015)
VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation
Yun Tian et al.
MOLECULAR BRAIN (2015)
Complex lipid trafficking in Niemann-Pick disease type C
Marie T. Vanier
JOURNAL OF INHERITED METABOLIC DISEASE (2015)
DNAJC13 mutations in Parkinson disease
Carles Vilarino-Gueell et al.
HUMAN MOLECULAR GENETICS (2014)
Zn2+ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation
Taiji Tsunemi et al.
HUMAN MOLECULAR GENETICS (2014)
Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes
Stephanie M. Y. Kong et al.
HUMAN MOLECULAR GENETICS (2014)
Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction
Jin-Sung Park et al.
HUMAN MOLECULAR GENETICS (2014)
A Direct Interaction between Leucine-rich Repeat Kinase 2 and Specific β-Tubulin Isoforms Regulates Tubulin Acetylation
Bernard M. H. Law et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
The Clathrin-Dependent Localization of Dopamine Transporter to Surface Membranes Is Affected by α-Synuclein
Haya Kisos et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2014)
Identification of p.Gln858*in ATP13A2 in two EOPD patients and presentation of their clinical features
Maryam Malakouti-Nejad et al.
NEUROSCIENCE LETTERS (2014)
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
Alexandria Beilina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
The Vps35 D620N Mutation Linked to Parkinson's Disease Disrupts the Cargo Sorting Function of Retromer
Jordan Follett et al.
TRAFFIC (2014)
Parkin and PINK1: much more than mitophagy
Leslie A. Scarffe et al.
TRENDS IN NEUROSCIENCES (2014)
Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations
Vinay K. Godena et al.
NATURE COMMUNICATIONS (2014)
ATP13A2/PARK9 Deficiency Neither Cause Lysosomal Impairment Nor Alter α-Synuclein Metabolism in SH-SY5Y Cells
Eun-Jin Bae et al.
Experimental Neurobiology (2014)
NCL disease mechanisms
David N. Palmer et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)
Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease-Links to Parkinson's Disease
Laura D. Osellame et al.
CELL METABOLISM (2013)
ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons
Hideaki Matsui et al.
FEBS LETTERS (2013)
Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited -synuclein accumulation and age-dependent sensorimotor deficits
Patrick J. Schultheis et al.
HUMAN MOLECULAR GENETICS (2013)
Mutation in the SYNJ1 Gene Associated with Autosomal Recessive, Early-Onset Parkinsonism
Marialuisa Quadri et al.
HUMAN MUTATION (2013)
The Sac1 Domain of SYNJ1 Identified Mutated in a Family with Early-Onset Progressive Parkinsonism with Generalized Seizures
Catharine E. Krebs et al.
HUMAN MUTATION (2013)
Reduction of Synaptojanin 1 Accelerates Aβ Clearance and Attenuates Cognitive Deterioration in an Alzheimer Mouse Model
Li Zhu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson's Disease Risk
David A. MacLeod et al.
NEURON (2013)
Dopamine and its metabolites in cathepsin D heterozygous mice before and after MPTP administration
Donna Crabtree et al.
NEUROSCIENCE LETTERS (2013)
DNAJC6 is responsible for juvenile parkinsonism with phenotypic variability
Cigdem Koroglu et al.
PARKINSONISM & RELATED DISORDERS (2013)
LRRK2 Parkinson disease mutations enhance its microtubule association
Lauren R. Kett et al.
HUMAN MOLECULAR GENETICS (2012)
Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning
Mark W. Dodson et al.
HUMAN MOLECULAR GENETICS (2012)
Trisomy for Synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes
Jack-Christophe Cossec et al.
HUMAN MOLECULAR GENETICS (2012)
Mutation of the parkinsonism gene ATP13A2 causes neuronal ceroid-lipofuscinosis
Jose Bras et al.
HUMAN MOLECULAR GENETICS (2012)
Reduction of Synaptojanin 1 Ameliorates Synaptic and Behavioral Impairments in a Mouse Model of Alzheimer's Disease
Laura Beth J. McIntire et al.
JOURNAL OF NEUROSCIENCE (2012)
Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy
Ishrat Ahmed et al.
JOURNAL OF NEUROSCIENCE (2012)
Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, α-Synuclein Accumulation, and Neurotoxicity
Marija Usenovic et al.
JOURNAL OF NEUROSCIENCE (2012)
Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of α-Synuclein and LRRK2 in the Brain
Lauren G. Friedman et al.
JOURNAL OF NEUROSCIENCE (2012)
The link between the GBA gene and parkinsonism
Ellen Sidransky et al.
LANCET NEUROLOGY (2012)
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
Youren Tong et al.
MOLECULAR NEURODEGENERATION (2012)
A Deleterious Mutation in DNAJC6 Encoding the Neuronal-Specific Clathrin-Uncoating Co-Chaperone Auxilin, Is Associated with Juvenile Parkinsonism
Simon Edvardson et al.
PLOS ONE (2012)
Inhibitory effect of dietary lipids on chaperone-mediated autophagy
Jose Antonio Rodriguez-Navarro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration
Benjamin Dehay et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Chaperone-mediated autophagy: a unique way to enter the lysosome world
Susmita Kaushik et al.
TRENDS IN CELL BIOLOGY (2012)
A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease
Alexander Zimprich et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2011)
Parkinson's Disease: Genetics and Pathogenesis
Joshua M. Shulman et al.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 6 (2011)
Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
Joseph R. Mazzulli et al.
CELL (2011)
α-Synuclein promotes clathrin-mediated NMDA receptor endocytosis and attenuates NMDA-induced dopaminergic cell death
Furong Cheng et al.
JOURNAL OF NEUROCHEMISTRY (2011)
Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of α-Synuclein
Darius Ebrahimi-Fakhari et al.
JOURNAL OF NEUROSCIENCE (2011)
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
Harvey T. McMahon et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
Linking lipids to Alzheimer's disease: cholesterol and beyond
Gilbert Di Paolo et al.
NATURE REVIEWS NEUROSCIENCE (2011)
Altered lipid content inhibits autophagic vesicular fusion
Hiroshi Koga et al.
FASEB JOURNAL (2010)
Physiological significance of selective degradation of p62 by autophagy
Masaaki Komatsu et al.
FEBS LETTERS (2010)
α-Synuclein impairs macroautophagy: implications for Parkinson's disease
Ashley R. Winslow et al.
JOURNAL OF CELL BIOLOGY (2010)
Clinical Course of the First Asian Family with Parkinsonism Related to SNCA Triplication
Takeshi Sekine et al.
MOVEMENT DISORDERS (2010)
Eaten alive: a history of macroautophagy
Zhifen Yang et al.
NATURE CELL BIOLOGY (2010)
Genetic Animal Models of Parkinson's Disease
Ted M. Dawson et al.
NEURON (2010)
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice
Youren Tong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
alpha-Synuclein Gene Rearrangements in Dominantly Inherited Parkinsonism Frequency, Phenotype, and Mechanisms
Pablo Ibanez et al.
ARCHIVES OF NEUROLOGY (2009)
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
Javier Alegre-Abarrategui et al.
HUMAN MOLECULAR GENETICS (2009)
Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - a point of convergence in Parkinsonian neurodegeneration?
Frank Gillardon
JOURNAL OF NEUROCHEMISTRY (2009)
Rab11a and HSP90 Regulate Recycling of Extracellular α-Synuclein
Jun Liu et al.
JOURNAL OF NEUROSCIENCE (2009)
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
Wataru Satake et al.
NATURE GENETICS (2009)
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
Valerie Cullen et al.
MOLECULAR BRAIN (2009)
Glucocerebrosidase gene mutations - A risk factor for Lewy body disorders
Ignacio F. Mata et al.
ARCHIVES OF NEUROLOGY (2008)
Cathepsin D is the main lysosomal enzyme involved in the degradation of α-synuclein and generation of its carboxy-terminally truncated species
Daniel Sevlever et al.
BIOCHEMISTRY (2008)
Synaptic changes in the thalamocortical system of cathepsin D-deficient mice: A model of human congenital neuronal ceroid-lipofuscinosis
Sanna Partanen et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)
Autophagy fights disease through cellular self-digestion
Noboru Mizushima et al.
NATURE (2008)
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
Liyan Qiao et al.
Molecular Brain (2008)
alpha-Synuclein gene duplication is present in sporadic Parkinson disease
T. -B. Ahn et al.
NEUROLOGY (2008)
The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals
Meera Mani et al.
NEURON (2007)
Sorting through the cell biology of Alzheimer's disease: Intracellular pathways to pathogenesis
Scott A. Small et al.
NEURON (2006)
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
Alfredo Ramirez et al.
NATURE GENETICS (2006)
Apolipoprotein E4: A causative factor and therapeutic target in neuropathology including Alzheimer's disease
RW Mahley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Clinical heterogeneity of α-synuclein gene duplication in Parkinson's disease
K Nishioka et al.
ANNALS OF NEUROLOGY (2006)
Model-guided microarray implicates the retromer complex in Alzheimer's disease
SA Small et al.
ANNALS OF NEUROLOGY (2005)
Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications
M Farrer et al.
ANNALS OF NEUROLOGY (2004)
α-synuclein locus duplication as a cause of familial Parkinson's disease
MC Chartier-Harlin et al.
LANCET (2004)
Causal relation between α-synuclein gene duplication and familial Parkinson's disease
P Ibáñez et al.
LANCET (2004)
Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy
AM Cuervo et al.
SCIENCE (2004)
Parkinsonism among Gaucher disease carriers
O Goker-Alpan et al.
JOURNAL OF MEDICAL GENETICS (2004)
Glucocerebrosidase mutations in subjects with parkinsonism
A Lwin et al.
MOLECULAR GENETICS AND METABOLISM (2004)
Abnormal α-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease
E Dalfó et al.
NEUROBIOLOGY OF DISEASE (2004)
α-Synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication
DW Miller et al.
NEUROLOGY (2004)
α-synuclein locus triplication causes Parkinson's disease
AB Singleton et al.
SCIENCE (2003)
α-synuclein is degraded by both autophagy and the proteasome
JL Webb et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
p62 is a common component of cytoplasmic inclusions in protein aggregation diseases
K Zatloukal et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
Induction of neuronal cell death by Rab5A-dependent endocytosis of α-synuclein
JY Sung et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Share Paper
