Journal
MOVEMENT DISORDERS
Volume 31, Issue 11, Pages 1748-1751Publisher
WILEY
DOI: 10.1002/mds.26759
Keywords
deep brain stimulation; basal ganglia; local field potentials; beta oscillations; subthalamic nucleus
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Funding
- German Research Foundation (DFG) [KFO 247]
- Medical Research Council [MC_UU_12024/1] Funding Source: researchfish
- Rosetrees Trust [M235-CD3] Funding Source: researchfish
- MRC [MC_UU_12024/1] Funding Source: UKRI
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ObjectiveBeta band oscillations in the subthalamic nucleus (STN) have been proposed as a pathophysiological signature in patients with Parkinson's disease (PD). The aim of this study was to investigate the potential association between oscillatory activity in the STN and symptom severity in PD. MethodsSubthalamic local field potentials were recorded from 63 PD patients in a dopaminergic OFF state. Power-spectra were analyzed for the frequency range from 5 to 95 Hz and correlated with individual UPDRS-III motor scores in the OFF state. ResultsA correlation between total UPDRS-III scores and 8 to 35 Hz activity was revealed across all patients (=0.44, P<.0001). When correlating each frequency bin, a narrow range from 10 to 15 Hz remained significant for the correlation (false discovery rate corrected P<.05). ConclusionOur results show a correlation between local STN 8 to 35 Hz power and impairment in PD, further supporting the role of subthalamic oscillatory activity as a potential biomarker for PD.
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