Clinical application of blood purification in polymyositis/dermatomyositis

Introduction: We investigated the clinical efficacy and safety of blood purification technology in patients with polymyositis/dermatomyositis.Methods: In a study of 22 patients, 10 cases received blood purification treatment (5 cases received plasma exchange, 5 cases received plasma HA280 immunoadsorption), and 12 cases served as the control group. A 3-month follow-up was conducted to compare the clinical manifestations and laboratory examination.Results:Symptoms and signs of patients in treatment group were significantly improved, and the hormone usage was lower than the control group. For patients with normal creatine kinase level and ferritin level below three times the upper limit of normal, there was a positive correlation between their N/L values and MDAAT scores.Conclusion:The results of this study suggest that blood purification therapy, including plasma HA280 immunoadsorption and plasma exchange, is an effective and safe treatment for patients with polymyositis/dermatomyositis, offering assistance in reducing hormone usage in the long-term.

Automated summary

This study investigated the clinical efficacy and safety of blood purification technology in patients with polymyositis/dermatomyositis. The results showed that blood purification treatment significantly improved symptoms and signs of patients, and reduced hormone usage.