Glasgow prognostic score as an outcome predictor for patients initiating hemodialysis

Introduction: This retrospective study examined the relationship between the Glasgow Prognostic Score (GPS) at hemodialysis (HD) initiation and overall/ cardiovascular mortality. Methods: A total of 264 patients starting HD between 2014 and 2015 at a single center were studied. Follow-up persisted until therapy change, death, or study end (December 31, 2021), with a median of 6.8 years. Results: Patients with a higher GPS more frequently had emergent HD initiation and showed increased eGFR at initiation. During follow-up, 60% of patients died, with cardiovascular disease being the leading cause. Univariate analysis revealed a significant difference in median survival time across GPS classes. Cox proportional hazard models confirmed a significant association between GPS and mortality. Conclusions: We report a significant association between GPS at HD initiation and mortality. GPS may prove useful as a prognostic tool for identifying high-risk patients, underscoring the need for future research to validate these findings and explore the potential of GPS-based interventions.

Automated summary

This retrospective study found a significant association between the Glasgow Prognostic Score (GPS) at hemodialysis (HD) initiation and overall/cardiovascular mortality. The study included 264 patients starting HD between 2014 and 2015 at a single center, with a median follow-up of 6.8 years. Patients with a higher GPS were more likely to have emergent HD initiation and higher eGFR at initiation. The findings highlight the potential of GPS as a prognostic tool for identifying high-risk patients in HD.