Copper-catalyzed one-pot synthesis of 1,4-benzothiazine-3-ones

An efficient potassium carbonate and copper-mediated C-S and C-N Ullmann coupling reaction between 2-bromothiophenol and 2-haloacetanilide is reported here. This protocol affords a simple and efficient approach for the construction of 1,4-benzothiazinone-3-one derivatives, avoiding the limitations of using noble metals and expensive ligands for the first time.

Automated summary

An efficient method for the synthesis of 1,4-benzothiazinone-3-one derivatives via a potassium carbonate and copper-mediated C-S and C-N Ullmann coupling reaction between 2-bromothiophenol and 2-haloacetanilide is reported. This approach eliminates the need for noble metals and expensive ligands, making it a simple and cost-effective strategy.