1,6-Addition of indolizines to para-quinone methides with indium(III) chloride as catalyst

A 1,6-addition of indolizines to para-quinone methides was developed using only 2 mol% indium chloride as a catalyst. The method successfully allows the regioselective addition of indolizines at positions 1 and/ or 3 to p-quinone methides, leading to the formation of the desired products in excellent yields in most cases (up to 99%) under mild conitions and in short reaction time. & COPY; 2023 Elsevier Ltd. All rights reserved.

Automated summary

A 1,6-addition reaction of indolizines to para-quinone methides with only 2 mol% indium chloride as a catalyst was developed. The method achieves regioselective addition of indolizines at positions 1 and/or 3 to p-quinone methides, leading to high yields of the desired products (up to 99%) under mild conditions and short reaction time.