Journal
TETRAHEDRON
Volume 145, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2023.133605
Keywords
Phenothiazine; Fluorescent probe; Hypochlorous acid; Live cells; Zebrafish
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In this study, a PTZ fluorescent probe based on phenothiazine was successfully synthesized for specific detection of HClO. PTZ exhibited excellent selectivity, biocompatibility, rapid response, pH stability, and low limits of detection (5.2 nM). Furthermore, PTZ could detect both exogenous and endogenous HClO rapidly in living cells and zebrafish, showing its broad potential applications in life sciences.
Hypochlorous acid (HClO) is a reactive oxygen species (ROS) that plays a critical role in numerous pathological and physiological processes. Abnormal concentrations of HClO in vivo have been closely linked to many diseases, including inflammatory disorders and cancer. In this work, an on-off fluorescent probe PTZ based on phenothiazine was synthesized for specific detection of HClO. PTZ demonstrated excellent selectivity, biocompatibility, rapid response, pH stability, and low limits of detection (5.2 nM). Furthermore, PTZ can detect both exogenous and endogenous HClO rapidly in living cells and zebrafish, which provides it with broad potential applications in life sciences.
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