Journal
TETRAHEDRON
Volume 141, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2023.133521
Keywords
Pyrazole; Triazoles; Pyrimidines; Anisole; Microwave-assisted synthesis
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A microwave-assisted method was developed for the synthesis of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines from 5-aminopyrazolyl-4-carbonitriles, orthoesters, and hydrazides in one pot. The method uses anisole as a green media and allows for diverse pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine preparation with variations in the structure of each substrate. The catalyst-free one-pot protocol, short reaction time, and convenient work-up are additional advantageous features of this method.
A one-pot microwave-assisted method for the synthesis of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimi-dines from 5-aminopyrazolyl-4-carbonitriles, orthoesters, and hydrazides was developed. The method utilizes anisole as a geen media for the reaction and tolerates variations in the structure of each substrate, thus allowing the preparation of diverse pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines. The catalyst-free one-pot protocol, short reaction time, and convenient work-up are additional beneficial features of this method.& COPY; 2023 Elsevier Ltd. All rights reserved.
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