An integrated microfluidic electrochemiluminescence device for point-of-care testing of acute myocardial infarction

Article Chemistry, Analytical

Recent progress in assembly strategies of nanomaterials-based ultrasensitive electrochemiluminescence biosensors for food safety and disease diagnosis

Lu Peng et al.

Summary: This review focuses on the representative ECL biosensors in the field of food safety and disease diagnosis based on nanomaterials assembly strategies, and summarizes them according to the different roles of nanomaterials.

TALANTA (2023)

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Article Chemistry, Analytical

Single-atom boosted electrochemiluminescence via phosphorus doping of Fe-N/P-C catalysts

Yu-Xin Yang et al.

Summary: In this study, heteroatom-doped single-atom catalysts (SACs) of Fe-N/P-C were synthesized for the catalysis of cathodic luminol electrochemiluminescence (ECL). The doping of phosphorus (P) could improve the catalytic efficiency of the oxygen reduction reaction (ORR) by lowering the reaction energy barrier. The catalysis of ORR by SACs triggered the generation of reactive oxygen species (ROS) and greatly enhanced the ECL emission. The Fe-N/P-C SACs exhibited higher catalytic activity compared to Fe-N-C SACs. The system's dependence on oxygen allowed for ultra-sensitive detection of antioxidants, such as ascorbic acid.

ANALYTICA CHIMICA ACTA (2023)

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Article Chemistry, Multidisciplinary

Electrochemiluminescence Distance and Reactivity of Coreactants Determine the Sensitivity of Bead-Based Immunoassays

Yafeng Wang et al.

Summary: In this study, the electrochemiluminescence (ECL) generation by Ru(bpy)(3)(2+) and five tertiary amine coreactants was investigated. The ECL distance and reactivity of the coreactants were measured, and the integrated ECL intensity was used to quantitatively evaluate the reactivity. Statistical analysis of ECL images of labeled microbeads showed that the ECL distance and reactivity of the coreactant determine the emission intensity and sensitivity of immunoassay. BIS-TRIS was found to balance the trade-off between ECL distance and reactivity, resulting in a 236% increase in sensitivity compared to TPrA in the bead-based immunoassay of carcinoembryonic antigen.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)

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Article Chemistry, Multidisciplinary

Design of portable electrochemiluminescence sensing systems for point-of-care-testing applications

Shuqi Xia et al.

Summary: POCT technology is highly desirable for various applications, and electrochemiluminescence (ECL) is a promising method due to its advantages. However, developing portable ECL devices that can accurately quantify on-site remains challenging. This review focuses on summarizing recent examples of portable ECL devices and analyzing their key components, discussing the challenges and potential solutions, and providing future perspectives.

CHINESE CHEMICAL LETTERS (2023)

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Article Chemistry, Analytical

Artificial neural network processed linear-light tristimulus and hue parameters of fluorescence for smartphone assisted point-of-care testing device

Huiting Chen et al.

SENSORS AND ACTUATORS B-CHEMICAL (2023)

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Article Chemistry, Analytical

Dry Chemistry-Based Bipolar Electrochemiluminescence Immunoassay Device for Point-of-Care Testing of Alzheimer-Associated Neuronal Thread Protein

Yi Liang et al.

Summary: In this study, a novel electrochemiluminescence (ECL) immunoassay device was developed for the point-of-care testing of Alzheimer-associated neuronal thread protein (AD7c-NTP). The device allows automatic collection and analysis of ECL signals after manual addition of sample and buffer solutions onto the immunosensor. The proposed device demonstrated acceptable selectivity, stability, and reproducibility, and successfully detected AD7c-NTP levels in human urine.

ANALYTICAL CHEMISTRY (2023)

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Article Chemistry, Multidisciplinary

A Skin-Interfaced, Miniaturized Microfluidic Analysis and Delivery System for Colorimetric Measurements of Nutrients in Sweat and Supply of Vitamins Through the Skin

Joohee Kim et al.

Summary: A miniaturized system is presented in this study for simple and rapid measurement of multiple essential nutrients in sweat. The system allows for passive and sustained delivery of these nutrients to the body. Results show correlations between the concentrations of nutrients in sweat and blood, highlighting the practical potential of this system for monitoring nutritional balance.

ADVANCED SCIENCE (2022)

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Article Chemistry, Analytical

Electrochemiluminescence sensor for point-of-care detection of pyrrolizidine alkaloids

Yi Xiao et al.

Summary: In this study, a visual, easy-to-use, and economic sensor was developed for confirmative measurement of PAs in routine clinical tests. The sensor exhibited excellent linearity, low detection limits, and good recoveries, indicating good accuracy and practicability. This portable and low-cost sensor holds promise to be applied to point-of-care testing of PAs in drugs, food products, and clinical samples.

TALANTA (2022)

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Article Chemistry, Multidisciplinary

Toward Next-Generation Mobile Diagnostics: Near-Field Communication-Powered Electrochemiluminescent Detection

Joseba Totoricaguena-Gorrino et al.

Summary: Mobile phones have been used in combination with point of care (PoC) devices for over a decade. However, their use seems limited to detection of sensing events using video and camera functions. In contrast, the potential of using mobile phones to power PoC devices has been largely unexplored. This work demonstrates the feasibility of using a smartphone to both power and analyze an electrochemiluminescence (ECL) detection system.

ACS SENSORS (2022)

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Article Biochemistry & Molecular Biology

A simple, low-cost instrument for electrochemiluminescence immunoassays based on a Raspberry Pi and screen-printed electrodes

Laena D'Alton et al.

Summary: This article describes a powerful, low-cost, and semi-portable electrochemiluminescence (ECL) biosensing device based on a Raspberry Pi single-board computer. The Pi serves as the controller and user interface, interfacing with an expansion board that controls the potential applied to a disposable screen-printed electrode and facilitates data acquisition from a photomultiplier tube (PMT). The Raspberry Pi-based setup demonstrates comparable analytical performance to a traditional ECL configuration and has the potential to replace conventional ECL setups at a fraction of the cost, without sacrificing sensitivity or versatility. This combination of a single-board computer and a sensitive light detector represents an important step towards mobile, point-of-care diagnostic platforms for ECL instruments.

BIOELECTROCHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Distance-Based All-In-One Immunodevice for Point-of-Care Monitoring of Cytokine Interleukin-6

Kawin Khachornsakkul et al.

Summary: We developed a distance-based paper analytical device with a hydrophilic bridge valve for quantitatively monitoring IL-6 in human samples. The device is user-friendly, does not require external instrumentation, and showed consistent results with the standard clinical laboratory method. This rapid analysis method is suitable for point-of-care diagnostics and analysis in resource-limited settings.

ACS SENSORS (2022)

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Article Chemistry, Multidisciplinary

Highly Efficient PTCA/Co3O4/CuO/S2O82- Ternary Electrochemiluminescence System Combined with a Portable Chip for Bioanalysis

Xianzhen Song et al.

Summary: In this study, an efficient ECL biosensor chip for sensitive detection of NSE was developed. The use of co-reaction promoters, affinity ligands, and unique structure nanomaterials enabled highly sensitive detection of NSE. The biosensor exhibited good performance and potential for practical applications in clinical sensing analysis.

ACS SENSORS (2022)

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Article Chemistry, Analytical

Simultaneous SERS-based immunoassay of dual cardiac markers on pump-free hybrid microfluidic chip

Rongke Gao et al.

Summary: We developed a new pump-free hybrid microfluidic chip for simultaneous detection of creatine kinase MB isoenzyme and cardiac troponin cardiac markers. The integration of paper and PDMS microfluidic chip offers portability, low-cost, and high sensitivity.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Analytical

A fully integrated and handheld electrochemiluminescence device for detection of dopamine in bio-samples

Lihang Zhu et al.

Summary: This study presents a fully integrated and handheld ECL device, consisting of a flexible printed circuit board based electrochemical module, a silicon photomultiplier, and a Bluetooth enabled smartphone. The device has a compact size, making it suitable for on-site detection and POCT. Experimental results demonstrate that the device exhibits fast response to dopamine and meets the basic requirements for POCT in complex bio-samples.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Multidisciplinary Sciences

Soft shape-programmable surfaces by fast electromagnetic actuation of liquid metal networks

Xinchen Ni et al.

Summary: The authors introduce a shape-reprogrammable construct based on liquid metal microfluidic networks and electromagnetic actuation. This construct is capable of fast, continuous morphing into different three-dimensional configurations with reversible operation.

NATURE COMMUNICATIONS (2022)

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Article Chemistry, Multidisciplinary

Spatial Regulation Control of Oxygen Metabolic Consumption in Mouse Brain

Lin Zhou et al.

Summary: This study combines in vivo electrochemistry with physiological and ethological analyses to explore oxygen metabolic consumption in a region of the mouse brain, revealing the spatial regulation control of oxygen consumption and the potential risks of neuronal damage from long-term intake of high-dose caffeine.

ADVANCED SCIENCE (2022)

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Article Chemistry, Analytical

Charge-Dependent Signal Changes for Label-Free Electrochemiluminescence Immunoassays

Dexin Du et al.

Summary: Label-free electrochemiluminescence (ECL) immunoassays (lf-ECLIA) have become an attractive method for biomarker detection due to their simplicity, speed, and cost-effectiveness. This study investigated the interaction between biomarkers and analytical interfaces constructed using a nanoluminophore and antibody-functionalized gold nanoparticles. The results showed that positively charged biomarkers increased the ECL intensity, while negatively charged biomarkers decreased the ECL intensity. A charge-dependent lf-ECLIA method was established based on the ECL signal changes, which exhibited different responses to positively charged and negatively charged biomarkers.

ANALYTICAL CHEMISTRY (2022)

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Article Biophysics

A highly sensitive electrochemiluminescence immunosensor for h-FABP determination based on self-enhanced luminophore coupled with ultrathin 2D nickel metal-organic framework nanosheets

Xiufeng Gan et al.

Summary: A novel ECL immunosensor based on self-enhanced luminophore and ultrathin 2D nickel MOF nanosheets was developed for sensitive and specific detection of h-FABP. The immunosensor exhibited a wide dynamic range and low detection limit, demonstrating excellent specificity and successful application in complex physiological matrices for target protein detection. This work may provide an alternative method for biomarker detection in clinical diagnosis and expand the application potential of 2D MOF nanosheets in ECL technique.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Chemistry, Multidisciplinary

Gold Nano/Micro-Islands Overcome the Molecularly Imprinted Polymer Limitations to Achieve Ultrasensitive Protein Detection

Alireza Sanati et al.

Summary: The electrochemical biosensor based on the core-shell structure of gold NMIs and MIP shows high sensitivity, stability, lower detection time and limit in clinical applications compared to traditional methods like ELISA and lateral flow assay rapid test kits.

ACS SENSORS (2021)

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Article Chemistry, Multidisciplinary

Ratiometric Fluorescent Lateral Flow Immunoassay for Point-of-Care Testing of Acute Myocardial Infarction

Jing Wang et al.

Summary: A highly sensitive ratiometric fluorescent lateral flow immunoassay strip was developed for the rapid and accurate detection of the acute myocardial infarction biomarker, H-FABP. By utilizing a custom smartphone-based analytical device and tonality analysis, quantitative detection of H-FABP with a low limit of detection was achieved. The visually distinguishable color change on the strip around the threshold concentration of H-FABP enables semi-quantitative diagnosis by the naked eye.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Chemistry, Multidisciplinary

Rational Design of Electrochemiluminescent Devices

Xiangui Ma et al.

Summary: Electrochemiluminescence (ECL) combines electrochemical and chemiluminescent methods, used in clinical analysis and biological research. Efforts focus on enhancing sensitivity, portability, and affordability of ECL devices. The research aims to develop new electrodes, wireless power transfer (WPT) based devices, and novel bipolar electrochemistry.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

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Article Biophysics

Real time detection of 3-nitrotyrosine using smartphone-based electrochemiluminescence

Lihang Zhu et al.

Summary: The article introduces a handheld electrochemiluminescence analysis device for early diagnosis of cardiovascular diseases, which can rapidly and accurately detect 3-nitrotyrosine. The device combines printed circuit board and smartphone technologies, with extensive prospects for application.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Chemistry, Analytical

Electrochemiluminescence resonance energy transfer system fabricated by quantum state complexes for cardiac troponin I detection

Zhanglei Wu et al.

Summary: This study proposed a novel ECL-based biosensor using gold nanoclusters coupled with graphene quantum dots as signal labels, supported on well-ordered Co3O4 nanoarrays as the sensing substrate. The biosensor showed good ECL response for detecting cardiac troponin I, with a satisfactory linear range and ultra-low detection limit. The rational design of this biosensor provides a clue for enhancing the ECL-RET model.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Multidisciplinary

Molecularly Imprinted Polymer/Anodic Aluminum Oxide Nanocomposite Sensing Electrode for Low-Concentration Troponin T Detection for Patient Monitoring Applications

Yu-Tsan Lin et al.

Summary: A novel sensing electrode, the anodic aluminum oxide molecularly imprinted (MIP/AAO) nanocomposite electrode, has been developed with improved performance for detecting cTnT in patients' blood serum. By incorporating the AAO structure and semiconductor-compatible process, the new electrode shows higher sensitivity, lower limit of detection, and linear characteristic in the measurement range of low-concentration cTnT, effectively improving accuracy and reducing errors in measurement.

ACS SENSORS (2021)

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Article Nanoscience & Nanotechnology