Total Synthesis of Marine Macrolide Natural Products by the Macrocyclization/Transannular Pyran Cyclization Strategy

In this Account, we summarize the development of a new strategy for streamlined synthesis of tetrahydropyran-embedded macrolactones and its successful implementation to a 13-step synthesis of (-)-exiguolide and an 11-step synthesis of (+)-neopeltolide.1 Introduction2 Development of Macrocyclization/Transannular Pyran Cyclization Strategy3 Total Synthesis of (-)-Exiguolide4 Total Synthesis of (+)-Neopeltolide5 Conclusions

Automated summary

In this paper, the development of a new strategy for streamlined synthesis of tetrahydropyran-embedded macrolactones is summarized, as well as its successful implementation in the total synthesis of two natural products. The method enables a reduction in steps and an improvement in synthesis efficiency.