Asymmetric Allenylation of N -Acylhydrazones with Propargyltrichlorosilane Catalyzed by Helical Chiral 2,2'& nbsp;-Bipyridine N -Monoxide

(M)-Helicene-derived 2,2'-bipyridine N-monoxide catalyzed the allenylation of N-acylhydrazones with propargyltrichlorosilane with excellent regioselectivity and moderate-to-good enantioselectivity. This study represents the first catalytic asymmetric allenylation of acylhydrazones.

Automated summary

This study presents the first catalytic asymmetric allenylation of acylhydrazones using (M)-helicene-derived 2,2'-bipyridine N-monoxide as a catalyst, which exhibits excellent regioselectivity and moderate-to-good enantioselectivity.