Steroid-triazole conjugates: A brief overview of synthesis and their application as anticancer agents

Steroids are biomolecules that play pivotal roles in various physiological and drug discovery processes. Abundant research has been fuelled towards steroid-heterocycles conjugates over the last few decades as potential thera-peutic agents against various diseases especially as anticancer agents. In this context various steroid-triazole conjugates have been synthesized and studied for their anticancer potential against various cancer cell lines. A thorough search of the literatures revealed that a concise review pertaining the present topic is not compiled. Therefore, in thus review we summarize the synthesis, anticancer activity against various cancer cell lines and structure activity relationship (SAR) of various steroid-triazole conjugates. This review can lay down the path towards the development of various steroid-heterocycles conjugates with lesser side effects and profound efficacy.

Automated summary

Steroids are biomolecules that play important roles in physiology and drug discovery. Research on steroid-heterocycle conjugates as potential therapeutic agents, especially anticancer agents, has increased over the past few decades. This review summarizes the synthesis, anticancer activity, and structure-activity relationship (SAR) of various steroid-triazole conjugates against different cancer cell lines. It provides a foundation for the development of steroid-heterocycle conjugates with reduced side effects and improved efficacy.