Click derived organosilane assembled with nano platform for the detection of Cu2+ions: Biological evaluation and molecular docking approach

Metal ions have active roles in biochemical, industrial, and environmental processes. The design and develop-ment of new rapid sensing materials with advanced reasonable, compelling, and convenient, techniques are urgent. Here in this work, we design and develop sensor with the facile amalgamation of the pyrene-based organosilane (5) through a click silylation approach silicon composite for selective detection of Cu2+ ions. Physicochemical and keen methods are employed to perceive the resultant hybrid nanoparticles (H-NPs), and these nanocomposites similarly displayed a strong affection for Cu2+ ions. In addition, the identification re-strictions while utilizing 5 and H-NP's towards Cu2+ found in this study are far lower than the WHO rules for drinking water. Further, organosilane (5) shows good antibacterial and antioxidant activity. The antibacterial effects of triazole-based organosilane (5), are evaluated with a molecular docking study with Escherichia coli (IJZQ) was conducted. The selected ligand was revealed to have a reasonable docking score with a binding energy of-8.40 kcal mol-1.

Automated summary

Metal ions play important roles in biochemical, industrial, and environmental processes, and there is an urgent need to design and develop new rapid sensing materials with advanced techniques. In this study, a sensor was designed and developed using a facile amalgamation of a pyrene-based organosilane (5) through a click silylation approach to selectively detect Cu2+ ions. Physicochemical and keen methods were employed to characterize the resulting hybrid nanoparticles (H-NPs), which showed strong affinity for Cu2+ ions. Moreover, the identification restrictions of 5 and H-NP towards Cu2+ ions were found to be much lower than the WHO guidelines for drinking water. Additionally, organosilane (5) exhibited good antibacterial and antioxidant activity as evaluated through a molecular docking study with Escherichia coli (IJZQ), showing reasonable docking score and binding energy of -8.40 kcal mol-1.