4.8 Article

Effects of Skeleton Structure of Mesoporous Silica Nanoadjuvants on Cancer Immunotherapy

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

ZIF-8 Nanoparticles Evoke Pyroptosis for High-Efficiency Cancer Immunotherapy

Binbin Ding et al.

Summary: Researchers discovered that ZIF-8 nanoparticles can induce pyroptosis, a form of cell death, through a caspase-1/gasdermin D (GSDMD)-dependent pathway. This cell death process is accompanied by necrosis and immunogenic cell death (ICD), which triggers an immune response. Furthermore, loading a mitochondrial depolarizing agent, CCCP, into ZIF-8 nanoparticles enhances the pyroptosis process. The modified F127-ZIF-8(CCCP) nanoparticles activate anti-tumor immune response and reshape the tumor microenvironment, leading to effective tumor growth inhibition. This study advances the biomedical applications of ZIF-8 and offers insights into pyroptosis-induced cancer therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)

Review Chemistry, Multidisciplinary

Understanding Structure-Function Relationships of Nanoadjuvants for Enhanced Cancer Vaccine Efficacy

Jia Tan et al.

Summary: This article reviews nanoadjuvants and their structure-function relationships, as well as their applications in cancer therapy. The article first introduces different types of adjuvants and then discusses their mechanisms. It summarizes the methods for evaluating immune effects of adjuvants. The authors particularly focus on the structure-function relationships of nanoadjuvants and explore their impact on immune activities. Finally, the safety of adjuvants is discussed, and representative advancements of nanoadjuvants in tumor immunotherapy and other therapies are presented.

ADVANCED FUNCTIONAL MATERIALS (2022)

Review Chemistry, Inorganic & Nuclear

Chemically engineered mesoporous silica nanoparticles-based intelligent delivery systems for theranostic applications in multiple cancerous/non-cancerous diseases

Shuai Zhou et al.

Summary: Recent advances in biomedical nanotechnology have led to the development of drug delivery systems based on mesoporous silica nanoparticles, which have the potential as multifunctional delivery platforms for treating various diseases.

COORDINATION CHEMISTRY REVIEWS (2022)

Article Engineering, Biomedical

Mn2+/Fe3+/Co2+ and Tetrasulfide Bond Co-Incorporated Dendritic Mesoporous Organosilica as Multifunctional Nanocarriers: One-Step Synthesis and Applications for Cancer Therapy

Bin Liu et al.

Summary: In this study, researchers successfully incorporated manganese ions, iron ions, or cobalt ions and tetrasulfide bonds into the framework of DMOS, resulting in multifunctional nanoparticles. These nanoparticles can be used as carriers for anti-cancer drugs and enhance the efficiency of photodynamic therapy through multiple mechanisms.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Chemistry, Multidisciplinary

Nanostructured Organosilica Nitric Oxide Donors Intrinsically Regulate Macrophage Polarization with Antitumor Effect

Shevanuja Theivendran et al.

Summary: This study reports the synthesis of a nanoparticle-based NO delivery platform that utilizes tetrasulfide-modified organosilica nanoparticles for effective NO delivery and macrophage activation. The enhanced intracellular delivery of NO resulted in macrophage activation and delayed tumor growth in a breast cancer model.

ACS NANO (2022)

Article Multidisciplinary Sciences

Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell response

Jinjin Chen et al.

Summary: This study explores an endogenously LN-targeting lipid nanoparticle (LNP) for developing mRNA cancer vaccines, showing improved targeting efficiency and enhanced antitumor efficacy.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Pharmacology & Pharmacy

Dual-responsive nanovaccine for cytosolic delivery of antigens to boost cellular immune responses and cancer immunotherapy

Yang Sui et al.

Summary: Cancer vaccines are a promising strategy for tumor immunotherapy, but targeting the cytosols of dendritic cells in the lymph nodes remains a challenge. This study developed a novel delivery system and formulation to effectively deliver antigens to the lymph nodes, enhancing antigen cross-presentation efficiency. The combination of the tumor vaccine with anti-PD-1 showed excellent therapeutic effects in treating ectopic melanoma and lung metastasis melanoma.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

Review Medicine, Research & Experimental

New insights from the single-cell level: Tumor associated macrophages heterogeneity and personalized therapy

Xiaomin Wang et al.

Summary: Tumor-associated macrophages (TAMs) play a crucial role in tumor microenvironment and their invasion in tumors is closely related to poor prognosis. However, studying TAMs' heterogeneity and developing drugs targeting them is challenging. Single-cell RNA sequencing (scRNA-seq) provides an efficient detection method to reveal TAMs' heterogeneity and offers more accurate information for TAM-related studies.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Review Immunology

Redox regulation of the immune response

Gerwyn Morris et al.

Summary: The immune-inflammatory response is associated with increased nitro-oxidative stress. Redox-associated mechanisms play a crucial role in modulating various aspects of the immune response. Chronic nitro-oxidative stress can have detrimental effects on immune cells and their functions.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

Article Engineering, Biomedical

Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Boyi Niu et al.

Summary: Glutathione (GSH) plays a crucial role in cellular antioxidative system, particularly in cancer cells, where a high level of GSH is essential for scavenging ROS and detoxifying xenobiotics. Depletion of GSH has been shown to enhance the efficacy of various therapies such as ROS-based therapy, ferroptosis, and chemotherapy. This review comprehensively discusses the importance of GSH depletion in cancer therapy and various strategies employed to achieve it.

BIOMATERIALS (2021)

Article Nanoscience & Nanotechnology

Core Hydrophobicity of Supramolecular Nanoparticles Induces NLRP3 Inflammasome Activation

Dipika Nandi et al.

Summary: Designer nanomaterials capable of delivering immunomodulators to specific immune cells have been extensively studied, but certain nanomaterials can nonspecifically activate NLRP3 inflammasomes, leading to unwanted effects. Core hydrophobicity strongly activates NLRP3 assembly compared to other nanoparticle attributes. Different signaling pathways and kinetics are observed with varying core hydrophobicity patterns.

ACS APPLIED MATERIALS & INTERFACES (2021)

Review Chemistry, Multidisciplinary

Nanotechnology for Boosting Cancer Immunotherapy and Remodeling Tumor Microenvironment: The Horizons in Cancer Treatment

Shan Gao et al.

Summary: Immunotherapy utilizing the human immune system against cancer has become a mainstream strategy, with the potential to eliminate tumors and treat metastasis and recurrence. The development of nanotechnology has enabled the application of nanomaterials in cancer immunotherapy, offering significant potential for improving treatment efficacy. Nanotechnology-based immunotherapy aims to produce effective anti-tumor immune responses and enhance tumor immune defense by modulating the immune suppression mechanism in the tumor microenvironment.

ACS NANO (2021)

Article Chemistry, Multidisciplinary

Engineering a self-navigated MnARK nanovaccine for inducing potent protective immunity against novel coronavirus

Yaling Wang et al.

Summary: The new nanovaccine containing RBD and MnARK shows stronger neutralizing abilities against infection compared to the Alum-adsorbed RBD vaccine. The co-delivery of RBD antigen and MnARK to lymph nodes promotes cellular internalization and the activation of immune cells.

NANO TODAY (2021)

Article Chemistry, Multidisciplinary

Disulfide-Containing Molecular Sticker Assists Cellular Delivery of DNA Nanoassemblies by Bypassing Endocytosis

Wen Yang et al.

Summary: This study developed a disulfide-containing molecular sticker (DSMS) assisted approach to achieve efficient cytosolic delivery of DNA nanoassemblies. The results showed that the DSMS-DNA nanoassemblies complex entered cells through thiol-mediated direct uptake, providing a potential agent for various applications in bioimaging, drug delivery, and gene therapy.

CCS CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Targeting tumor-associated macrophages to synergize tumor immunotherapy

Xiaonan Xiang et al.

Summary: Tumor-associated macrophages (TAMs) play a significant role in tumor immunotherapies, with potential therapeutic value in enhancing treatment outcomes.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Chemistry, Multidisciplinary

MnOxNanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect

Binbin Ding et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Multidisciplinary Sciences

The pore size of mesoporous silica nanoparticles regulates their antigen delivery efficiency

Xiaoyu Hong et al.

SCIENCE ADVANCES (2020)

Review Biotechnology & Applied Microbiology

Applications of Immunomodulatory Immune Synergies to Adjuvant Discovery and Vaccine Development

Janine K. Tom et al.

TRENDS IN BIOTECHNOLOGY (2019)

Article Biotechnology & Applied Microbiology

Precision-porous templated scaffolds of varying pore size drive dendritic cell activation

Ruying Chen et al.

BIOTECHNOLOGY AND BIOENGINEERING (2018)

Article Materials Science, Biomaterials

Peptide Amphiphile Micelle Vaccine Size and Charge Influence the Host Antibody Response

Rui Zhang et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

Article Materials Science, Biomaterials

Peptide Amphiphile Micelle Vaccine Size and Charge Influence the Host Antibody Response

Rui Zhang et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

Review Chemistry, Multidisciplinary

Bypassing Endocytosis: Direct Cytosolic Delivery of Proteins

Shubo Du et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Article Nanoscience & Nanotechnology

The Effect of Superparamagnetic Iron Oxide Nanoparticle Surface Charge on Antigen Cross-Presentation

Yongbin Mou et al.

NANOSCALE RESEARCH LETTERS (2017)

Article Nanoscience & Nanotechnology

The Effect of Superparamagnetic Iron Oxide Nanoparticle Surface Charge on Antigen Cross-Presentation

Yongbin Mou et al.

NANOSCALE RESEARCH LETTERS (2017)

Article Chemistry, Multidisciplinary

Facile Synthesis of Uniform Virus-like Mesoporous Silica Nanoparticles for Enhanced Cellular Internalization

Wenxing Wang et al.

ACS CENTRAL SCIENCE (2017)

Article Chemistry, Multidisciplinary

Strain-Promoted Thiol-Mediated Cellular Uptake of Giant Substrates: Liposomes and Polymersomes

Nicolas Chuard et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Chemistry, Multidisciplinary

Accumulating nanoparticles by EPR: A route of no return

Romeo Ngoune et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Article Engineering, Biomedical

Comprehensive Mechanism Analysis of Mesoporous-Silica-Nanoparticle-Induced Cancer Immunotherapy

Xiupeng Wang et al.

ADVANCED HEALTHCARE MATERIALS (2016)

Review Biochemistry & Molecular Biology

Human dendritic cell subsets and function in health and disease

Meredith O'Keeffe et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2015)

Article Engineering, Biomedical

Pore size-dependent immunogenic activity of mesoporous silica-based adjuvants in cancer immunotherapy

Xiupeng Wang et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2014)

Review Pharmacology & Pharmacy

Targeting Antigens to Dendritic Cell Receptors for Vaccine Development

Vasso Apostolopoulos et al.

JOURNAL OF DRUG DELIVERY (2013)

Article Chemistry, Multidisciplinary

Engineering Nano- and Microparticles to Tune Immunity

James J. Moon et al.

ADVANCED MATERIALS (2012)

Review Biotechnology & Applied Microbiology

Exploiting cell surface thiols to enhance cellular uptake

Adrian G. Torres et al.

TRENDS IN BIOTECHNOLOGY (2012)

Review Immunology

Vaccine Adjuvants: Putting Innate Immunity to Work

Robert L. Coffman et al.

IMMUNITY (2010)